Single Source for Chronic Kidney Diseases of UnceRtain Etiology (CKDu) in Agricultural Communities (CURE) Research Consortium – Data Coordinating Center (DCC)
Can you apply?
This grant is for eligible organizations to serve as the Data Coordinating Center for a consortium studying Chronic Kidney Disease of Uncertain Etiology (CKDu) in agricultural communities.
Applicants must demonstrate capacity to provide data management, analysis, and overall project management for a multi-site research consortium. Organizations should have experience with epidemiologic data coordination and multi-institutional collaboration.
The project supports research into environmental and genetic risk factors for CKDu in rural populations. Work includes managing data from field sites, analyzing kidney disease progression, and identifying potential therapeutic targets and public health interventions.
Key dates
- Feb 5, 2026 Applications open
- Jul 1, 2026 Application deadline in 30 days
- Jan 1, 2027 Award announced
- Feb 1, 2027 Project start
This grant is for eligible organizations to serve as the Data Coordinating Center for a consortium studying Chronic Kidney Disease of Uncertain Etiology (CKDu) in agricultural communities.
Applicants must demonstrate capacity to provide data management, analysis, and overall project management for a multi-site research consortium. Organizations should have experience with epidemiologic data coordination and multi-institutional collaboration.
The project supports research into environmental and genetic risk factors for CKDu in rural populations. Work includes managing data from field sites, analyzing kidney disease progression, and identifying potential therapeutic targets and public health interventions.
Program description
The purpose of this funding opportunity is to advance the NIH mission by supporting the continuation of the Consortium to Study Chronic Kidney Disease of UnceRtain Etiology (CKDu) in Agricultural Communities (CURE).
Chronic Kidney Disease of Uncertain Etiology (CKDu) causes kidney failure in rural areas of many Low and Middle Income Countries, resulting in a large death toll among the young working age population. Environmental factors are suspected to be causative, but family and geographic clustering add consideration of unrecognized genetic susceptibility. The risk factors identified in other countries are encountered by U.S. patients, so this research will offer valuable insights into the development and progression of tubulointerstitial renal diseases, with broad implications for understanding kidney health and disease in the U.S.
NIDDK, NIEHS, and FIC have jointly funded a consortium that includes Field Epidemiology Sites, a Renal and Environmental Science Core, and a Data Coordinating Center to find causes and potential interventions for CKDu since 2021. This NOFO requests a renewal application for the Data Coordinating Center that will provide data management and analysis, as well as overall project management for the Consortium. Consortium members will continue to collaborate to maximize scientific opportunities and enable discovery science to understand the etiologies of CKDu, the exposures that initiate and affect progression of tubulointerstitial kidney disease, potential therapeutic targets, and future opportunities for public health interventions. The CURE Consortium will serve as a resource for ancillary studies.
This is a forecast for a single source Notice of Funding Opportunity (NOFO) that will invite application(s) from eligible organizations to apply. Application(s) will be peer-reviewed and only funded if meritorious.
Who can apply
Eligible applicants
- 501(c)(3) Public Charity
- County Government
- Nonprofits
- Private University
- Public Authority
- Public University
- Small Business (SBA-defined)
- State Government
- Tribal Nation
- Tribal Organization
Details
This grant is for eligible organizations to serve as the Data Coordinating Center for a consortium studying Chronic Kidney Disease of Uncertain Etiology (CKDu) in agricultural communities.
Applicants must demonstrate capacity to provide data management, analysis, and overall project management for a multi-site research consortium. Organizations should have experience with epidemiologic data coordination and multi-institutional collaboration.
The project supports research into environmental and genetic risk factors for CKDu in rural populations. Work includes managing data from field sites, analyzing kidney disease progression, and identifying potential therapeutic targets and public health interventions.
How to apply
Application links
Key dates & requirements
Required documents
- SF-424 (R&R) Application for Federal Assistance
- Project Narrative (Research Strategy)
- Budget and Budget Narrative
- Biographical Sketches (Key Personnel)
- Consortium/Contractual Agreements
- Current Data Management Plans
Program contact
- 👤 Division of Kidney, Urologic, and Hematologic Diseases
- 📧 NIDDK_KUH@nih.gov
- 📞 301.594.6417
Funding track record
Recent awards under CFDA 93.847 from the last 3 years — real organizations that won funding through this same program.
Top 10 Largest Recent Awards
-
$152,979,352
-
$112,529,392
-
$66,521,567
-
$45,186,589
-
$37,867,943
-
$37,490,770
-
$34,242,949
-
$31,624,784
-
$31,124,496
-
$31,065,476
Top States by Funding
- FL 2 awards $184.1M
- MA 6 awards $165.7M
- PA 6 awards $165.0M
- NY 4 awards $143.8M
- MD 2 awards $143.4M
Source: USAspending.gov — federal spending transparency. Data covers last 3 years.
Funding history
Annual funding for this program — Federal obligations (CFDA 93.847). How funding has trended year over year.
| 2024 | $1,971,472,000 | |
| 2025 | $2,043,166,000 | |
| 2026 est. | $111,289,000 |
FAQ
Who can apply for this grant?
Eligible organizations with expertise in data management, epidemiologic research coordination, and multi-site project management. The specific eligible organization types will be detailed in the final NOFO.
What is the deadline for applications?
The application deadline is July 1, 2026. This is a fixed deadline for the Data Coordinating Center renewal.
What activities does this funding support?
Data management and analysis, project coordination for consortium sites, managing epidemiologic data, and supporting discovery science on kidney disease etiology.
How competitive is this funding?
This is a single-source award intended to continue an existing consortium. The current DCC must demonstrate strong past performance and scientific merit in renewal applications.
What is the funding amount available?
The total funding pool is $1,750,000. The specific award amount to the selected Data Coordinating Center will depend on the scope and budget proposed.
💡 Tips for applicants
- Emphasize your organization's experience managing large, multi-site epidemiologic datasets and coordinating complex research consortia.
- Highlight your track record with the current CURE Consortium if continuing as DCC, or similar consortial research if new applicant.
- Detail your data management infrastructure, including security, quality control, and analysis capabilities for kidney disease research.
- Plan for continuity: explain how you will ensure seamless transition and maintain data integrity across consortium sites.
- Address the scientific priorities outlined by NIDDK, NIEHS, and FIC in your coordination and analysis plans.
⚠️ Common mistakes
Underestimating the scope of multi-site coordination required. Failing to demonstrate prior experience with large epidemiologic consortia. Proposing inadequate data security and quality control protocols for sensitive research data.
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