Somatic Mosaicism across Human Tissues (SMaHT) Program: National Somatic Mosaicism Commons Data Analysis & Organizational Center (UM1 Clinical Trial Not Allowed)
🏛 National Institutes of Health (HHS-NIH11)
✓ Free, no account · Source: Grants.gov · Last verified Oct 19, 2026
Can you apply?
This grant is for established research institutions and organizations seeking to create a data analysis and organizational center for the Somatic Mosaicism across Human Tissues (SMaHT) Network. Eligible applicants typically include universities, medical centers, and research organizations with experience managing large-scale genomic datasets and providing bioinformatics infrastructure. The center will manage multi-omic somatic mutation data, develop analysis tools, and provide training and outreach to the research and clinical communities.
Applicants must demonstrate capacity to build and maintain a data portal, variant catalog, and visualization tools. Experience with data management, bioinformatics platforms, and network governance is essential. The award is not available for clinical trials.
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Key dates
- Sep 14, 2026 Applications open
- Jul 1, 2027 Application deadline in 254 days
- May 1, 2028 Award announced
- May 1, 2028 Project start
Program description
The purpose of the Somatic Mosaicism across Human Tissues (SMaHT) Network is to advance the discovery of biological processes and disease mechanisms mediated by somatic mutations in human tissues. Since 2023, the program has generated multi-omic somatic mutation datasets from a standardized set of human tissues spanning all three germ layers. Building on the Stage 1 foundation, the NIH intends to issue a Notice of Funding Opportunity (NOFO) seeking support for Stage 2 through the National Somatic Mosaicism Commons Data Analysis & Organizational Center. The National Somatic Mosaicism Commons Data Analysis & Organizational Center combines data management and analysis with network governance, coordination, outreach, and training. The Center will develop tools and platforms that allow SMaHT Network members and the wider clinical and research communities to investigate and use these complex datasets.
The center will be responsible for managing network data and providing access to data analysis tools developed in the program. This will include building the SMaHT data portal, Variant Catalog, variant browser, visualization tools, and analysis-ready releases. The center will also conduct outreach to clinical and research communities and provide training in SMaHT resources.
Who can apply
Eligible applicants
How to apply
Application links
Key dates & requirements
Required documents
- NIH Form SF-424 (R&R)
- Project Narrative
- Budget and Budget Justification
- Biographical Sketches (Key Personnel)
- Facilities and Resources
- Letters of Support (from SMaHT Network members or research communities)
- Data Management and Sharing Plan
- References Cited
Program contact
- 👤 SMaHT Program
- 📧 smaht@od.nih.gov
- 📞 Please contact via e-mail.
Funding track record
Recent awards under CFDA 93.310 from the last 3 years — real organizations that won funding through this same program.
Top 10 Largest Recent Awards
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$383,462,829
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$198,364,987
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$190,396,050
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$179,737,926
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$169,422,678
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$148,383,140
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$143,679,156
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$115,739,255
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$108,778,286
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$90,799,903
Top States by Funding
- NC 4 awards $446.4M
- WA 1 awards $383.5M
- MD 2 awards $317.8M
- NY 3 awards $207.3M
- CA 1 awards $198.4M
Source: USAspending.gov — federal spending transparency. Data covers last 3 years.
Funding history
Annual funding for this program — Federal obligations (CFDA 93.310). How funding has trended year over year.
| 2024 | $1,174,839,078 | |
| 2025 | $1,062,277,534 | |
| 2026 est. | $28,100,048 |
FAQ
Who is eligible to apply for this grant?
Established research institutions, universities, and medical centers with demonstrated experience in large-scale genomic data management and bioinformatics infrastructure. Organizations must show capacity to manage complex multi-omic datasets and develop analysis tools.
What is the primary focus of the funded center?
The center manages SMaHT Network data, develops analysis tools and data portal, and provides training and outreach to research and clinical communities. It serves as the organizational hub for the somatic mosaicism research network.
What data management and infrastructure must the center provide?
The center must build and maintain a data portal, variant catalog, variant browser, visualization tools, and prepare analysis-ready data releases. It should enable SMaHT members and broader communities to access and analyze datasets.
What experience is most important for a competitive application?
Strong track record managing large genomic datasets, developing bioinformatics platforms, and supporting research communities. Experience with data governance and training programs is also valuable.
When is the deadline for this funding opportunity?
The deadline is July 1, 2027. This is a fixed deadline, so applications must be submitted by that date.
💡 Tips for applicants
- Emphasize your institution's existing genomic data infrastructure and ability to scale it for multi-omic datasets. Show specific examples of platforms you have built and maintained.
- Detail your experience with data governance, network coordination, and community outreach in research contexts. Highlight any existing relationships with clinical or research communities.
- Include letters of support from potential SMaHT Network members and research communities that would use the center's resources. Demonstrate demand for your proposed tools and services.
- Plan for sustainability beyond the initial award period. Show how the center will maintain data access and tools long-term through diverse funding or institutional commitment.
- Propose user-friendly interfaces and visualization tools that serve both computational researchers and clinicians. Include preliminary designs or prototypes if possible.
⚠️ Common mistakes
Underestimating the scope of data management and bioinformatics infrastructure required. Many applicants fail to adequately plan for scaling systems to handle large multi-omic datasets.
Insufficient emphasis on network governance and community engagement. This is a coordination center, not just a data repository—applications must address how the center will support and coordinate the entire SMaHT Network.
Weak or absent sustainability plans. Reviewers expect clear strategies for long-term funding and institutional support beyond the initial cooperative agreement period.
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