Research Resource for a National Swine Resource and Research Center (U42 Clinical Trial Not Allowed)
Can you apply?
This grant is for research institutions seeking cooperative agreement funding to operate a National Swine Resource and Research Center. Applicants must have capacity to create, breed, and distribute genetically modified swine models for biomedical research. The center must provide genotyping, phenotyping, infectious disease monitoring, and training services to the national research community.
Eligible applicants typically include academic institutions, research centers, and organizations with established animal husbandry infrastructure. Organizations must demonstrate expertise in swine genetics, breeding protocols, and biomedical model development. Applicants should show commitment to reducing redundancy and costs for the broader research community.
Geographic scope is national. This is a cooperative agreement requiring ongoing operational capacity and institutional commitment. The center will serve researchers across the United States.
Key dates
- May 6, 2026 Applications open
- Jan 25, 2027 Application deadline in 238 days
- Dec 1, 2027 Award announced
- Dec 14, 2027 Project start
This grant is for research institutions seeking cooperative agreement funding to operate a National Swine Resource and Research Center. Applicants must have capacity to create, breed, and distribute genetically modified swine models for biomedical research. The center must provide genotyping, phenotyping, infectious disease monitoring, and training services to the national research community.
Eligible applicants typically include academic institutions, research centers, and organizations with established animal husbandry infrastructure. Organizations must demonstrate expertise in swine genetics, breeding protocols, and biomedical model development. Applicants should show commitment to reducing redundancy and costs for the broader research community.
Geographic scope is national. This is a cooperative agreement requiring ongoing operational capacity and institutional commitment. The center will serve researchers across the United States.
Program description
This Notice of Funding Opportunity (NOFO) encourages applications to provide continuing support for a National Swine Resource and Research Center (NSRRC). The NSRRC aims to enable gold-standard science in biomedical research by serving as a centralized national resource for the creation, breeding, cryopreservation, and distribution of genetically modified models. By consolidating these essential functions, the NSRRC significantly reduces variability and improves reproducibility across studies, ensuring that researchers have access to consistent, high-quality, specific pathogen-free models. Centralizing the resource also eliminates redundancy and high costs associated with individual laboratories maintaining separate facilities and breeding programs for these models, allowing investigators to focus their efforts on research rather than infrastructure. Additionally, the NSRRC provides genotyping and phenotyping services, infectious disease monitoring, and protocol distribution to facilitate their use for biomedical research. The Center also serves as a source of information and training related to the care and use of these models in biomedical research to study human health and disease and suitability of a model’s faithful representation of the biological system(s) proposed to be studied. The Center serves as a resource to lead the development of alternative or complementary approaches available, including new approach methodologies (NAMs), alongside in vivo models.
Who can apply
Eligible applicants
- 501(c)(3) Public Charity
- City / Municipal Government
- County Government
- Nonprofits
- Private University
- Public Authority
- Public K-12 School
- Public University
- Small Business (SBA-defined)
- Special District
- State Government
- Tribal Nation
- Tribal Organization
Details
This grant is for research institutions seeking cooperative agreement funding to operate a National Swine Resource and Research Center. Applicants must have capacity to create, breed, and distribute genetically modified swine models for biomedical research. The center must provide genotyping, phenotyping, infectious disease monitoring, and training services to the national research community.
Eligible applicants typically include academic institutions, research centers, and organizations with established animal husbandry infrastructure. Organizations must demonstrate expertise in swine genetics, breeding protocols, and biomedical model development. Applicants should show commitment to reducing redundancy and costs for the broader research community.
Geographic scope is national. This is a cooperative agreement requiring ongoing operational capacity and institutional commitment. The center will serve researchers across the United States.
How to apply
Application links
Key dates & requirements
Required documents
- SF-424 (Application for Federal Assistance)
- SF-424 Supplement (R&R)
- Project Narrative
- Budget and Budget Justification
- Biosafety and Animal Care Documentation (IACUC approval)
- Letters of Support from Research Community
Program contact
- 👤 Office of Research Infrastructure Programs (ORIP)
- 📧 ORIPDCM@mail.nih.gov
- 📞 301-435-0744
Funding track record
Recent awards under CFDA 93.351 from the last 3 years — real organizations that won funding through this same program.
Top 10 Largest Recent Awards
-
$189,307,929
-
$188,853,963
-
$179,413,083
-
$156,271,917
-
$140,230,629
-
$132,964,607
-
$122,234,337
-
$37,946,246
-
$37,475,785
-
$33,218,050
Top States by Funding
- OR 7 awards $270.5M
- CA 8 awards $254.8M
- TX 10 awards $224.3M
- WA 2 awards $219.0M
- LA 5 awards $184.0M
Source: USAspending.gov — federal spending transparency. Data covers last 3 years.
Funding history
Annual funding for this program — Federal obligations (CFDA 93.351). How funding has trended year over year.
| 2024 | $279,889,905 | |
| 2025 | $284,089,258 | |
| 2026 est. | $283,084,958 |
FAQ
Who can apply for this grant?
Research institutions with established swine breeding and genetics infrastructure. Organizations must demonstrate capacity to serve as a national resource and provide services to external researchers.
What is the funding structure?
This is a cooperative agreement with a fixed annual award of approximately $960,898-$1,008,943. No cost-sharing is required.
What activities are supported?
Creating and breeding genetically modified swine models, cryopreservation, distribution services, genotyping and phenotyping, infectious disease monitoring, and researcher training.
When is the deadline?
January 25, 2027. This is a fixed deadline with no rolling intake.
Is this highly competitive?
Yes. This supports a single national center with specialized infrastructure requirements. Strong track record in swine genetics and existing facilities are essential.
💡 Tips for applicants
- Demonstrate existing swine breeding infrastructure and genetics expertise. Document your current breeding programs and facilities.
- Show how your center reduces costs and redundancy for the national research community. Provide data on current researcher demand.
- Detail genotyping, phenotyping, and infectious disease monitoring capabilities. Include protocols and quality assurance procedures.
- Address how you will develop new approach methodologies (NAMs) alongside traditional in vivo models. Show commitment to advancing the field.
- Include letters of support from current and prospective researcher users. Evidence of demand strengthens competitiveness.
⚠️ Common mistakes
Underestimating the operational costs of maintaining a national resource. Lack of documented evidence of current researcher demand and utilization projections. Insufficient detail on quality control, genetic characterization, and disease monitoring procedures.
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