Silvio O. Conte Digestive Diseases Research Core Centers (P30-Clinical Trial Optional)
🏛 National Institutes of Health (HHS-NIH11)
✓ Free, no account · Source: Grants.gov · Last verified Jul 15, 2026
Can you apply?
This grant is for institutions and research centers seeking to establish or maintain high-quality digestive diseases research facilities and infrastructure. Applicants must be research institutions, universities, or medical centers with the capacity to conduct NIH-funded research and house shared research core facilities. The program supports collaborative research centers focusing on gastrointestinal, liver, and pancreatic diseases. Eligible applicants include public and private nonprofit organizations, state and local governments, and eligible for-profit organizations. The grant requires a strong institutional commitment to digestive diseases research and the ability to provide shared resources and cores that support multiple research projects and investigators.
Not the right fit? Find grants for your organization in 5 questions →
Key dates
- Jun 16, 2026 Applications open
- Feb 10, 2027 Application deadline in 209 days
- Jun 1, 2027 Award announced
- Jun 1, 2027 Project start
Program description
This Notice of Funding Opportunity (NOFO) invites applications for Silvio O. Conte Digestive Diseases Research Core Centers (DDRCCs). The DDRCCs are part of an integrated program of digestive and liver diseases research support provided by the NIDDK. The purpose of this Centers program is to bring together basic and clinical investigators to enhance communication, collaboration, and effectiveness of ongoing research related to digestive and/or liver diseases within the NIDDK’s mission. DDRCCs are based on the core concept, whereby shared resources aimed at fostering productivity, synergy, and new research ideas among the funded investigators are supported in a cost-effective manner. Each proposed DDRCC must be organized around a central theme that reflects the focus of the digestive or liver diseases research of the Center members. The central theme must be within the primary mission of the NIDDK, and not thematic areas for which other NIH Institutes or Centers are considered the primary source of NIH funding.
Who can apply
Eligible applicants
How to apply
Application links
Key dates & requirements
Required documents
- SF-424 (R&R) Federal Application for Research and Related Activities
- Project narrative (describing each core, operations, quality assurance, staffing)
- Detailed budget and budget justification
- Biosketches of core directors and key personnel
- Letters of institutional support and commitment
- Letters of support from faculty/investigators who will use the cores
- IRB or IACUC approval documentation (if applicable)
- Facilities and resources description with cost-sharing details
- Data management and sharing plan
- Vertebrate animal care plan (if applicable)
Program contact
- 👤 Katrina J. Serrano, Ph.D.
- 📧 katrina.serrano@nih.gov
- 📞 301-480-7855
Funding track record
Recent awards under CFDA 93.847 from the last 3 years — real organizations that won funding through this same program.
Top 10 Largest Recent Awards
-
$438,527,853
-
$200,221,259
-
$152,979,352
-
$112,529,392
-
$66,521,567
-
$45,186,589
-
$39,699,167
-
$37,490,770
-
$34,242,949
-
$31,624,784
Top States by Funding
- WA 3 awards $492.3M
- NC 4 awards $291.6M
- FL 2 awards $184.1M
- MA 6 awards $168.4M
- PA 6 awards $168.1M
Source: USAspending.gov — federal spending transparency. Data covers last 3 years.
Funding history
Annual funding for this program — Federal obligations (CFDA 93.847). How funding has trended year over year.
| 2024 | $1,971,472,000 | |
| 2025 | $2,043,166,000 | |
| 2026 est. | $111,289,000 |
FAQ
Who is eligible to apply for this grant?
Research institutions, academic medical centers, and universities with documented capacity to conduct NIH-funded research and support shared research cores. Nonprofit organizations and government entities may also apply if they meet NIH eligibility requirements.
What types of research cores can be supported?
The program funds shared research facilities and cores that advance digestive diseases research, such as histology cores, animal model cores, imaging cores, molecular biology cores, and bioinformatics cores that serve multiple investigators.
What is the typical funding range for this grant?
NIH Research Core Centers typically award $250,000 to $500,000 per year, though amounts vary based on the scope and complexity of proposed cores. Multi-year budgets are common.
How competitive is this grant?
This is a highly competitive NIH grant program. Success requires a well-developed research center concept, strong institutional support, experienced leadership, and evidence of demand for the proposed cores from multiple research groups.
When are applications due?
Check grants.nih.gov for current deadlines, as this program typically has specific receipt dates. The application opens September 2, 2025.
💡 Tips for applicants
- Demonstrate clear demand: Document letters of support from multiple faculty members and research groups that will use the proposed cores, showing genuine need and utilization projections.
- Emphasize shared resources: Clearly articulate how your cores will serve 5+ independent research projects and multiple investigators, not just a single lab or program.
- Build strong institutional commitment: Secure letters committing institutional funds, space, equipment, and administrative support to supplement federal funding and ensure sustainability.
- Develop detailed core operations plans: For each proposed core, provide standard operating procedures, quality assurance metrics, equipment specifications, and staffing plans to demonstrate readiness.
- Address digestive diseases expertise: Highlight your institution's existing strength in GI, liver, and pancreatic disease research and how the cores will expand research capacity in these areas.
⚠️ Common mistakes
Applications often lack sufficient institutional commitment documentation or fail to demonstrate genuine demand from multiple independent research groups. Weak core leadership (cores should have experienced directors), poorly defined quality metrics, and insufficient detail on how costs were calculated are also common reasons for rejection. Additionally, applicants sometimes propose cores that duplicate existing resources rather than filling genuine gaps.
Similar grants
- OPEN NIDDK Disease Research and Translational Core Centers (P30 Clinical Trial Optional) — National Institutes of Health
- OPEN Environmental Health Sciences Core Centers Program (P30 Clinical Trials Optional) — National Institutes of Health
- OPEN The NIDDK Disorders of Gastrointestinal Interoception Consortium Clinical Centers (DGIC) — National Institutes of Health
- OPEN KUH P30 Resource Core Center (P30 Clinical Trial Not Allowed) — National Institutes of Health
- CLOSED Pancreatic Cancer Detection Consortium: Management and Data Coordination Unit (U24 Clinical Trial Not Allowed) — National Institutes of Health