Health and Extreme Weather Solutions-Focused Research Hubs (U54 – Clinical Trial Optional)
🏛 National Institutes of Health (HHS-NIH11)
✓ Free, no account · Source: Grants.gov · Last verified Jul 15, 2026
Can you apply?
This grant is for research institutions and multidisciplinary consortia focused on extreme weather health impacts.
Eligible applicants include academic institutions, research centers, state and local public health departments, community-based organizations, Tribal entities, health care systems, and emergency preparedness agencies. Applications must be led by multidisciplinary teams with non-academic partners demonstrating meaningful community engagement.
Research can span the translational continuum, from fundamental to implementation research. Projects should address health impacts of extreme weather (wildfire smoke, extreme heat, flooding, hurricanes, drought) affecting populations at heightened risk across the lifespan.
Award recipients must collaborate with HEW Research Coordination and Data Centers, participate in data harmonization, and contribute to cross-site dissemination activities.
Not the right fit? Find grants for your organization in 5 questions →
Key dates
- Jun 26, 2026 Applications open
- Jan 29, 2027 Application deadline in 197 days
- Dec 1, 2027 Award announced
- Dec 2, 2027 Project start
Program description
The National Institute of Environmental Health Sciences (NIEHS) intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications that propose translational research hubs with multiple highly integrated components focused on research, capacity building, and community/public health translation for regionally relevant topics related to the health impacts of extreme weather and cumulative exposures, including but not limited to wildfire smoke, extreme heat, flooding, hurricanes, drought, and other climate-related hazards affecting populations at heightened risk across the lifespan. Responsive applications will be led by a multidisciplinary team of investigators with non-academic partners, such as state and local public health departments, community-based organizations, Tribal entities, health care systems, and emergency preparedness agencies. Consortia of multiple institutions are encouraged, particularly those that demonstrate meaningful community engagement and balanced, mutually beneficial partnership structures. Research can be situated at different nodes on the translational research continuum, spanning from fundamental to implementation research with a focus on being problem-based and solutions oriented, and should clearly inform pathways to support implementation, scalability, and measurable public health impact. Award recipients will be expected to collaborate with the HEW Research Coordination and Data Center(s) and other members of the HEW Community of Practice, including participation in data harmonization efforts, shared metrics development, and cross-site dissemination activities. This NOFO will utilize the U54 activity code, that supports specialized centers that function as regional resources for targeted research initiatives, including support for infrastructure development, pilot projects, and partnerships with affected communities throughout the research lifecycle. The U54 is a cooperative agreement that anticipates substantial federal programmatic staff involvement to assist investigators in the achievement of project objectives, including coordination across funded hubs, strategic alignment with NIH priorities, and facilitation of cross-institute collaboration. Grant authorities that allow NIEHS to forecast this opportunity are as follows: 42 USC 285l (NIEHS specific); 42 USC sections 241 (NIH grant authorities).
Who can apply
Eligible applicants
- 501(c)(3) Public Charity
- City / Municipal Government
- Community Health Center
- County Government
- Nonprofits
- Private University
- Public Authority
- Public K-12 School
- Public University
- Researcher (independent)
- Small Business (SBA-defined)
- Special District
- State Government
- Tribal Nation
- Tribal Organization
Demographic focus
How to apply
Application links
Key dates & requirements
Required documents
- SF-424 (R&R) Federal Application Form
- Project Narrative
- Detailed Budget with Budget Justification
- Biographical Sketches (PD/PI and key personnel)
- Letters of Support/Commitment from partner organizations
- Data Management Plan
- Research Strategy
- Institutional Biosafety/IACUC approvals (if applicable)
Program contact
- 👤 NIEHS Division of Extramural Research and Training
- 📧 NOFO.Information@niehs.nih.gov
- 📞 Please contact via e-mail
Funding track record
Recent awards under CFDA 93.113 from the last 3 years — real organizations that won funding through this same program.
Top 10 Largest Recent Awards
-
$200,640,187
-
$49,163,443
-
$47,446,509
-
$44,785,560
-
$33,491,440
-
$32,623,202
-
$31,263,603
-
$30,390,185
-
$30,320,471
-
$29,228,555
Top States by Funding
- NC 10 awards $369.0M
- NY 11 awards $187.6M
- CA 11 awards $177.3M
- MA 7 awards $127.8M
- MD 5 awards $52.2M
Source: USAspending.gov — federal spending transparency. Data covers last 3 years.
Funding history
Annual funding for this program — Federal obligations (CFDA 93.113). How funding has trended year over year.
| 2024 | $445,816,844 | |
| 2025 | $465,862,818 | |
| 2026 est. | $40,301,265 |
FAQ
Who can apply for this grant?
Academic institutions, public health departments, community-based organizations, Tribal entities, and health systems leading multidisciplinary teams with non-academic partners. Consortia of multiple institutions are encouraged.
What types of research does this support?
Research on health impacts of extreme weather including wildfire smoke, extreme heat, flooding, hurricanes, and drought. Work can span from fundamental to implementation research with a solutions-oriented focus.
Are there cost-sharing requirements?
No cost-sharing is required for this award.
What is the award amount?
The maximum award is $2,000,000. Total funding pool is $18,000,000 across all awards.
What happens after award?
Recipients must collaborate with HEW Research Coordination Centers, participate in data harmonization, and contribute to cross-site dissemination and implementation activities.
💡 Tips for applicants
- Emphasize meaningful community partnerships and balanced structures with non-academic partners from day one. Show specific roles and decision-making authority for community members.
- Position your research as solutions-oriented and problem-based. Connect findings to clear implementation and scalability pathways for public health impact.
- Build a multidisciplinary team spanning relevant fields: environmental health, epidemiology, community health, emergency preparedness, and implementation science.
- Highlight your capacity to participate in data harmonization and cross-site collaboration. Show willingness to share data and metrics with the broader HEW Community of Practice.
- Focus on populations at heightened risk. Demonstrate how your hub will address health inequities related to extreme weather exposure across the lifespan.
⚠️ Common mistakes
Failing to include non-academic partners (public health, community, Tribal, healthcare, emergency agencies) as integrated team members rather than passive consultants. Proposing basic research without clear pathways to implementation and public health impact. Underestimating the collaborative demands; not addressing willingness to participate in cross-site data harmonization and HEW Community of Practice activities.
Similar grants
- OPEN Health and Extreme Weather Research Coordination and Data Center (U2C – Clinical Trial Not Allowed) — National Institutes of Health
- CLOSED Interdisciplinary Research Networks to Advance Biomedical Research on Resilience and Health Optimization — National Institutes of Health
- CLOSED Strategies to Improve Health Outcomes and Reduce Health Disparities in Rural Populations (R01 Clinical Trial Optional) — National Institutes of Health
- CLOSED Forecast to Publish a Notice of Funding Opportunity Announcement for Addressing Determinants of Health Disparities Among Rural Populations (R01 – Clinical Trial Optional) — National Institutes of Health
- OPEN Limited Competition: Supporting Programs to Advance Research Knowledge in Environmental Health Sciences (SPARK-EHS) (UE5/T32 – Clinical Trial Not Allowed) — National Institutes of Health