Environmental Health

National Institute of Environmental Health Sciences
CFDA 93.113 Active Grant Cooperative Agreement

Open Opportunities (2)

Live Grants.gov opportunities funded under this program — you can apply now.

Program Funding

Annual program obligations reported to SAM.gov.

Latest annual funding (estimated)
$40.3M FY2026
$445.8M
FY24
$465.9M
FY25
$40.3M
FY26*
* estimated

Who has received this funding

Organizations awarded under CFDA 93.113 (USAspending.gov).

Program Objective

The mission of the National Institute of Environmental Health Sciences (NIEHS) is to research how the environment affects biological systems across the lifespan and to translate this knowledge to reduce disease and promote health.

Eligibility

Eligible Applicants

  • International Organization
  • Nonprofit Organization
  • Not-for-Profit Organization
  • For-Profit Organization

Research Grants, Cooperative Agreements, Science Education Grants, SBIR Grants, Independent Scientist Awards, Mentored Research Scientist Development Award, Mentored Clinical Scientist Development Award, and the Academic Career Awards: A university, college, hospital, State, local or tribal governments, nonprofit research institution, or for-profit organization may submit an application and receive a grant for support of research by a named principal investigator. Candidates for Academic Career Awards Awards and Midcareer Investigator Awards in Patient Oriented Research must have a doctoral degree and peer-reviewed, independent, research support at the time the award is made. Candidates for Mentored Clinical Scientist Development Awards and Mentored Patient Oriented Research Career Development Awards must have a clinical degree or its equivalent and must have initiated post graduate clinical training. Candidates holding a Ph.D. degree are ineligible. Candidates who have served as principal investigators on PHS-supported research projects are ineligible. A candidate for Academic Career Awards must have a clinical or research doctorate degree. Those eligible for the Development Award must be able to devote at least 75 percent effort. SBIR grants can be awarded only to domestic small businesses (entities that are independently owned and operated for profit, are not dominant in the field in which research is proposed, and have no more than 500 employees). Primary employment (more than one-half time) of the principal investigator must be with the small business at the time of award and during the conduct of the proposed project. In both Phase I and Phase II, the research must be performed in the U.S. and its possessions. STTR grants can be awarded only to domestic small business concerns (entities that are independently owned and operated for profit, are not dominant in the field in which research is proposed and have no more than 500 employees) which "partner" with a research institution in cooperative research and development. At least 40 percent of the project is to be performed by the small business concern and at least 30 percent by the research institution. In both Phase I and Phase II, the research must be performed in the U.S. and its possessions. To be eligible for funding, a grant application must be approved for scientific merit and program relevance by a scientific review group and a national advisory council. Centers: A university-based, nonprofit research institution, or for-profit organization proposing an integrated research program established to accomplish a stated mission, covering activities ranging from very basic research to the actual application of research results in the prevention and control of environmental health problems, may submit an application under the direction of a named Center Director. National Research Service Awards: (1) Nonprofit domestic organizations may apply for the Institutional NRSA; (2) Individual NRSA awardees must be nominated and sponsored by a public for-profit or nonprofit private institution having staff and facilities appropriate to the proposed research training program; (3) all awardees must be citizens or have been admitted to the United States for permanent residence; (4) to be eligible, predoctoral awardees must have completed the baccalaureate degree and postdoctoral awardees must have a professional or scientific degree (M.D., Ph.D., D.D.S., D.O., D.V.M., Sc.D., D.Eng., or equivalent domestic or foreign degree).

How to Apply

Award Procedure

Made on the basis of dual review by peer groups of all applications. The first level of reviews is by a study section for scientific merit. In addition, a national advisory council provides a secondary level of review for all applications. As required by P.L. 109-482, the NIH Health Reform Act of 2006, all research grant and cooperative agreements must undergo Advisory Council/Board review and approval prior to funding. Review of Individual NRSA applications by an Advisory Council/Board is not required. Final approval of these recommendations and decisions concerning funding are made by the Director, NIEHS.

Decision Timeline

  • Approval: > 180 Days

Receipt, review and approval processes range in length from six to nine months.

Program details & compliance

Description

Environmental exposures considered are exogenous, and range from chemical, physical, and biologically derived (non-pathogenic) factors experienced through inhalation, ingestion, or ocular or dermal contact, individually or as mixtures. Research supported includes the development of technologies to assess human environmental exposures and biological impacts of exposure; mechanistic understanding of exposures on biological systems including the use of environmentally derived analytes as probes of fundamental biological mechanisms; epidemiological studies of the health effects of environmental exposures including the interactions between environmental and genetic or other endogenous factors; community engaged research; and the identification of strategies to reduce the burden of exposure and improve human health at the individual and population levels. NIEHS supports training and career development throughout the career trajectory and the development of commercial tools and technologies through SBIR and STTR programs.

Mission Categories

Primary: Research and Development

Other categories:
General Health and MedicalHealth Education

Required Documentation

Applications must be signed by appropriate officials of the submitting institution. The cost principles for awards under this program are set forth in HHS regulations at 45 CFR 75, Subpart E and Appendix IX (hospitals) to Part 75. Commercial organizations are subject to the cost principles located at 48 CFR 31.2 Federal Acquisition Regulation. See the NIH Grants Policy Statement (NIH GPS) for further guidance on the applicability of cost principals (http://grants.nih.gov/grants/policy/nihgps/index.htm).

Reporting & Compliance

Audit Required
Yes — Determined at Time of Award
Records Retention
3 years

Applicable 2 CFR 200 Subparts

  • Subpart B — General Provisions
  • Subpart C — Pre-Federal Award Requirements
  • Subpart D — Post-Federal Award Requirements
  • Subpart E — Cost Principles
  • Subpart F — Audit Requirements

Contacts

David Balshaw, Ph.D.
(984) 287-3234
530 Davis Drive, Morrisville, NC 27560
Jenny L. Greer
(984) 287-3332
530 Davis Drive, Morrisville, NC 27560
Data from SAM.gov Federal Assistance Listings. Source published: 2026-01-28. Spec v2.0. Last synced: 2026-05-29 05:40:17.