Undiagnosed Diseases Network (UDN) Clinical and Data Coordinating Center
🏛 National Institutes of Health (HHS-NIH11)
✓ Free, no account · Source: Grants.gov · Last verified Oct 18, 2026
Can you apply?
This grant is for organizations that can serve as a Clinical and Data Coordinating Center for the Undiagnosed Diseases Network. Eligible applicants include research institutions, medical centers, and universities with established infrastructure and expertise in clinical research coordination and data management.
Applicants must demonstrate capacity for patient recruitment, regulatory compliance, data sharing systems, and informatics capabilities. The coordinating center will provide operational oversight for network activities including participant support and systematic case re-evaluation.
Organizations must show readiness to collaborate with clinical networks, NIH programs, patient advocacy groups, and other stakeholders. Minimal start-up time is expected following award.
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Key dates
- Sep 10, 2026 Applications open
- May 25, 2027 Application deadline in 218 days
- May 25, 2027 Award announced
- Apr 25, 2028 Project start
Program description
NINDS intends to support a new phase of the Undiagnosed Diseases Network (UDN) to advance diagnosis for individuals with previously undiagnosed diseases and undiagnosed diseases research. This phase would emphasize participant and family engagement, provider engagement, use of NIH and non-NIH resources, education, community engagement, research innovation and discovery, and broader implementation of advanced diagnostic approaches.
The Network is expected to include a Clinical and Data Coordinating Center (CDCC), clinical Networks of Diagnostic Excellence, the NIH Undiagnosed Diseases Program (UDP), a Diagnostic Research Innovation Center, individuals with lived experience, patient advocacy organizations, NIH, and other stakeholders.
NINDS anticipates supporting a CDCC to provide operational oversight and coordination for network activities including recruitment, participant support (e.g., patient navigation services, referring diagnosed participants to potential therapeutic options), protocol and regulatory management, data sharing, innovation in analytics, support for the systematic re-evaluation of unsolved UDN cases, collaboration, training, implementation science research to facilitate the transfer of successful UDN diagnostic approaches into mainstream medical care, and quality oversight and performance monitoring of the network. Applicants should demonstrate the infrastructure, staffing, governance, regulatory capacity, informatics systems, operational readiness, and stakeholder partnerships necessary to assume CDCC responsibilities with minimal start-up time following award.
Applications are not being solicited at this time. This Forecast is being published to provide potential applicants time to plan, develop meaningful collaborations, and responsive projects.
Who can apply
Eligible applicants
How to apply
Application links
Key dates & requirements
Required documents
- SF-424 (federal form)
- Project Narrative
- Budget and Budget Justification
- Organizational Chart and Staffing Plan
- Letters of Support from Partner Organizations
- Data Management and Informatics Plan
- Regulatory and Compliance Documentation
- Biographical Sketches of Key Personnel
Program contact
- 👤 UDN Program Staff
- 📧 UDNProgramStaff@ninds.nih.gov
- 📞 Please contact via e-mail.
Funding track record
Recent awards under CFDA 93.853 from the last 3 years — real organizations that won funding through this same program.
Top 10 Largest Recent Awards
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$56,262,774
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$45,083,283
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$43,730,658
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$38,186,781
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$37,769,493
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$35,655,349
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$35,655,116
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$34,183,297
-
$32,294,153
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$32,164,022
Top States by Funding
- MA 7 awards $186.3M
- CA 6 awards $163.5M
- FL 4 awards $121.0M
- OH 4 awards $112.5M
- NY 3 awards $91.7M
Source: USAspending.gov — federal spending transparency. Data covers last 3 years.
Funding history
Annual funding for this program — Federal obligations (CFDA 93.853). How funding has trended year over year.
| 2024 | $2,362,835,459 | |
| 2025 | $2,345,500,401 |
FAQ
When is the application deadline?
The deadline is May 25, 2027. This grant is currently in forecast phase; applications are not yet being solicited.
What are the main responsibilities of the Clinical and Data Coordinating Center?
The CDCC provides operational oversight, manages recruitment and participant support, handles data sharing and analytics, and ensures quality monitoring and regulatory compliance across the network.
Do I need to have existing diagnostic expertise?
Your institution should demonstrate established infrastructure for clinical research coordination, data management, and informatics systems. Prior experience with large research networks is beneficial.
Is cost-sharing required?
No cost-sharing is required for this cooperative agreement.
What type of organization can apply?
Research institutions, academic medical centers, and universities with infrastructure for complex clinical research coordination and data management are typical applicants.
💡 Tips for applicants
- Start building partnerships now with clinical networks, NIH programs, and patient advocacy organizations. These collaborations strengthen competitiveness and demonstrate stakeholder buy-in.
- Emphasize your existing infrastructure for data management, regulatory compliance, and participant support services. Highlight systems that are already operational to minimize start-up time.
- Focus on your capacity for innovation in diagnostics and analytics. Show how you'll implement advanced diagnostic approaches and share lessons across the network.
- Develop a clear governance structure and decision-making process. Demonstrate how you'll coordinate multiple clinical sites and manage complex network operations.
- Plan your staffing model carefully. Identify key roles in patient navigation, data management, regulatory oversight, and provide realistic timelines for recruitment.
⚠️ Common mistakes
Applications underestimate the operational complexity of coordinating a multi-site network. Provide detailed plans for managing diverse stakeholders and sites.
Weak informatics and data-sharing infrastructure descriptions hurt competitiveness. Show concrete examples of existing systems and technical capacity.
Insufficient emphasis on participant engagement and family partnership strategies. Demonstrate genuine commitment to involving individuals with lived experience in network design and operations.
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