Forecast to Publish a Funding Opportunity Announcement for Copy of Integrative Neuroscience Initiative on Alcoholism (INIA) Consortia Research Resource (U24) (Clinical Trial Optional)
🏛 National Institutes of Health (HHS-NIH11)
✓ Free, no account · Source: Grants.gov · Last verified Jul 15, 2026
Can you apply?
This grant is for research institutions and consortia that can lead multisite collaborative projects studying alcohol use disorder and related neuroscience. Eligible applicants must have institutional capacity to manage cooperative agreements and coordinate multiple research sites. The initiative requires hypothesis-centered, translational research on brain-body interactions related to excessive alcohol drinking. Applicants should have expertise in neuroscience, behavioral science, or related disciplines, and capability to standardize protocols across participating sites.
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Key dates
- May 5, 2025 Applications open
- May 1, 2026 Application deadline
- Feb 1, 2027 Award announced
- Feb 1, 2027 Project start
Program description
The purpose is to renew the NIAAA Integrative Neuroscience Initiative on Alcoholism (INIA). The INIA renewal will support two collaborative research consortia through an open competition to study brain-body homeostatic dysregulation that promotes and perpetuates excessive alcohol drinking and related Alcohol Use Disorder (AUD) phenotypes. We encourage hypothesis-centered research on interactions between alcohol and other relevant causal influences. Focus on trajectories from initial alcohol exposure to the development of pathological drinking by some individuals will identify translatable markers and mechanisms to support future prevention and intervention efforts that reduce the chronic conditions associated with alcohol misuse including but not limited to AUD. To promote innovation, investigators will adapt advanced tools and technologies from the BRAIN Initiative, NIH Common Fund, and other sources to examine brain structure and function at multiple spatial and temporal scales, from microcircuitry to whole brain networks, and reveal peripheral influences on brain function underlying excessive alcohol drinking. To promote rigor and reproducibility, a focus on standardization of neurofunctional measures and replication will be instituted across both consortia. In the context of the initiative, integration occurs with: (1) projects across multiple participating sites addressing objectives around a central hypothesis, (2) knowledge of actions and interactions at multiple biological scales of analysis, (3) shared resources and standardized experimental protocols, and (4) cross-species translation. The initiative renewal will support two collaborating multisite consortia though cooperative agreement mechanisms, each comprised of administrative and resource cores, and U01s for individual research projects. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the U24 activity code. Investigators with expertise and insights into this area of integrative neuroscience are encouraged to begin to consider applying for this new NOFO.
Who can apply
Eligible applicants
How to apply
Application links
Key dates & requirements
Required documents
- SF-424 (Application for Federal Assistance)
- Project Narrative and Research Strategy
- Budget and Budget Justification
- Organizational and institutional documentation
- Biosketch(es) of key personnel
- NIH-specific forms (e.g., Cover Letter)
Program contact
- 👤 Mark Egli
- 📧 mark.egli@nih.gov
- 📞 301-594-6392
Funding track record
Recent awards under CFDA 93.273 from the last 3 years — real organizations that won funding through this same program.
Top 10 Largest Recent Awards
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$125,900,663
-
$34,675,742
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$34,469,501
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$33,261,336
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$32,897,567
-
$31,652,514
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$30,394,602
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$29,223,384
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$29,195,978
-
$29,168,993
Top States by Funding
- CA 15 awards $242.3M
- NY 3 awards $162.6M
- OR 7 awards $96.3M
- NC 4 awards $67.1M
- IN 3 awards $57.4M
Source: USAspending.gov — federal spending transparency. Data covers last 3 years.
Funding history
Annual funding for this program — Federal obligations (CFDA 93.273). How funding has trended year over year.
| 2024 | $430,377,419 | |
| 2025 | $429,906,735 | |
| 2026 est. | $12,401,560 |
FAQ
Who can apply for this grant?
Research institutions with capacity to lead multisite consortia. Individual investigators are not eligible; applications are for administrative cores and resource cores of collaborative consortia.
What is the deadline?
The fixed deadline is May 1, 2026. This is currently a Notice of Funding Opportunity (NOFO) — formal applications are not yet being solicited.
What types of projects are funded?
Research examining brain-body interactions in alcohol use disorder. Projects must be hypothesis-centered and translational, with focus on trajectories from initial alcohol exposure to pathological drinking.
How competitive is this funding?
Very competitive. This is a federal NIH grant with limited awards. Strong preliminary data, established collaborations, and rigorous methodology are essential.
What is the funding amount?
The total pool is $700,000 across two consortia awards. Individual project and core budgets will vary by scope.
💡 Tips for applicants
- Begin building your multisite consortium now. The NOFO is not yet open, but establishing collaborations early is critical for a strong application.
- Focus on hypothesis-centered science that bridges multiple biological scales. Use tools from the BRAIN Initiative and NIH Common Fund to strengthen innovation.
- Plan for standardized protocols and replication across all participating sites. Consistency in neurofunctional measures is a key initiative goal.
- Emphasize translational impact. Show how your research will identify markers and mechanisms for future prevention and intervention in alcohol use disorder.
- Include expertise in rigor and reproducibility. This initiative prioritizes robust experimental design and cross-species translation of findings.
⚠️ Common mistakes
- Proposing single-site research instead of true multisite consortia with shared resources and integrated projects. - Lacking hypothesis-centered framework or failing to clearly articulate brain-body homeostatic dysregulation mechanisms. - Ignoring standardization requirements; inconsistent protocols across sites reduce funding likelihood.
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