Forecast to Publish a Funding Opportunity Announcement for Integrative Neuroscience Initiative on Alcoholism (INIA) Consortia (U01 Clinical Trial Optional)
🏛 National Institutes of Health (HHS-NIH11)
✓ Free, no account · Source: Grants.gov · Last verified Jul 15, 2026
Can you apply?
This grant is for funded research consortia studying alcohol use disorder and brain-body interactions through collaborative neuroscience research. Eligible applicants are academic institutions, research hospitals, and nonprofit organizations with research capacity that can lead multisite consortia projects. Multiple collaborating sites must participate, with administrative/resource cores and individual U01 projects. The research must focus on neurobiological mechanisms of excessive alcohol drinking and translation to prevention/intervention strategies.
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Key dates
- May 6, 2025 Applications open
- May 1, 2026 Application deadline
- Feb 1, 2027 Award announced
- Feb 1, 2027 Project start
Program description
The purpose is to renew the NIAAA Integrative Neuroscience Initiative on Alcoholism (INIA). The INIA renewal will support two collaborative research consortia through an open competition to study brain-body homeostatic dysregulation that promotes and perpetuates excessive alcohol drinking and related Alcohol Use Disorder (AUD) phenotypes. We encourage hypothesis-centered research on interactions between alcohol and other relevant causal influences. Focus on trajectories from initial alcohol exposure to the development of pathological drinking by some individuals will identify translatable markers and mechanisms to support future prevention and intervention efforts that reduce the chronic conditions associated with alcohol misuse including but not limited to AUD. To promote innovation, investigators will adapt advanced tools and technologies from the BRAIN Initiative, NIH Common Fund, and other sources to examine brain structure and function at multiple spatial and temporal scales, from microcircuitry to whole brain networks, and reveal peripheral influences on brain function underlying excessive alcohol drinking. To promote rigor and reproducibility, a focus on standardization of neurofunctional measures and replication will be instituted across both consortia. In the context of the initiative, integration occurs with: (1) projects across multiple participating sites addressing objectives around a central hypothesis, (2) knowledge of actions and interactions at multiple biological scales of analysis, (3) shared resources and standardized experimental protocols, and (4) cross-species translation. The initiative renewal will support two collaborating multisite consortia though cooperative agreement mechanisms, each comprised of administrative and resource cores, and U01s for individual research projects. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the U01activity code. Investigators with expertise and insights into this area of integrative neuroscience are encouraged to begin to consider applying for this new NOFO.
Who can apply
Eligible applicants
How to apply
Application links
Key dates & requirements
Required documents
- SF-424 (R&D) Application Form
- Project Narrative (research aims and methods)
- Budget and Budget Narrative
- Biosketch(es)
- Letters of Support (multisite collaborators)
- Resource Sharing Plans
- Consortium Agreement(s)
Program contact
- 👤 Mark Egli
- 📧 mark.egli@nih.gov
- 📞 (301) 594-6392
Funding track record
Recent awards under CFDA 93.273 from the last 3 years — real organizations that won funding through this same program.
Top 10 Largest Recent Awards
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$125,900,663
-
$34,675,742
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$34,469,501
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$33,261,336
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$32,897,567
-
$31,652,514
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$30,394,602
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$29,223,384
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$29,195,978
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$29,168,993
Top States by Funding
- CA 15 awards $242.3M
- NY 3 awards $162.6M
- OR 7 awards $96.3M
- NC 4 awards $67.1M
- IN 3 awards $57.4M
Source: USAspending.gov — federal spending transparency. Data covers last 3 years.
Funding history
Annual funding for this program — Federal obligations (CFDA 93.273). How funding has trended year over year.
| 2024 | $430,377,419 | |
| 2025 | $429,906,735 | |
| 2026 est. | $12,401,560 |
FAQ
Who can apply for this grant?
Research institutions, universities, hospitals, and nonprofit organizations with demonstrated neuroscience research capacity. Consortia must include multiple participating sites collaborating on shared objectives.
What is the deadline?
The deadline is May 1, 2026. This is a fixed single deadline with advance notice to allow time for collaboration development.
What types of research are supported?
Hypothesis-centered research on brain-body interactions in alcohol use disorder. Studies of mechanisms from initial alcohol exposure to pathological drinking, using advanced neuroscience tools.
How competitive is this grant?
Highly competitive. NIH funding supports two consortia through this program. Strong preliminary data and multisite collaboration networks are essential for success.
What funding levels should I expect?
Total pool is $10,000,000 distributed across two consortia with multiple research projects and cores. Individual project budgets vary within consortium structure.
💡 Tips for applicants
- Begin building multisite collaborations immediately; consortia structure is essential and takes time to develop effectively.
- Focus on integrating research across biological scales, from microcircuitry to whole brain networks, to align with initiative goals.
- Incorporate standardized neurofunctional measures and replication protocols to demonstrate rigor and reproducibility.
- Adapt tools from BRAIN Initiative and NIH Common Fund resources to strengthen methodological innovation in your approach.
- Ensure clear translation pathways from bench research to future prevention and intervention applications in AUD treatment.
⚠️ Common mistakes
Submitting single-site projects instead of true multisite consortia with integrated objectives. Lacking clear translational focus from mechanistic findings to prevention or intervention targets. Inadequate detail on cross-species translation strategies or standardized measurement protocols.
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