SIREN Neurologic Clinical Trials (UG3/UH3 – Clinical Trial Required)
Can you apply?
This grant is for institutions conducting NIH-supported clinical trials in neurology and neurological disorders. Eligible applicants include academic medical centers, research hospitals, and academic institutions with established clinical research infrastructure. The program supports the planning phase (UG3) and clinical trial execution phase (UH3) of investigator-initiated neurologic research. A formal clinical trial is required for all applications.
This grant is for institutions conducting NIH-supported clinical trials in neurology and neurological disorders. Eligible applicants include academic medical centers, research hospitals, and academic institutions with established clinical research infrastructure. The program supports the planning phase (UG3) and clinical trial execution phase (UH3) of investigator-initiated neurologic research. A formal clinical trial is required for all applications.
Program description
This announcement (NOFO) encourages applications for multi-center clinical trials focused on neurological emergencies. Successful applicants will collaborate and conduct the trial within the NIH SIREN Network. The NIH SIREN Clinical Coordinating Center (CCC) will work with the successful applicants to implement the proposed trial efficiently and the SIREN Data Coordinating Center (DCC) will provide statistical and data management support. The NIH SIREN hubs and their affiliated clinical sites will provide on-site implementation of the clinical protocols.The NIH SIREN Network will also be uniquely poised to collaborate with other US and international consortia necessary to conduct larger, definitive trials of promising interventions for neurological emergencies.Multi-center clinical trials in stroke treatment, recovery, or prevention supported by NINDS will be conducted in the NIH StrokeNet, and not within SIREN. Applicants do not need to be part of the existing SIREN infrastructure to apply under this FOA.
Who can apply
Eligible applicants
- 501(c)(3) Public Charity
- City / Municipal Government
- Colleges (all higher ed)
- County Government
- Nonprofits
- Private University
- Public Authority
- Public K-12 School
- Public University
- Small Business (SBA-defined)
- Special District
- State Government
- Tribal Nation
- Tribal Organization
Details
This grant is for institutions conducting NIH-supported clinical trials in neurology and neurological disorders. Eligible applicants include academic medical centers, research hospitals, and academic institutions with established clinical research infrastructure. The program supports the planning phase (UG3) and clinical trial execution phase (UH3) of investigator-initiated neurologic research. A formal clinical trial is required for all applications.
How to apply
Application links
Required documents
- SF-424 (R&R)
- Project Narrative (Research Strategy)
- Specific Aims
- Significance and Innovation
- Approach
- Budget Justification
- Budget (SF-424 R&R)
- Biographical Sketches (NIH format, 4-5 pages each)
- Resources and Environment
- Letters of Support/Commitment
- Clinical Trial Protocol (or draft)
- IRB Approval or proof of pending review
- Data Safety Monitoring Plan
- Statistical Analysis Plan
Program contact
- 👤 National Institutes of Health
- 📧 grantsinfo@nih.gov
- 📞 301-402-2541
Funding track record
Recent awards under CFDA 93.853 from the last 3 years — real organizations that won funding through this same program.
Top 10 Largest Recent Awards
-
$82,511,281
-
$67,362,785
-
$62,646,087
-
$56,144,651
-
$45,268,737
-
$40,959,789
-
$35,655,349
-
$35,655,116
-
$35,335,145
-
$34,183,297
Top States by Funding
- MA 6 awards $186.5M
- CA 4 awards $129.9M
- OH 4 awards $112.5M
- FL 3 awards $100.3M
- MN 2 awards $99.4M
Source: USAspending.gov — federal spending transparency. Data covers last 3 years.
Funding history
Annual funding for this program — Federal obligations (CFDA 93.853). How funding has trended year over year.
| 2024 | $2,362,835,459 | |
| 2025 | $2,345,500,401 |
FAQ
Who can apply for this grant?
Academic institutions, medical centers, and hospitals with clinical research capacity and NIH regulatory compliance infrastructure. Individual researchers must be affiliated with eligible institutions.
Is a clinical trial required?
Yes. Applications must involve a prospective clinical trial in neurology or neurological disorders. This is a mandatory requirement.
What is the timeline for this award?
The UG3 phase provides planning funding (typically 1-2 years). Successful applications transition to UH3 for clinical trial execution (typically 3-4 years).
How competitive is this mechanism?
Very competitive. These awards fund rigorous clinical trials with significant scientific impact. Strong preliminary data and experienced research teams are essential.
What funding range should I expect?
Typical UG3 awards range from $100K-$300K annually. UH3 awards typically range from $300K-$1M+ depending on trial scope and complexity.
💡 Tips for applicants
- Start with strong preliminary data demonstrating trial feasibility and clinical importance in your neurologic indication.
- Build a multidisciplinary team including neurologists, biostatisticians, data managers, and clinical research coordinators.
- Address patient recruitment and retention explicitly. Detail how you will enroll and retain participants in your trial.
- Develop a realistic budget justifying all personnel and trial costs. Include adequate funds for regulatory compliance and clinical oversight.
- Write a compelling scientific narrative showing how results will advance the neurology field and patient care.
⚠️ Common mistakes
Insufficient preliminary data or feasibility evidence. Many applications fail because they lack strong evidence that the trial is achievable.
Inadequate detail on recruitment, retention, and participant safety protocols. Reviewers need clear plans for managing clinical trial operations and participant protection.
Weak or inexperienced research team missing key roles like biostatisticians or clinical coordinators. Clinical trials require specialized expertise.
Similar grants
- OPEN 27-0343-10 FFY27 Local Agency General Non-Enforcement — Illinois Department of Transportation
- ROLLING Annual Agency Threshold Application Applicants for Funding Start Here — Texas City of Austin - Austin Public Health
- CLOSED Virginia’s Black Indigenous and People of Color (BIPOC) Grant – FY26 — Virginia The Virginia Department of Historic Resources
- ROLLING RTAP Grant Program (Rolling) — Virginia Department of Rail and Public Transportation
- ROLLING Rail Industrial Access Grant (RIA) — Virginia Department of Rail and Public Transportation