Resource-Related Research Projects for Development of Models and Related Materials for Studying Human Health and Diseases (R24 Clinical Trials Not Allowed)
🏛 National Institutes of Health (HHS-NIH11)
✓ Free, no account · Source: Grants.gov · Last verified Jul 16, 2026
Can you apply?
This grant is for researchers and research institutions seeking support for resource-related research projects that develop models and materials for studying human health and diseases. NIH R24 grants typically support established research infrastructure, platforms, and resources that benefit the broader scientific community rather than single-investigator projects.
Eligible applicants include universities, research institutions, medical schools, teaching hospitals, and other organizations with research capacity. Domestic and international organizations may apply, though funding flows to U.S.-based entities. Independent investigators and small organizations may apply but must demonstrate institutional research support.
This mechanism explicitly excludes clinical trials. Proposed projects must focus on developing, enhancing, or distributing research tools, databases, models, animal colonies, tissue repositories, and analytical resources that support health research broadly.
Applicants must have established institutional infrastructure and the capacity to maintain and support the resource over the project period. Prior research experience and demonstrated expertise in the resource area strengthen applications significantly.
Not the right fit? Find grants for your organization in 5 questions →
Program description
The Office of Research Infrastructure Programs (ORIP) encourages grant applications aimed at developing, characterizing, or improving research models of human health and diseases; developing biology based new approach methodologies (NAMs) applicable to human health and diseases; or improving access to information about or generated from the use of models of human disease. The models, including NAMs, and related biological materials developed must be broadly applicable to the scientific interests of two or more NIH Institutes or Centers (ICs) and must evaluate diseases and processes that impact multiple organ systems in order to align with the ORIP”s NIH-wide mission and programs. Applications must describe the need for and the potential impact of the proposed resources on the research community across a range of scientific disciplines supported by multiple NIH ICs. Applications to develop models that relate strictly to a specific disease or a select area of research or that do not have a broad impact on the NIH-wide research community will not be accepted. Projects that predominantly address the research interests of one NIH IC but are only peripherally related to the research interests of other ICs will also not be accepted, if submitted in response to this notice of funding opportunity (NOFO).
Who can apply
Eligible applicants
How to apply
Application links
Key dates & requirements
Required documents
- SF-424 (R&R) form
- Project Narrative (Research Strategy)
- Budget and Budget Justification
- Institutional Support Letter
- Letters of Support from Resource Users
- Biographical Sketches (key personnel)
- Research Timeline and Milestones
- Resource Utilization Plan
- Sustainability Plan
Program contact
- 👤 National Institutes of Health
- 📧 ORIPDCM@mail.nih.gov
- 📞 301-402-2541
Funding track record
Recent awards under CFDA 93.351 from the last 3 years — real organizations that won funding through this same program.
Top 10 Largest Recent Awards
-
$203,025,735
-
$201,841,608
-
$191,271,017
-
$156,271,917
-
$150,172,413
-
$133,830,113
-
$129,717,894
-
$37,946,246
-
$37,475,785
-
$33,594,411
Top States by Funding
- OR 7 awards $290.0M
- CA 8 awards $266.7M
- WA 2 awards $232.0M
- TX 9 awards $228.2M
- LA 6 awards $189.8M
Source: USAspending.gov — federal spending transparency. Data covers last 3 years.
Funding history
Annual funding for this program — Federal obligations (CFDA 93.351). How funding has trended year over year.
| 2024 | $279,889,905 | |
| 2025 | $284,089,258 | |
| 2026 est. | $283,084,958 |
FAQ
Who can apply for an NIH R24 grant?
Research institutions, universities, medical schools, hospitals, and established research centers can apply. Applicants must demonstrate institutional capacity to support and maintain the proposed resource.
Are clinical trials eligible for this grant?
No. This R24 explicitly excludes clinical trial projects. The focus must be on developing research tools, models, and materials that support non-clinical research.
What types of resources does this grant fund?
Common examples include animal model colonies, tissue/biospecimen repositories, biostatistics platforms, data analysis tools, databases, and specialized research equipment accessible to the research community.
What makes an application competitive?
Demonstrate clear scientific need for the resource, existing institutional support, a plan to sustain the resource long-term, and evidence that many researchers will benefit from access.
How much funding is typically available?
NIH R24 grants vary widely, but typically support annual budgets ranging from $150,000 to $500,000 depending on the resource scope and complexity. Check the specific funding announcement for exact limits.
💡 Tips for applicants
- Emphasize the scientific community benefit, not single-lab benefit. Show how many researchers will access and use your resource.
- Include strong letters of support from researchers who will use the resource. This validates demand and impact.
- Develop a detailed sustainability plan. Explain how the resource will persist after NIH funding ends through institutional commitment or other revenue streams.
- Be specific about infrastructure, personnel, and management. Detail who will run the resource day-to-day and how it will be administered.
- Address access policies clearly. Explain how external researchers request and obtain access to your resource fairly and transparently.
⚠️ Common mistakes
Applications fail when they lack demonstrated community need or commitment letters from future users. Applicants often underestimate the management and support infrastructure required to maintain shared resources. Sustainability plans that rely solely on continued NIH funding, rather than diversified support, are frequently cited as weakness.
Similar grants
- OPEN Alcohol Research-Related Resource Award (R24 Clinical Trial Not Allowed) — National Institutes of Health
- OPEN NIAID Resource-Related Research Projects (R24 Clinical Trial Not Allowed) — National Institutes of Health
- OPEN NIGMS National and Regional Resources (R24 – Clinical Trial Not Allowed) — National Institutes of Health
- OPEN Development of Animal Models and Related Biological Materials for Research (R21 Clinical Trial Not Allowed) — National Institutes of Health
- OPEN Utilizing Equipment to Study Environmental Extrinsic Factors and Enhance Rigor and Reproducibility of Animal Research (R24, Clinical Trials Not-Allowed) — National Institutes of Health