21st Century Cures Act – Precision Medicine Initiative

All of Us Research Program
CFDA 93.368 Active Other Financial Assistance

Program Funding

Annual program obligations reported to SAM.gov.

Latest annual funding (estimated)
$153M FY2026
$349.1M
FY24
$196.7M
FY25
$153M
FY26*
* estimated

Who has received this funding

Organizations awarded under CFDA 93.368 (USAspending.gov).

Program Objective

To provide support for initiatives funded under the 21st Century Cures Act, the All of Us Research Program will gather data from one million or more diverse people living in the United States to accelerate research and improve health. By taking into account individual differences in lifestyle, environment, and biology, researchers will uncover paths toward delivering precision medicine.

Eligibility

Eligible Applicants

  • Unrestricted by Entity Type

The awardee will be a university, college, hospital, public agency, nonprofit research institution or for-profit organization that applies and receives an award for support of research by a named principal investigator. To be eligible for funding, a grant application must be approved for scientific merit and program relevance by a scientific review group and a national advisory council.

Beneficiaries

  • Unrestricted by Entity Type

Any nonprofit or for-profit organization, company, or institution engaged in biomedical research.

How to Apply

Application Procedure

2 CFR 200, Uniform Administrative
Requirements, Cost Principles, and Audit Requirements for Federal Awards applies
to this program. For Grants and Cooperative Agreements, 2 CFR 200, Uniform
Administrative Requirements, Cost Principles, and Audit Requirements for Federal
Awards applies to this program. For Other Transactions, Section 402 (n) of the
Public Health Service Act, 42 U.S.C. 282 (n) apply to this program.

Award Procedure

Grants and cooperative agreements are funded based on scientific merit, program relevance, and program balance and are made annually. The initial grant award provides funds for the first budget period (usually 12 months) and letter Notice of Award indicates support recommended for the remainder of the project period, allocation of Federal funds by budget categories and special conditions, if any. Other Transactions are awarded based on the criteria stated within the research opportunity announcement for each initiative.

Grants/Cooperative Agreements: Approximately 10 months. Other Transactions: varies

Program details & compliance

Description

The All of Us Research Program will gather data from one million or more people
living in the United States to accelerate research and improve health. By taking into
account individual differences in lifestyle, environment, and biology, researchers
will uncover paths toward delivering precision medicine.

Mission Categories

Primary: Research and Development

Use of Funds

Allowed Uses

Other Transactions, Contracts, IAAs, Grants and cooperative agreements may be made to eligible institutions for the support of the All of Us Research Program projects. The awards may be used for personnel, consultant costs, equipment, supplies, travel, patient costs, animals, alterations and renovations, miscellaneous items, and Facilities and Administrative Costs (formerly known as indirect costs).

Required Documentation

Applications must be submitted in compliance with instructions provided with each initiative.

Reporting & Compliance

Audit Required
Yes — Determined at Time of Award
Records Retention
6 years

Applicable 2 CFR 200 Subparts

  • Subpart B — General Provisions
  • Subpart C — Pre-Federal Award Requirements
  • Subpart D — Post-Federal Award Requirements
  • Subpart E — Cost Principles
  • Subpart F — Audit Requirements

Contacts

JUSTIN HENTGES
3015940651
National Institutes of Health 6011 Executive Blvd, Suite 214, ROCKVILLE, MD 20852
Data from SAM.gov Federal Assistance Listings. Source published: 2026-01-28. Spec v2.0. Last synced: 2026-05-29 05:39:59.