Clinical Coordinating Center for NCCIH Multi-Site Investigator-Initiated Clinical Trials of Mind and Body Interventions (Collaborative UG3/UH3 Clinical Trial Required)
Can you apply?
This grant is for institutions planning multi-site clinical trials of mind and body interventions in complementary and integrative health. Eligible applicants include universities, research institutions, HBCUs, tribal colleges, faith-based and community organizations, and federal agencies. The applicant must serve as the Clinical Coordinating Center (CCC) and submit a corresponding Data Coordinating Center (DCC) application simultaneously. Foreign organizations and non-U.S. components of U.S. organizations are not eligible.
This grant is for institutions planning multi-site clinical trials of mind and body interventions in complementary and integrative health. Eligible applicants include universities, research institutions, HBCUs, tribal colleges, faith-based and community organizations, and federal agencies. The applicant must serve as the Clinical Coordinating Center (CCC) and submit a corresponding Data Coordinating Center (DCC) application simultaneously. Foreign organizations and non-U.S. components of U.S. organizations are not eligible.
Program description
This notice of funding opportunity (NOFO) encourages applications for investigator-initiated multi site clinical trials (e.g., efficacy, effectiveness, or pragmatic trials) to study the effects of complementary and integrative health approaches with physical and/or psychological therapeutic inputs (often called mind and body interventions), and/or multicomponent interventions that include physical, psychological, and/or nutritional approaches in NCCIH- designated areas of high research priority. Clinical Coordinating Centers (CCC) should develop and implement the proposed fully powered multi-site clinical trial (Phase III and beyond). The objective of a CCC application is to present the scientific rationale and a comprehensive scientific and operational plan for the clinical trial. CCC applications are expected to describe plans for project management, participant recruitment and retention strategies, performance milestones, scientific conduct, and dissemination of results. CCC applications submitted under this NOFO will utilize a two-phase, milestone-driven cooperative agreement (UG3/UH3) funding mechanism.
In addition, an accompanying Data Coordinating Center (DCC) application (U24), submitted under PAR-24-087 proposing a data analysis and data management plan for the clinical project is required. Both a CCC application and a corresponding DCC application need to be submitted simultaneously for consideration by NCCIH. For additional information about the mission, strategic vision, and research priorities of NCCIH, applicants are encouraged to consult the NCCIH website: (https://nccih.nih.gov/about/plans).
Applicants are encouraged to contact the appropriate Scientific/Research contact for the area of science for which they are planning to develop an application prior to submitting to this NOFO.
Who can apply
Eligible applicants
- 501(c)(3) Public Charity
- City / Municipal Government
- County Government
- Faith-based Organization
- HBCU
- Nonprofits
- Private University
- Public Authority
- Public K-12 School
- Public University
- Small Business (SBA-defined)
- Special District
- State Government
- Tribal Nation
- Tribal Organization
Details
This grant is for institutions planning multi-site clinical trials of mind and body interventions in complementary and integrative health. Eligible applicants include universities, research institutions, HBCUs, tribal colleges, faith-based and community organizations, and federal agencies. The applicant must serve as the Clinical Coordinating Center (CCC) and submit a corresponding Data Coordinating Center (DCC) application simultaneously. Foreign organizations and non-U.S. components of U.S. organizations are not eligible.
How to apply
Application links
Required documents
- SF-424 (R&R) Application for Federal Assistance
- Project Narrative describing scientific rationale and comprehensive operational plan
- Budget narrative and justification
- Data Coordinating Center (DCC) application (submitted simultaneously under PAR-24-087)
- Performance milestones and timeline
- Participant recruitment and retention strategies
Program contact
- 👤 National Institutes of Health
- 📧 grantsinfo@nih.gov
- 📞 301-402-2541
Funding track record
Recent awards under CFDA 93.213 from the last 3 years — real organizations that won funding through this same program.
Top 10 Largest Recent Awards
-
$22,367,527
-
$21,646,919
-
$19,236,131
-
$17,730,528
-
$15,036,701
-
$14,473,882
-
$12,748,932
-
$11,956,053
-
$11,225,697
-
$10,919,780
Top States by Funding
- MA 13 awards $80.2M
- CA 12 awards $79.7M
- WA 8 awards $69.9M
- NC 7 awards $52.3M
- NY 6 awards $40.0M
Source: USAspending.gov — federal spending transparency. Data covers last 3 years.
Funding history
Annual funding for this program — Federal obligations (CFDA 93.213). How funding has trended year over year.
| 2024 | $240,178,154 | |
| 2025 | $232,899,116 | |
| 2026 est. | $2,655,626 |
FAQ
Who can apply for this grant?
Universities, research institutions, HBCUs, tribal colleges, faith-based organizations, community organizations, and eligible federal agencies can apply. Foreign entities are not eligible.
What is required besides the CCC application?
A corresponding Data Coordinating Center (DCC) application must be submitted at the same time under a separate PAR.
What types of interventions does this fund?
Mind and body interventions including physical, psychological, and/or nutritional approaches in areas of high research priority for NCCIH.
How is this grant structured?
It uses a two-phase, milestone-driven cooperative agreement (UG3/UH3) mechanism with Phase I planning and Phase II implementation.
When is the deadline?
The deadline is July 14, 2026, and this is a fixed deadline (not rolling).
💡 Tips for applicants
- Contact the appropriate NCCIH Scientific Research contact before applying. They can clarify which research priority areas fit your trial.
- Ensure your DCC application aligns perfectly with your CCC application since both are reviewed together.
- Develop detailed project management, recruitment, retention, and dissemination plans early in proposal writing.
- Review NCCIH's strategic vision and research priorities on their website to align your clinical trial.
- Budget for a fully powered Phase III clinical trial with multi-site infrastructure and coordination capacity.
⚠️ Common mistakes
Submitting only a CCC application without a simultaneous DCC application will result in rejection. Proposing interventions outside NCCIH priority areas reduces competitiveness. Underestimating coordination complexity and data management needs across multiple sites weakens applications.
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