Optimal Treatment Strategies for use of Anti-Obesity Medications (AOMs) in Children and Adolescents Research Coordinating Center (U24 Clinical Trial Not Allowed)
🏛 National Institutes of Health (HHS-NIH11)
✓ Free, no account · Source: Grants.gov · Last verified Jul 15, 2026
Can you apply?
This grant is for research institutions and medical centers seeking to establish a Research Coordinating Center (RCC) for a clinical consortium studying anti-obesity medications in youth. Eligible applicants typically include universities, research hospitals, and academic medical centers with NIH experience and capacity to manage multisite clinical studies. The RCC will coordinate testing of treatment strategies across multiple clinical centers to evaluate optimal timing, dosing, and adjunct therapies for anti-obesity medications in children and adolescents. Strong preference for organizations with proven ability to conduct rigorous clinical trials, manage centralized data systems, and coordinate complex consortium activities.
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Key dates
- Jun 8, 2026 Applications open
- Oct 9, 2026 Application deadline in 85 days
- Jul 1, 2027 Award announced
- Jul 1, 2027 Project start
Program description
This Notice of Funding Opportunity (NOFO) invites applications for a Research Coordinating Center (RCC) for a consortium of clinical centers that will test anti-obesity medication (AOM) treatment strategies for youth with obesity to maximize benefits and minimize risks of AOM use. Priority areas include testing strategies to determine optimal developmental stage for AOM initiation, rate and amount of weight loss, AOM class, dose, frequency, and duration, and content and intensity of adjunct lifestyle therapies that may be imperative to ensure normal psychological and physical development and to potentially avoid lifelong dependence on AOMs. Investigators should also evaluate potential predictors of response/ nonresponse to various treatment strategies under evaluation.
The consortium may conduct independent or multicenter trials but will collaborate on the development of protocols, use of common measures and data elements, use of a central laboratory and standardized procedures to collect data and biospecimens, and data analyses and manuscripts. The RCC will lead, manage, and harmonize efforts for the Consortium including 1) providing management and administrative support; 2) providing leadership and expertise on statistical design and analysis, 3) providing research coordination with a central laboratory, harmonizing data collection methods and common data elements, data management and data analyses for Consortium studies; and 4) fostering research collaborations.
Who can apply
Eligible applicants
- 501(c)(3) Public Charity
- City / Municipal Government
- County Government
- Private University
- Public Authority
- Public K-12 School
- Public University
- Small Business (SBA-defined)
- Special District
- State Government
- Tribal Nation
- Tribal Organization
Demographic focus
How to apply
Application links
Key dates & requirements
Required documents
- SF-424 (Application for Federal Assistance)
- Project Narrative and Specific Aims
- Research Strategy
- Management Plan (for RCC coordination and consortium governance)
- Budget and Budget Narrative
- Biographical Sketches
- NIH Assurances and Compliance
- Letters of Support from Consortium Clinical Centers
Program contact
- 👤 Stavroula K. Osganian, MD, ScD, MPH
- 📧 voula.osganian@nih.gov
- 📞 (301) 827-6939
Funding track record
Recent awards under CFDA 93.847 from the last 3 years — real organizations that won funding through this same program.
Top 10 Largest Recent Awards
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$438,527,853
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$200,221,259
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$152,979,352
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$112,529,392
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$66,521,567
-
$45,186,589
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$39,699,167
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$37,490,770
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$34,242,949
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$31,624,784
Top States by Funding
- WA 3 awards $492.3M
- NC 4 awards $291.6M
- FL 2 awards $184.1M
- MA 6 awards $168.4M
- PA 6 awards $168.1M
Source: USAspending.gov — federal spending transparency. Data covers last 3 years.
Funding history
Annual funding for this program — Federal obligations (CFDA 93.847). How funding has trended year over year.
| 2024 | $1,971,472,000 | |
| 2025 | $2,043,166,000 | |
| 2026 est. | $111,289,000 |
FAQ
What is the primary role of the Research Coordinating Center?
The RCC manages the consortium, provides statistical expertise, operates a central laboratory, harmonizes data collection across sites, and supports data analyses and publications.
Who can serve as the lead institution for the RCC?
Research institutions and medical centers with demonstrated NIH grant management experience and capacity to coordinate multisite clinical studies are eligible. Specific details appear in the full NOFO.
What is the deadline for applications?
The fixed deadline is December 1, 2026. Check the NOFO for submission time details.
Are multi-site clinical trials required?
The RCC will coordinate independent or multicenter trials within the consortium. All participating sites must use common protocols, data elements, and procedures.
What supporting infrastructure must the RCC provide?
The RCC must establish a central laboratory, develop standardized data collection procedures, maintain common data elements, and provide ongoing data management and coordination.
💡 Tips for applicants
- Demonstrate your institution's prior success managing large NIH cooperative agreements and multisite research consortia.
- Develop a detailed plan for the central laboratory, including specific data collection methods, common data elements, and quality assurance protocols.
- Include a strong statistical and data management team with expertise in pediatric clinical trials and complex data harmonization.
- Clearly describe how you'll foster collaboration across independent clinical centers and manage consortium governance.
- Address expertise in anti-obesity medications, pediatric obesity research, and developmental considerations for youth treatment.
⚠️ Common mistakes
Underestimating the operational complexity of coordinating multiple clinical centers and managing a central laboratory. Failing to demonstrate sufficient prior experience managing large NIH cooperative agreements. Providing vague plans for data harmonization and common data element standardization across consortium sites.
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