Disease Research and Translational Core Centers (P30 Clinical Trial Optional)
🏛 National Institutes of Health (HHS-NIH11)
✓ Free, no account · Source: Grants.gov · Last verified Jul 15, 2026
Can you apply?
This grant is for research institutions seeking to establish multidisciplinary biomedical and translational research centers. Applicants must have a large, established research base in cystic fibrosis, diabetes, nutrition, obesity, liver, or digestive diseases. Institutions must demonstrate capacity to provide shared research cores, pilot funding programs, and mentoring for early-stage investigators. The P30 mechanism supports collaborative research infrastructure that enhances rigor and research efficiency across a center's research community.
Eligible applicants are typically domestic research institutions including universities, medical centers, and independent research organizations. International organizations may have limited eligibility. Applications must show institutional commitment to the research focus area and capacity to manage a multidisciplinary center with shared research resources.
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Key dates
- Jul 2, 2026 Applications open
- Jun 1, 2027 Application deadline in 320 days
- Mar 31, 2028 Award announced
- Apr 28, 2028 Project start
Program description
This Notice of Funding Opportunity (NOFO) invites applications for NIDDK Disease Research and Translational Core Centers (P30 Clinical Trial Optional). These Core Centers are part of an integrated program of biomedical and translational research supporting our cystic fibrosis, diabetes, nutrition, obesity, liver and digestive diseases research. They enhance multidisciplinary collaboration, rigor, reproducibility, replication and research cost efficiencies at institutions that already have a large established research base in one of the above focused areas within NIDDK’s mission. They should also provide a rich mentoring environment for trainees and early-stage investigators. The P30 Centers accomplish their purpose by providing a Pilot and Feasibility Grant Program, a Scientific Catalyst Program, and importantly shared access to the services of Cores. Within a given P30 Center, the Scientific Catalyst Program, which works within the Administrative Core, supports activities that strengthen the Center’s scientific community and advance its research mission. Activities may include research team building, investigator mentoring, seminars, workshops, visiting scientists, and scientific research series. The program is intended to foster multidisciplinary collaboration, attract new investigators, and engage investigators with expertise relevant to the Center’s chronic disease research focus. The Core Services reflect the research needs of the Center and may include research consultation along with services involving cell or other models, planning, analysis, hands-on services, access to expensive specialized equipment, other technical resources or training shared by the Center members and operated or overseen by recognized experts.
Who can apply
Eligible applicants
How to apply
Application links
Key dates & requirements
Required documents
- SF-424 (R&R) Application Form
- Program Narrative (Project Description)
- Budget Narrative and Budget Forms (SF-424 R&R)
- Biographical Sketches (all key personnel)
- Institutional Support Letter
- Research Core Descriptions and Operations Plans
- Letters of Support from Participating Investigators
- Evidence of Institutional Commitment
Program contact
- 👤 NIDDK_P30s@NIH.gov
- 📧 NIDDK_P30s@NIH.gov
- 📞 NIDDK_P30s@NIH.gov
Funding track record
Recent awards under CFDA 93.847 from the last 3 years — real organizations that won funding through this same program.
Top 10 Largest Recent Awards
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$438,527,853
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$200,221,259
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$152,979,352
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$112,529,392
-
$66,521,567
-
$45,186,589
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$39,699,167
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$37,490,770
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$34,242,949
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$31,624,784
Top States by Funding
- WA 3 awards $492.3M
- NC 4 awards $291.6M
- FL 2 awards $184.1M
- MA 6 awards $168.4M
- PA 6 awards $168.1M
Source: USAspending.gov — federal spending transparency. Data covers last 3 years.
Funding history
Annual funding for this program — Federal obligations (CFDA 93.847). How funding has trended year over year.
| 2024 | $1,971,472,000 | |
| 2025 | $2,043,166,000 | |
| 2026 est. | $111,289,000 |
FAQ
What is the difference between a P30 Center and other NIH mechanisms?
P30 Centers fund research infrastructure, shared cores, and pilot programs rather than individual research projects. They support a collaborative research environment across multiple investigators within an institution.
Who should lead a P30 application?
An experienced principal investigator with substantial research credentials in one of NIDDK's disease focus areas should lead the center. Co-leaders and core directors should have complementary expertise.
What must a P30 Center provide?
Centers must offer a Pilot and Feasibility Program, Scientific Catalyst Program, Administrative Core, and disease-specific Research Cores. Shared services should be accessible to all Center members.
How competitive is this funding?
P30 Centers are highly competitive. Success requires demonstrated institutional research strength, innovative core services, and clear mentoring plans for trainees and early-stage investigators.
What is the expected award level?
Direct costs typically range from $500,000 to $1,500,000 per year, but check the current NOFO for exact funding range. Awards support core services, administrative costs, and pilot grants.
💡 Tips for applicants
- Demonstrate your institution's research strengths with publications, funding history, and facilities in your disease focus area. Show critical mass of researchers ready to participate.
- Design research cores that address genuine bottlenecks for your Center members. Include specific equipment, expertise, and services that enable collaborative research.
- Create a compelling Pilot and Feasibility Program that launches high-risk, high-impact projects likely to generate future funding. Include clear review criteria and success metrics.
- Build a robust Scientific Catalyst Program that brings investigators together across disciplines. Include seminars, workshops, and mentoring that strengthen your research community.
- Establish a strong management structure with experienced leadership, clear governance, and accountability mechanisms. Define decision-making processes and resource allocation strategies.
⚠️ Common mistakes
Many applications propose cores that duplicate existing university services rather than addressing unique Center needs. Weak pilot programs lack clear metrics for selecting and evaluating pilot projects. Applicants underestimate administrative costs and fail to budget adequately for core director expertise.
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