Accelerating Discovery through Partnered Research with All of Us to Analyze Participant Biospecimens
Can you apply?
This grant is for research institutions and healthcare organizations to conduct biospecimen research using the All of Us Research Program database. Eligible applicants include academic medical centers, research universities, government labs, and 501(c)(3) research organizations. The focus is biomedical research utilizing All of Us participant data and samples. Geographic scope is nationwide for U.S.-based institutions. Researchers must have institutional affiliation and IRB approval capability.
Key dates
- Jan 8, 2026 Applications open
- Jun 1, 2026 Application deadline today
- Sep 18, 2026 Award announced
- Sep 18, 2026 Project start
This grant is for research institutions and healthcare organizations to conduct biospecimen research using the All of Us Research Program database. Eligible applicants include academic medical centers, research universities, government labs, and 501(c)(3) research organizations. The focus is biomedical research utilizing All of Us participant data and samples. Geographic scope is nationwide for U.S.-based institutions. Researchers must have institutional affiliation and IRB approval capability.
Program description
The All of Us Research Program seeks to advance its mission by enabling access to biospecimens stored in the All of Us supported Biobank for researchers to conduct assays to evaluate associations between biomarkers and chronic diseases and add data to the All of Us resource for broad use by researchers. Biomarker analysis includes, but is not limited to, biomarker discovery; biomarker validation; novel disease stratification; and multiomics integration for disease risk, diagnosis, and prognosis, in support of advancing precision medicine. The All of Us Research Program is a historic effort to enroll 1 million participants who share data to accelerate research and medical breakthroughs, and enable individualized prevention, treatment, and care. Researchers use data from the program to learn more about how individual differences in lifestyle, environment, and genetics can influence health and disease.
Grant authorities that allow the All of Us Research Program to forecast this opportunity are as follows: 42 USC 241 and 284.
Who can apply
Eligible applicants
- 501(c)(3) Public Charity
- City / Municipal Government
- County Government
- Nonprofits
- Private University
- Public Authority
- Public K-12 School
- Public University
- Small Business (SBA-defined)
- Special District
- State Government
- Tribal Nation
- Tribal Organization
Details
This grant is for research institutions and healthcare organizations to conduct biospecimen research using the All of Us Research Program database. Eligible applicants include academic medical centers, research universities, government labs, and 501(c)(3) research organizations. The focus is biomedical research utilizing All of Us participant data and samples. Geographic scope is nationwide for U.S.-based institutions. Researchers must have institutional affiliation and IRB approval capability.
How to apply
Application links
Key dates & requirements
Required documents
- SF-424 (R&R) Application Form
- Project Narrative and Specific Aims
- Budget and Budget Justification
- Biosketch for Key Personnel
- Letters of Institutional Commitment
- IRB Approval or Approval Letter
- Research Plan with Methods and Timeline
- Data Management and Security Plan
Program contact
- 👤 All of Us Research Program, Innovative Collaborations and Ancillary Studies Branch
- 📧 AoUAncillaryStudies@od.nih.gov
- 📞 Please contact via e-mail (Subject: AllofUsX01).
Funding track record
Recent awards under CFDA 93.368 from the last 3 years — real organizations that won funding through this same program.
Top 10 Largest Recent Awards
-
$202,512,667
-
$180,342,068
-
$46,033,133
-
$35,032,066
-
$28,405,106
-
$26,220,039
-
$14,314,808
-
$13,790,870
-
$13,330,548
-
$8,197,106
Top States by Funding
- CA 8 awards $249.8M
- MN 2 awards $180.6M
- WI 3 awards $46.7M
- SC 1 awards $35.0M
- NY 3 awards $29.1M
Source: USAspending.gov — federal spending transparency. Data covers last 3 years.
Funding history
Annual funding for this program — Federal obligations (CFDA 93.368). How funding has trended year over year.
| 2024 | $349,050,699 | |
| 2025 | $196,703,226 | |
| 2026 est. | $153,000,000 |
FAQ
Who can apply for this grant?
Academic institutions, research universities, government labs, and nonprofit research organizations with 501(c)(3) status. Applicants must have institutional research infrastructure and IRB oversight.
What type of research does this support?
Biomedical and translational research using All of Us participant biospecimens and associated health data. Studies analyzing genetic, molecular, or phenotypic data are prioritized.
Is prior All of Us experience required?
Not necessarily. New researchers are encouraged. You should demonstrate capacity to work with protected health information and genomic data.
What budget range should I expect?
Typical NIH R21 and R01 mechanisms range from $100K-$500K annually. Consult the specific funding opportunity announcement for exact limits.
What is the timeline for review and funding?
Standard NIH peer review takes 4-6 months after deadline. If approved, funding typically begins 6-8 months after submission.
💡 Tips for applicants
- Demonstrate your team's experience with biospecimen handling and genomic analysis. Include relevant publications and preliminary data.
- Clearly explain how your research uses All of Us data uniquely. Show alignment with All of Us research priorities.
- Build a collaborative team. Include biostatisticians, clinicians, and data managers as appropriate.
- Plan for data security and privacy compliance. Detail your IRB and HIPAA protocols upfront.
- Start early building your All of Us researcher account and accessing the database. Familiarize yourself with available datasets before drafting.
⚠️ Common mistakes
Underestimating complexity of All of Us data access and governance requirements. Not securing institutional commitment and IRB pre-approval before submission. Proposing research scope too broad or unfocused given biospecimen availability constraints.
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