Continuation of the Exceptional Longevity Data Management and Coordinating Center (EL DMCC) (U24 Clinical Trial Not Allowed)
🏛 National Institutes of Health (HHS-NIH11)
✓ Free, no account · Source: Grants.gov · Last verified Oct 20, 2026
Can you apply?
This grant is for data management and coordinating centers focused on longevity research. Eligible applicants include research institutions, universities, and nonprofit organizations with capacity to operate a coordinating center. The center must manage multi-cohort datasets, provide data harmonization, and coordinate collaborative research activities.
Geographic scope is national. Applicants must have expertise in data management, statistical analysis, and AI/ML infrastructure. The award supports continued operations of an established coordinating center serving NIA's longevity research portfolio.
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Key dates
- Sep 24, 2026 Applications open
- May 8, 2027 Application deadline in 199 days
- Apr 30, 2028 Award announced
- Apr 30, 2028 Project start
Program description
The National Institute on Aging (NIA) intends to publish a Notice of Funding Opportunity (NOFO) to support the continued operation and expansion of the Exceptional Longevity Data Management and Coordinating Center (EL DMCC) through a single U24 cooperative agreement award. The NOFO will be open to all eligible applicants.
Established in 2022, the EL DMCC serves as the central hub for NIA’s human longevity translational research portfolio, integrating data and activities across studies to maximize the value of deeply phenotyped cohorts and associated genomic and multi-omics datasets.
The DMCC currently plays a critical role in enabling cross-cohort analyses, coordinating collaborative research, and advancing shared data resources. Core functions include data harmonization and integration; development and implementation of common data standards; provision of statistical, computational, and artificial intelligence and machine learning (AI/ML) infrastructure and tools; coordination of cross-project collaborations; and managing shared data systems, including data storage, access, and platform operations.
The DMCC also develops and maintains the ELITE (Exceptional Longevity Translational Resources) Portal, which provides secure access to harmonized datasets, analytical tools, and cloud-based computational workspaces. The DMCC supports controlled access to EL data and use of these resources by the research community and maintains ongoing efforts to ensure the Portal is interoperable with the NIA Alzheimer’s Disease Knowledge Portal and other data resources of the National Institutes of Health, consistent with FAIR (Findable, Accessible, Interoperable, Reusable) data principles.
Through the NOFO, the Coordinating Center will be expected to build on and expand these core functions by:
- Enhancing integration of increasingly large and diverse datasets across cohorts and species
- Expanding statistical, computational, and AI/ML capabilities and associated infrastructure
- Developing and refining methods and standards for multi-omics data harmonization and integrative analyses
- Coordinating and supporting collaborative research across NIA-funded projects
- Developing and disseminating translational resources, including target nomination and prioritization resources, curated target knowledgebases, and inventories of candidate therapeutic targets
- Advancing the ELITE Portal, including improvements in data organization, search, visualization, interoperability, and cloud-based analytical environments
- Strengthening community engagement through training, workshops, and collaborative activities
Applications are not being solicited at this time. This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects.
Who can apply
Eligible applicants
How to apply
Application links
Key dates & requirements
Required documents
- SF-424 (Application for Federal Assistance)
- Project Narrative/Research Strategy
- Budget and Budget Justification
- Organizational Capacity and Infrastructure Documentation
- Letters of Support from NIA-Funded Projects
- Data Management and AI/ML Technical Plans
- ELITE Portal Enhancement Plan
Program contact
- 👤 NIA Scientific Contact
- 📧 NIA-NOFO-Scientific@nih.gov
- 📞 Please contact via e-mail
Funding track record
Recent awards under CFDA 93.866 from the last 3 years — real organizations that won funding through this same program.
Top 10 Largest Recent Awards
-
$463,372,200
-
$199,819,363
-
$148,130,300
-
$113,990,692
-
$109,670,101
-
$102,150,671
-
$89,954,729
-
$85,658,817
-
$81,449,732
-
$80,730,785
Top States by Funding
- CA 10 awards $673.7M
- MI 2 awards $528.1M
- MO 8 awards $476.4M
- IN 4 awards $328.1M
- PA 6 awards $323.7M
Source: USAspending.gov — federal spending transparency. Data covers last 3 years.
Funding history
Annual funding for this program — Federal obligations (CFDA 93.866). How funding has trended year over year.
| 2024 | $3,746,886,731 | |
| 2025 | $3,777,464,644 | |
| 2026 est. | $261,814,471 |
FAQ
Who is eligible to apply for this grant?
Research institutions, universities, and nonprofits with capacity to operate a coordinating center are eligible. The applicant must demonstrate expertise in data management, bioinformatics, and research coordination.
What is the deadline and application timeline?
The deadline is May 8, 2027. This is a fixed deadline for a single cooperative agreement award. Applications are not being solicited at this time; the notice allows time to develop collaborations.
What activities and infrastructure will be funded?
Funding supports data harmonization, statistical and AI/ML tools, cross-cohort collaboration coordination, and management of the ELITE Portal. The center provides secure access to datasets and cloud-based computational resources.
Is cost-sharing required?
No, cost-sharing is not required for this grant. Full project costs are eligible for funding.
What is the typical funding range and project duration?
Award amounts are not specified in the notice. Project duration and renewal terms should be clarified when the full NOFO is published.
💡 Tips for applicants
- Emphasize your institution's track record managing large, multi-cohort datasets. Highlight past successes with data harmonization and integration.
- Detail your AI/ML and computational infrastructure capabilities. Show how you will scale systems to handle increasingly large and diverse datasets.
- Describe specific collaborations and partnerships with NIA-funded research projects. Name key collaborators and explain how you will coordinate their work.
- Propose concrete enhancements to data access, portal functionality, and analytical tools. Connect improvements to researcher needs and FAIR data principles.
- Demonstrate commitment to community engagement through training, workshops, and transparent data governance. Show how you will support diverse researchers in using the Portal.
⚠️ Common mistakes
Failing to demonstrate sustained capacity to manage large, complex multi-omics datasets across multiple cohorts. Proposing generic data management functions rather than integrated, transformative infrastructure that advances longevity research. Underestimating the scope of coordination, training, and community engagement required to support a national research portfolio.
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