Clinical Coordinating Center for NCCIH Multi-Site Investigator-Initiated Clinical Trials of Natural Products (Collaborative UG3/UH3 Clinical Trial Required)
🏛 National Institutes of Health (HHS-NIH11)
✓ Free, no account · Source: Grants.gov · Last verified Jul 14, 2026
Can you apply?
This grant is for researchers at eligible U.S. institutions planning multi-site Phase III and beyond clinical trials of natural products. Applicants must propose a Clinical Coordinating Center to manage the trial. A corresponding Data Coordinating Center application must be submitted simultaneously.
Eligible applicants include academic institutions, HBCUs, Hispanic-serving institutions, tribal colleges, faith-based and community-based organizations, and federal agencies. U.S. territories and possessions are eligible. Foreign organizations cannot apply, though U.S. organizations may have foreign components.
The grant supports natural product research in areas of high NCCIH priority. Examples include botanicals, probiotics, dietary supplements, and standardized nutritional compounds (omega-3 fatty acids, polyphenols, anthocyanidins). Applicants must demonstrate compelling preliminary evidence and describe recruitment, retention, and dissemination strategies.
Not the right fit? Find grants for your organization in 5 questions →
Program description
This Notice of Funding Opportunity (NOFO) encourages cooperative agreement applications for investigator-initiated, multi-site, clinical trials (Phase III and beyond) to study the effects of natural products (i.e. botanicals, probiotics, and products marketed as dietary supplements) in NCCIH designated areas of high research priority. For this NOFO, natural products include promising nutritional regimens that standardize the amount of a specific naturally occurring nutritional compound (e.g., omega-3 fatty acids, anthocyanidins, or polyphenols) and have compelling preliminary evidence. Applicants should describe plans for a Clinical Coordinating Center to develop and implement the proposed multi-site clinical trial. The objective of the Clinical Coordinating Center application is to provide the scientific rationale and a comprehensive scientific and operational plan for the clinical trial. Clinical Coordinating Center applications are expected to describe plans for project management, participant recruitment and retention strategies, performance milestones, scientific conduct, and dissemination of results. Clinical Coordinating Center applications submitted under this NOFO will utilize a two-phase, milestone-driven, cooperative agreement (UG3/UH3) funding mechanism.
In addition, an accompanying Data Coordinating Center application, submitted under PAR-24-125, proposing a data analysis and data management plan for the clinical project is required. Both a Clinical Coordinating Center application and a corresponding Data Coordinating Center (DCC) application need to be submitted simultaneously for consideration by NCCIH. For additional information about the mission, strategic vision, and research priorities of the NCCIH, applicants are encouraged to consult the NCCIH website: (https://nccih.nih.gov/about/plans).
Who can apply
Eligible applicants
- 501(c)(3) Public Charity
- City / Municipal Government
- Colleges (all higher ed)
- County Government
- HBCU
- HSI (Hispanic Serving Institution)
- Nonprofits
- Private University
- Public Authority
- Public K-12 School
- Public University
- Small Business (SBA-defined)
- Special District
- State Government
- Tribal Nation
- Tribal Organization
How to apply
Application links
Key dates & requirements
Required documents
- SF-424 (R&R) Application Form
- Project Narrative (Research Strategy section)
- Budget and Budget Justification
- Biographical Sketches (Key Personnel)
- Facilities and Other Resources
- Letters of Support (Clinical sites, DCC partner)
- NCCIH-specific forms per NOFO
Program contact
- 👤 National Institutes of Health
- 📧 grantsinfo@nih.gov
- 📞 301-402-2541
Funding track record
Recent awards under CFDA 93.213 from the last 3 years — real organizations that won funding through this same program.
Top 10 Largest Recent Awards
-
$22,367,527
-
$21,646,919
-
$19,236,131
-
$17,730,528
-
$15,036,701
-
$14,473,882
-
$12,748,932
-
$11,956,053
-
$11,225,697
-
$10,919,780
Top States by Funding
- CA 13 awards $83.5M
- MA 13 awards $80.2M
- WA 8 awards $69.9M
- NC 7 awards $53.8M
- NY 6 awards $40.0M
Source: USAspending.gov — federal spending transparency. Data covers last 3 years.
Funding history
Annual funding for this program — Federal obligations (CFDA 93.213). How funding has trended year over year.
| 2024 | $240,178,154 | |
| 2025 | $232,899,116 | |
| 2026 est. | $2,655,626 |
FAQ
Can for-profit companies apply?
No, this is limited to eligible institutions and organizations. Eligible applicants include nonprofits, academic institutions, and government agencies.
Do I need a Data Coordinating Center partner?
Yes, a corresponding Data Coordinating Center application must be submitted simultaneously with the Clinical Coordinating Center application.
What types of natural products are eligible?
Botanicals, probiotics, dietary supplements, and standardized nutritional compounds with compelling preliminary evidence are eligible.
Is this a single-phase award or multi-phase?
This uses a two-phase UG3/UH3 cooperative agreement structure with milestone-driven funding.
Can foreign institutions apply?
No, but U.S. organizations with foreign components or foreign collaborators may be allowed.
💡 Tips for applicants
- Start with NCCIH priority areas. Consult the NCCIH website to identify high-priority natural product research topics before developing your proposal.
- Develop DCC partnership early. Identify and coordinate with a Data Coordinating Center partner before submission, as both applications must be submitted simultaneously.
- Emphasize preliminary data. Include compelling evidence supporting your natural product's efficacy and justify the move to Phase III testing.
- Plan recruitment carefully. Describe specific, realistic strategies for recruiting and retaining participants across multiple clinical sites.
- Detail the Clinical Coordinating Center structure. Clearly outline project management, performance milestones, and oversight mechanisms for the multi-site trial.
⚠️ Common mistakes
Applications lack compelling preliminary evidence or do not justify advancement to Phase III. Applicants fail to submit matching Data Coordinating Center applications simultaneously, making them ineligible. Proposals underestimate recruitment and retention challenges or provide vague participant engagement strategies.
Similar grants
- OPEN NCCIH Natural Product Early Phase Clinical Trial Award (R33 Clinical Trial Required) — National Institutes of Health
- CLOSED Clinical Coordinating Center for NCCIH Multi-Site Investigator-Initiated Clinical Trials of Mind and Body Interventions (Collaborative UG3/UH3 Clinical Trial Required) — National Institutes of Health
- OPEN Clinical Coordinating Center for Multi-Site Investigator-Initiated Clinical Trials (Collaborative UG3/UH3 Clinical Trial Required) — National Institutes of Health
- OPEN NCCIH Natural Product Early Phase Clinical Trial Phased Innovation Award (R61/R33 Clinical Trial Required) — National Institutes of Health
- CLOSED Natural Product Multi-Site Clinical Trial Data Coordinating Center (Collaborative U24 Clinical Trial Required) — National Institutes of Health