The NIDDK Disorders of Gastrointestinal Interoception Consortium Clinical Centers (DGIC)
🏛 National Institutes of Health (HHS-NIH11)
✓ Free, no account · Source: Grants.gov · Last verified Jul 15, 2026
Can you apply?
This grant is for research institutions seeking to establish clinical research centers studying gastrointestinal interoception disorders. Eligible applicants include academic medical centers, research hospitals, and university-affiliated institutions capable of conducting clinical research. The consortium will support up to 6 Clinical Research Centers investigating how the nervous system senses and interprets gastrointestinal signals across adult and pediatric populations.
Activities include recruiting and studying patients with functional GI disorders, building registries and databases, identifying biomarkers and therapeutic targets, and using multidisciplinary teams to understand disease mechanisms. The work spans gastroenterology, neurology, and basic science approaches.
This is a cooperative agreement requiring active collaboration with NIDDK program staff. Applicants must demonstrate capacity for patient recruitment, clinical data collection, and long-term follow-up studies.
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Key dates
- Sep 18, 2025 Applications open
- Nov 1, 2026 Application deadline in 108 days
- Jul 1, 2027 Award announced
- Jul 1, 2027 Project start
Program description
The National Institute of Diabetes and Digestive Diseases and Nutrition (NIDDK) seeks to advance its mission by continuing the work of the NIDDK Gastroparesis Consortium (GpCRC) but also to expand its scope. The collaborative efforts of the GpCRC provided a large database, the Gastroparesis Registry, which is located in the NIDDK central repository and contains information on patients with symptoms of either delayed or normal gastric emptying. It also houses the first U.S. registry of children and adolescents with gastroparesis. The GpCRC provided clarity and insight that set the stage for transforming our understanding of gastroparesis and laid out a road map for approaching other disorders of gastrointestinal (GI) motility. The findings from clinical studies and trials clearly demonstrated that the clinical burden of gastroparesis is significantly greater than previously realized and involves much more than the stomach. Importantly, the underlying mechanisms remain unclear.
Interoception is the ability of the nervous system to sense, interpret and coordinate signals from various bodily systems including the gastrointestinal tract. Many functional GI disorders are associated with a spectrum of overlapping symptoms including nausea, vomiting, and altered bowel habits all of which involve altered interoceptive signaling. This initiative would broaden the scope beyond gastroparesis to include other adult and pediatric GI conditions associated with impaired interoceptive processing to form a Disorders of Gastrointestinal Interoception Consortium (DGIC). The consortium may include up to 6 Clinical Research Centers and a Scientific Data Research Center (SDRC, described in a companion notice). There would be an emphasis on multidisciplinary approaches that would reveal the underlying mechanisms that connect GI function (e.g motility) more directly to symptoms, identify disease or response biomarkers that assess treatment efficacy, and leverage state-of-the-art technologies to identify novel therapeutic targets that could be assessed in future clinical trials.
Who can apply
Eligible applicants
How to apply
Application links
Key dates & requirements
Required documents
- SF-424 Federal grant application form
- Project Narrative describing research approach and mechanisms
- Detailed budget and justification
- Key personnel biosketches
- Institutional commitment letters
- Letters of support from collaborating departments
- Data management plan
- Patient recruitment and retention strategy
Program contact
- 👤 Terez Shea-Donohue, Ph.D.
- 📧 terez.shea-donohue@nih.gov
- 📞 301-825-2314
Funding track record
Recent awards under CFDA 93.847 from the last 3 years — real organizations that won funding through this same program.
Top 10 Largest Recent Awards
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$438,527,853
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$200,221,259
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$152,979,352
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$112,529,392
-
$66,521,567
-
$45,186,589
-
$39,699,167
-
$37,490,770
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$34,242,949
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$31,624,784
Top States by Funding
- WA 3 awards $492.3M
- NC 4 awards $291.6M
- FL 2 awards $184.1M
- MA 6 awards $168.4M
- PA 6 awards $168.1M
Source: USAspending.gov — federal spending transparency. Data covers last 3 years.
Funding history
Annual funding for this program — Federal obligations (CFDA 93.847). How funding has trended year over year.
| 2024 | $1,971,472,000 | |
| 2025 | $2,043,166,000 | |
| 2026 est. | $111,289,000 |
FAQ
Who can apply for this grant?
Academic medical centers, research hospitals, and university-affiliated institutions with strong clinical research infrastructure. Your institution must have gastroenterology expertise and capacity for patient recruitment and long-term follow-up.
What is the funding mechanism?
This is a cooperative agreement, not a traditional grant. NIDDK staff will work actively with your research team throughout the project.
What research activities are supported?
Clinical studies of gastrointestinal interoception disorders, patient registry development, biomarker identification, and mechanistic studies using multidisciplinary approaches. Both adult and pediatric populations are included.
How many centers will be funded?
Up to 6 Clinical Research Centers will be funded, plus 1 Scientific Data Research Center (in a companion notice). This is a consortium model with coordinated research efforts.
What is the total funding pool?
$3 million is available for the entire consortium. Individual center awards are not specified in the notice.
💡 Tips for applicants
- Emphasize your institution's track record recruiting and retaining GI patient populations for long-term studies. Show patient recruitment strategies and retention rates from past studies.
- Build a strong multidisciplinary team including gastroenterologists, neurologists, basic scientists, biostatisticians, and patient advocates. Cooperative agreements require active team collaboration.
- Detail your data management and registry infrastructure. NIDDK values centers that can contribute to centralized databases and long-term follow-up systems.
- Clearly articulate how your center will advance understanding of disease mechanisms. Move beyond symptom description to explain how you'll identify biomarkers and therapeutic targets.
- Coordinate early with NIDDK program staff before submitting. Cooperative agreements benefit from preliminary discussions about research priorities and scientific approach.
⚠️ Common mistakes
Applications fail when institutions lack demonstrated gastroenterology research capacity or patient recruitment infrastructure. Weak multidisciplinary collaboration among team members is a major red flag. Centers that propose isolated research without connecting to the consortium's shared goals and data systems typically score lower. Vague descriptions of biomarker or therapeutic target strategies hurt competitiveness.
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