The NIDDK Disorders of Gastrointestinal Interoception Consortium Clinical Centers (DGIC)
🏛 National Institutes of Health (HHS-NIH11)
✓ Free, no account · Source: Grants.gov · Last verified Jul 15, 2026
Can you apply?
This grant is for institutions conducting clinical research on gastrointestinal interoception disorders. Eligible applicants typically include NIH-grantable research institutions: universities, medical centers, teaching hospitals, and nonprofit research organizations with established research infrastructure.
The consortium structure includes up to 6 Clinical Research Centers plus 1 Scientific Data Research Center. Each center needs multidisciplinary expertise in GI disorders, interoceptive physiology, and clinical research methodology.
Applicants must demonstrate capacity for patient enrollment, biospecimen collection, data management, and participation in a collaborative network. This is a consortium-based program requiring coordination with other research centers.
Not the right fit? Find grants for your organization in 5 questions →
Key dates
- Sep 18, 2025 Applications open
- Nov 1, 2026 Application deadline in 108 days
- Jul 1, 2027 Award announced
- Jul 1, 2027 Project start
Program description
The National Institute of Diabetes and Digestive Diseases and Nutrition (NIDDK) seeks to advance its mission by continuing the work of the NIDDK Gastroparesis Consortium (GpCRC) but also to expand its scope. The collaborative efforts of the GpCRC provided a large database, the Gastroparesis Registry, which is located in the NIDDK central repository and contains information on patients with symptoms of either delayed or normal gastric emptying. It also houses the first U.S. registry of children and adolescents with gastroparesis. The GpCRC provided clarity and insight that set the stage for transforming our understanding of gastroparesis and laid out a road map for approaching other disorders of gastrointestinal (GI) motility. The findings from clinical studies and trials clearly demonstrated that the clinical burden of gastroparesis is significantly greater than previously realized and involves much more than the stomach. Importantly, the underlying mechanisms remain unclear.
Interoception is the ability of the nervous system to sense, interpret and coordinate signals from various bodily systems including the GI tract. Many functional GI disorders are associated with a spectrum of overlapping symptoms including nausea, vomiting, and altered bowel habits all of which involve altered interoceptive signaling. This initiative would broaden the scope beyond gastroparesis to include other adult and pediatric GI conditions associated with impaired interoceptive processing to form a Disorders of Gastrointestinal Interoception Consortium (DGIC). The consortium may include up to 6 Clinical Research Centers (described in a companion notice) and a Scientific Data Research Center (SDRC). There would be an emphasis on multidisciplinary approaches that would reveal the underlying mechanisms that connect GI function more directly to symptoms, identify disease or response biomarkers that assess treatment efficacy, and leverage state-of-the-art technologies to identify novel therapeutic targets that could be assessed in future clinical trials. The SDRC will coordinate collaboration among the Clinical Research Centers, participant enrollment, biospecimen collections and processing, and manage the submission of data and samples to central databases and repositories.
Who can apply
Eligible applicants
How to apply
Application links
Key dates & requirements
Required documents
- NIH Form 424 (R&R)
- Project Narrative/Research Plan
- Budget and Budget Justification
- Biographical Sketches (key personnel)
- Institutional Support Letter
- Letters of Collaboration (from consortium partner institutions)
- Data Management and Sharing Plan
- Biospecimen Collection and Processing Protocol
- Vertebrate Animals or Human Subjects documentation (if applicable)
Program contact
- 👤 Terez Shea-Donohue, Ph.D.
- 📧 terez.shea-donohue@nih.gov
- 📞 301-825-2314
Funding track record
Recent awards under CFDA 93.847 from the last 3 years — real organizations that won funding through this same program.
Top 10 Largest Recent Awards
-
$438,527,853
-
$200,221,259
-
$152,979,352
-
$112,529,392
-
$66,521,567
-
$45,186,589
-
$39,699,167
-
$37,490,770
-
$34,242,949
-
$31,624,784
Top States by Funding
- WA 3 awards $492.3M
- NC 4 awards $291.6M
- FL 2 awards $184.1M
- MA 6 awards $168.4M
- PA 6 awards $168.1M
Source: USAspending.gov — federal spending transparency. Data covers last 3 years.
Funding history
Annual funding for this program — Federal obligations (CFDA 93.847). How funding has trended year over year.
| 2024 | $1,971,472,000 | |
| 2025 | $2,043,166,000 | |
| 2026 est. | $111,289,000 |
FAQ
Who can apply as a Clinical Research Center?
Universities, medical schools, hospitals, and nonprofit research institutions with established GI research programs and patient populations. You must have multidisciplinary clinical expertise and infrastructure for biospecimen collection.
What is the Scientific Data Research Center role?
The SDRC coordinates all consortium activities, manages participant enrollment, processes biospecimens, and maintains central databases and repositories for all participating centers.
What clinical populations can we study?
The consortium covers adult and pediatric disorders of GI interoception, including gastroparesis and related functional GI disorders. Emphasis is on conditions with impaired interoceptive signaling.
How competitive is this funding?
This is a highly competitive consortium program from NIH. Strong preliminary data, experienced research team, and clear mechanistic focus on interoception are essential for success.
Is there a limit to project duration?
The funding instrument is a cooperative agreement, typically providing multi-year support. Specific duration and renewal terms are outlined in the full RFP.
💡 Tips for applicants
- Start planning your application immediately. Build or strengthen partnerships with other institutions that could serve as consortium centers.
- Focus on the interoception angle—clearly explain how your research addresses nervous system signaling in GI disorders, not just GI function alone.
- Highlight your patient population and enrollment capacity. Show you can recruit and retain participants across multiple conditions.
- Invest in detailed biospecimen collection protocols and storage infrastructure. This consortium requires rigorous sample management and sharing.
- Develop a strong data management plan that shows how your center will contribute to and benefit from the central repository and databases.
⚠️ Common mistakes
Applications lack clear mechanistic focus on interoception and present only descriptive clinical studies without biomarker or pathway discovery. Centers overestimate enrollment capacity without realistic infrastructure or fail to demonstrate multidisciplinary expertise needed for consortium work. Proposals ignore the collaborative data-sharing and coordination requirements central to consortium success.
Similar grants
- OPEN The NIDDK Disorders of Gastrointestinal Interoception Consortium Clinical Centers (DGIC) — National Institutes of Health
- OPEN The NIDDK Inflammatory Bowel Disease Genetics Consortium (IBDGC) Genomic Research Centers — National Institutes of Health
- OPEN Silvio O. Conte Digestive Diseases Research Core Centers (P30-Clinical Trial Optional) — National Institutes of Health
- OPEN NIDDK Disease Research and Translational Core Centers (P30 Clinical Trial Optional) — National Institutes of Health
- OPEN The NIDDK Inflammatory Bowel Disease Genetics Consortium (IBDGC) Data Coordinating Center — National Institutes of Health