Improving Chronic Conditions Through Inexpensive Interventions
Can you apply?
This grant is for researchers and organizations working to develop and test low-cost interventions for chronic health conditions. NIH typically supports academic institutions, research hospitals, and nonprofits with strong research capacity. The program funds projects that demonstrate feasibility and potential scalability of affordable treatment approaches. Applicants must have institutional infrastructure to conduct clinical or translational research and comply with federal research regulations.
Key dates
- Feb 23, 2026 Applications open
- Sep 25, 2026 Application deadline in 116 days
- Jul 1, 2027 Award announced
- Jul 1, 2027 Project start
This grant is for researchers and organizations working to develop and test low-cost interventions for chronic health conditions. NIH typically supports academic institutions, research hospitals, and nonprofits with strong research capacity. The program funds projects that demonstrate feasibility and potential scalability of affordable treatment approaches. Applicants must have institutional infrastructure to conduct clinical or translational research and comply with federal research regulations.
Program description
The National Institute on Aging (NIA) intends to publish a Notice of Funding Opportunity (NOFO) to invite applications to create a national consortium of researchers, clinicians, and electronic health record (EHR) vendors. The consortium will conduct research to evaluate clinical effectiveness impacts of different care approaches on whole-person outcomes and quality metrics. This NOFO is intended to support collaborative research efforts for scaling EHR interventions. The consortium will identify proven primary care interventions for older adults with complex medical issues including multiple chronic conditions—ranging from preventive services and chronic care coordination to deprescribing and goal-setting—then integrate these into interoperable, AI- and machine learning-enhanced platforms to support both individual patient care and population health management. Applicants and their partners will build and deploy user-centered dashboards, validate their effectiveness in real-world settings, and address implementation barriers (people, processes, technology). Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO intends to utilize the U24 activity code. Investigators with expertise and insights into this area of aging research are encouraged to begin to consider applying for this new NOFO.
Who can apply
Eligible applicants
- 501(c)(3) Public Charity
- City / Municipal Government
- County Government
- Nonprofits
- Private University
- Public Authority
- Public K-12 School
- Public University
- Small Business (SBA-defined)
- Special District
- Tribal Nation
- Tribal Organization
Demographic focus
Details
This grant is for researchers and organizations working to develop and test low-cost interventions for chronic health conditions. NIH typically supports academic institutions, research hospitals, and nonprofits with strong research capacity. The program funds projects that demonstrate feasibility and potential scalability of affordable treatment approaches. Applicants must have institutional infrastructure to conduct clinical or translational research and comply with federal research regulations.
How to apply
Application links
Key dates & requirements
Required documents
- SF-424 (R&R) Application Form
- Project Narrative
- Budget and Budget Justification
- Biosketches (key personnel)
- Letters of Support/Collaboration
- Facilities and Equipment Description
- Research Strategy (Specific Aims, Significance, Innovation, Approach)
Program contact
- 👤 NIA Scientific Contact
- 📧 NIA-NOFO-Scientific@nih.gov
- 📞 Please contact via e-mail and include the announcement number in the subject line.
Funding track record
Recent awards under CFDA 93.866 from the last 3 years — real organizations that won funding through this same program.
Top 10 Largest Recent Awards
-
$463,372,200
-
$172,327,224
-
$115,145,694
-
$99,649,073
-
$93,275,174
-
$78,657,309
-
$75,825,492
-
$75,398,895
-
$70,985,470
-
$64,812,576
Top States by Funding
- MI 2 awards $511.9M
- CA 8 awards $511.1M
- MO 8 awards $437.0M
- IN 4 awards $303.9M
- PA 6 awards $298.0M
Source: USAspending.gov — federal spending transparency. Data covers last 3 years.
Funding history
Annual funding for this program — Federal obligations (CFDA 93.866). How funding has trended year over year.
| 2024 | $3,746,886,731 | |
| 2025 | $3,777,464,644 | |
| 2026 est. | $261,814,471 |
FAQ
Who can apply for this grant?
Research institutions, universities, and nonprofits with research capacity typically qualify. Individual researchers usually need institutional affiliation. Check the Notice of Funding Opportunity for specific eligibility requirements.
What does this grant fund?
Projects developing affordable interventions for chronic diseases like diabetes, hypertension, or arthritis. Funding supports research design, pilot studies, and feasibility testing.
What is the typical funding range?
NIH research grants vary widely. This program type typically ranges from $100K to $500K+ annually. Check the NOFO for specific limits.
How competitive is this program?
NIH is highly competitive. Success rates typically range from 10-25%. Strong preliminary data and a clear innovation angle are essential.
When is the deadline?
Application opening date is February 23, 2026. Check NIH grants.gov for specific submission deadlines and any rolling submission windows.
💡 Tips for applicants
- Focus on cost reduction and real-world applicability. Show why your intervention is affordable compared to standard care.
- Build strong preliminary data before applying. Even small pilot studies strengthen your application significantly.
- Clearly define your target population and how inexpensive interventions will reach underserved communities.
- Partner with clinical sites or community health organizations that can help implement and test your approach.
- Address sustainability and dissemination early. Show how your intervention can scale if successful.
⚠️ Common mistakes
Weak preliminary data or feasibility unclear. Applicants often underestimate cost analysis requirements; be specific about savings and implementation barriers. Vague dissemination plans hurt competitiveness; show how results reach practitioners and patients.
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