Data Coordinating Center for Multi-Site Investigator-Initiated Clinical Trials (Collaborative U24 Clinical Trial Required)
🏛 National Institutes of Health (HHS-NIH11)
✓ Free, no account · Source: Grants.gov · Last verified Sep 4, 2026
Can you apply?
This grant is for National Institutes of Health-funded Data Coordinating Centers supporting investigator-initiated multi-site clinical trials. Organizations must have capacity for data management, biostatistical support, and project coordination for clinical research. Eligible applicants include universities, research institutions, nonprofit organizations, and foreign entities (without foreign subawards). Applications require a parallel Clinical Coordinating Center application submitted on the same deadline.
Clinical trials must be relevant to NHLBI research priorities and meet NIH clinical trial definitions. Trials testing therapeutic, behavioral, or prevention strategies are supported. Innovative trial designs like platform, adaptive, and Bayesian designs are encouraged. Comparative effectiveness, pragmatic, and implementation research trials are also eligible.
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Program description
This Notice of Funding Opportunity (NOFO) supports applications for a collaborating Data Coordinating Center (DCC) for investigator-initiated multi-site clinical trials including efficacy, comparative effectiveness, pragmatic and/or implementation research clinical trials. Trials using innovative designs such as platform trials, adaptive, and Bayesian designs are encouraged. These trials may include ones that test different therapeutic, behavioral, and/or prevention strategies. Trials for which this NOFO applies must be relevant to the research mission of the NHLBI and meet the NIH definition of a clinical trial (see NOT-OD-15-015). For additional information about the mission, strategic vision, and research priorities of the NHLBI, applicants are encouraged to consult the NHLBI website.This NOFO will utilize a milestone-driven cooperative agreement mechanism of award and runs in parallel with a companion NOFO (PAR-27-012) for a collaborating Clinical Coordinating Center (CCC). The objective of the DCC application is to present a comprehensive plan to provide overall project coordination, administration, data management, and biostatistical support for the clinical trial proposed in the collaborating CCC application. The application should also describe its approaches to collaborate with the CCC on implementation of the clinical trial community engagement plan. Both a DCC application and a collaborating CCC application must be submitted on the same application due date for consideration by NHLBI. Applicants are strongly encouraged to contact the appropriate Scientific/Research contact prior to submitting an application.
Who can apply
Eligible applicants
How to apply
Application links
Key dates & requirements
Required documents
- SF-424 (R&R) form
- Project Narrative (DCC-specific proposal)
- Budget and Budget Justification
- Biographical sketches of key personnel
- Letters of collaboration with proposed CCC
- Data management and biostatistics plan
- Community engagement collaboration plan
Program contact
- 👤 National Institutes of Health
- 📧 NHLBIDCVSClinical@mail.nih.gov
- 📞 301-402-2541
Funding track record
Recent awards under CFDA 93.838 from the last 3 years — real organizations that won funding through this same program.
Top 10 Largest Recent Awards
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$64,183,283
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$53,344,199
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$43,989,024
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$38,428,037
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$34,243,478
-
$27,859,190
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$26,861,834
-
$26,624,924
-
$26,063,829
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$25,493,029
Top States by Funding
- MA 14 awards $249.4M
- CA 16 awards $207.8M
- CO 8 awards $139.0M
- IL 7 awards $108.5M
- NC 4 awards $95.8M
Source: USAspending.gov — federal spending transparency. Data covers last 3 years.
Funding history
Annual funding for this program — Federal obligations (CFDA 93.838). How funding has trended year over year.
| 2024 | $760,925,134 | |
| 2025 | $789,408,855 |
FAQ
Who can apply for this DCC grant?
Universities, research institutions, nonprofits, and other organizations with data management expertise can apply. Foreign entities are eligible, but foreign subawards/subcontracts are not permitted after May 1, 2025.
Is a Clinical Coordinating Center application required?
Yes, a parallel CCC application must be submitted by the same deadline for your DCC application to be considered by NHLBI.
What does the DCC provide to the clinical trial?
The DCC provides data management, biostatistical support, project coordination, administration, and collaboration on community engagement implementation.
What types of clinical trials are eligible?
Efficacy, comparative effectiveness, pragmatic, and implementation research trials are supported. Innovative designs like platform, adaptive, and Bayesian trials are encouraged.
When is the application deadline?
The fixed deadline is November 2, 2028. No rolling applications or extensions are available for this funding opportunity.
💡 Tips for applicants
- Contact the NHLBI scientific officer early to align your DCC plan with the companion CCC application and trial design.
- Demonstrate strong data management infrastructure and biostatistical capacity relevant to multi-site trials.
- Include a clear collaboration plan with the Clinical Coordinating Center on community engagement and implementation.
- Emphasize alignment with NHLBI research mission and priorities; review NHLBI strategic vision before writing.
- Allow sufficient time for coordinated submission: both DCC and CCC applications must arrive by the same deadline.
⚠️ Common mistakes
Submitting without a companion CCC application. Both applications must be submitted together. Proposing a DCC that duplicates CCC functions instead of complementing them. Failing to clearly describe data management and biostatistical expertise relevant to multi-site trials.
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