Resource-Related Research Projects (R24 Clinical Trial Not Allowed)
Can you apply?
This grant is for researchers seeking funding to develop, enhance, or maintain valuable research resources and platforms. Eligible applicants include university faculty, research institutions, nonprofit organizations, and federally funded research centers. The scope is national. Activities supported include creating biomedical research tools, databases, reagent production, animal models, and shared research infrastructure. Clinical trials are explicitly not eligible. Applicants must demonstrate how their resource will advance research in infectious diseases or immunology.
Program description
This notice of funding opportunity (NOFO) invites applications for investigator-initiated Resource-Related Research Projects (R24). The proposed resource must provide a significant benefit to currently funded high priority projects in need of further coordination and support in the areas specified. This mechanism may also be used to support development of a new resource to the broader scientific community of the National Institute of Allergy and Infectious Diseases (NIAID). It is anticipated that the request for resource support through the R24 activity code will occur on an infrequent basis and only in circumstances where other mechanisms of support from the NIAID are not appropriate.The proposed resources should be relevant to the scientific areas of the NIAID mission including the biology, pathogenesis, and host response to microbes, including HIV; the mechanisms of normal immune function and immune dysfunction resulting in autoimmunity, immunodeficiency, allergy, asthma, and transplant rejection; and translational research to develop vaccines, therapeutics, and diagnostics to prevent and treat infectious, immune-mediated, and allergic diseases.
Who can apply
Eligible applicants
How to apply
Application links
Key dates & requirements
Required documents
- SF-424 R&R Cover Page
- Project Narrative (specific aims, significance, innovation, approach, resource management)
- Budget and Budget Narrative
- Biographical Sketch (NIH format)
- Other Support documentation
- Letters of Support from potential users
- Data Sharing Plan
- Resource Management Plan
Program contact
- 👤 National Institutes of Health
- 📧 NIAID_R24_NOFO@mail.nih.gov
- 📞 301-402-2541
Funding track record
Recent awards under CFDA 93.855 from the last 3 years — real organizations that won funding through this same program.
Top 10 Largest Recent Awards
-
$438,527,853
-
$246,626,852
-
$204,359,786
-
$201,437,825
-
$200,221,259
-
$185,816,804
-
$180,737,624
-
$136,265,880
-
$116,817,868
-
$99,478,296
Top States by Funding
- CA 10 awards $818.8M
- WA 3 awards $684.0M
- MA 6 awards $602.8M
- NC 3 awards $446.4M
- NY 7 awards $375.8M
Source: USAspending.gov — federal spending transparency. Data covers last 3 years.
Funding history
Annual funding for this program — Federal obligations (CFDA 93.855). How funding has trended year over year.
| 2024 | $4,073,812,529 | |
| 2025 | $4,378,235,639 | |
| 2026 est. | $4,299,426,996 |
FAQ
Who is eligible to apply?
Faculty at academic institutions, nonprofit organizations, and FFRCs can apply. Foreign organizations and for-profit companies typically are not eligible.
Can I include clinical trial activities?
No. This R24 mechanism explicitly does not support clinical trials. Focus on resource development and maintenance only.
What types of resources are fundable?
Databases, biobanks, animal models, specialized equipment, reagent production, and shared research platforms are typical examples.
How competitive is this grant?
Very competitive. Only strong preliminary data and clear demonstration of broad research utility increase chances.
What is the typical funding range?
R24 grants typically range from $200,000 to $500,000 annually, but specific amounts vary by program.
💡 Tips for applicants
- Clearly demonstrate that your resource will serve a broad research community, not just your lab.
- Show strong preliminary data proving your resource works and will be sustainable beyond the grant period.
- Address data sharing, access policies, and user support mechanisms explicitly in your plan.
- Include letters of support from researchers who will actually use your resource.
- Explain long-term sustainability and how you will maintain the resource after NIH funding ends.
⚠️ Common mistakes
Proposing a resource with narrow use or unclear impact on infectious disease research. Failing to demonstrate adequate preliminary data or feasibility. Weak sustainability plan with no funding strategy post-grant.
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