Single Source Competition: Continuation of the Cardiovascular Repository for Type 1 Diabetes (CaRe-T1D) – Resource Center (U24 Clinical Trial Not Allowed)
🏛 National Institutes of Health (HHS-NIH11)
✓ Free, no account · Source: Grants.gov · Last verified Jul 16, 2026
Can you apply?
This grant is for research institutions and organizations studying cardiovascular disease in type 1 diabetes using the CARE-T1D biorepository resources. Eligible applicants must be able to serve as the resource center managing cardiovascular tissue collection, storage, and analysis from organ donors. The continuation project supports hypothesis-driven research using multi-omics and molecular approaches to understand cardiac disease pathogenesis in type 1 diabetes.
This is a single-source competition, meaning only pre-selected organizations may apply. Applicants must demonstrate capacity to maintain and expand the data repository while coordinating consortium activities. The work focuses on collecting and analyzing tissue samples and sharing findings with the research community.
Not the right fit? Find grants for your organization in 5 questions →
Key dates
- Jun 4, 2026 Applications open
- Sep 30, 2026 Application deadline in 75 days
- Feb 1, 2027 Award announced
- Feb 1, 2027 Project start
Program description
The NIDDK and NHLBI seek to advance their mission by a continuation of the Cardiovascular Repository for Type 1 Diabetes (CARE-T1D) consortium. The CARE-T1D biorepository was established in 2020 through RFA-DK-21-010 and has successfully collected, stored and analyzed cardiovascular tissue (hearts, aortas, carotid arteries and kidneys) from organ donors with type 1 diabetes, type 2 diabetes and without diabetes. A consortium was formed in 2024 through RFA-DK-23-021 to carry out research focused on hypothesis driven research on pathogenesis of cardiac disease in T1D using multi-omics and molecular approaches using the CARE-T1D resources. The goal of this funding opportunity is to continue the CARE-T1D resource center and its work in collecting, analyzing and sharing cardiovascular tissue from organ donors with type 1 diabetes, type 2 diabetes and without diabetes; maintaining and expanding the data repository with results from the consortium resources; and coordinating consortium activities. This research seeks to improve our understanding of cardiovascular disease in type 1 diabetes and the differences with type 2 diabetes and no diabetes to develop therapies to treat this major cause of mortality for people with type 1 diabetes.
This is a Forecast for a Single Source competition that will invite application(s) from eligible organization(s) to apply. Please see Eligibility Section for additional information. In accordance with NIH standard peer-review processes, the application(s) will be peer-reviewed, and only meritorious application(s) will be considered for funding.
Who can apply
Eligible applicants
How to apply
Application links
Key dates & requirements
Required documents
- SF-424 (R&R) Application Form
- Project Narrative/Scientific Abstract
- Detailed Budget and Budget Narrative
- Biographical Sketches (key personnel)
- Data Management and Sharing Plan
- Biosafety/Institutional Review Board documentation
- Letters of Support from consortium members
Program contact
- 👤 Teresa L. Z. Jones, M.D.
- 📧 teresa.jones@nih.gov
- 📞 301-435-2996
Funding track record
Recent awards under CFDA 93.837 from the last 3 years — real organizations that won funding through this same program.
Top 10 Largest Recent Awards
-
$238,898,122
-
$137,304,316
-
$117,298,604
-
$100,148,361
-
$90,428,339
-
$88,304,328
-
$83,989,552
-
$83,865,426
-
$64,483,725
-
$64,342,479
Top States by Funding
- MD 6 awards $470.1M
- NY 9 awards $442.1M
- MA 4 awards $301.0M
- CA 6 awards $201.9M
- WI 3 awards $147.1M
Source: USAspending.gov — federal spending transparency. Data covers last 3 years.
Funding history
Annual funding for this program — Federal obligations (CFDA 93.837). How funding has trended year over year.
| 2024 | $1,654,455,334 | |
| 2025 | $1,690,039,433 |
FAQ
Who is eligible to apply for this grant?
This is a single-source competition. Only organizations pre-identified by NIH are invited to apply. Contact the program officer for eligibility clarification.
What is the deadline?
The application deadline is July 1, 2026. This is a fixed deadline, not rolling.
What activities are supported?
Funding supports collecting, storing, and analyzing cardiovascular tissue; maintaining and expanding the data repository; and coordinating consortium research activities.
How much funding is available?
The total funding pool is $2,000,000. Individual award amounts have not been specified in available materials.
Is cost-sharing required?
No cost-sharing is required for this grant. All eligible costs can be covered by the federal award.
💡 Tips for applicants
- Contact the NIH program officer early to understand single-source competition requirements and your organization's specific role.
- Emphasize existing capacity to manage biorepository operations, including tissue storage, handling protocols, and quality control procedures.
- Highlight your consortium coordination experience and ability to facilitate multi-institutional research collaboration.
- Include detailed plans for expanding the data repository and maintaining high-quality tissue samples and associated data.
- Demonstrate expertise in multi-omics and molecular analysis methods relevant to cardiovascular disease research in diabetes.
⚠️ Common mistakes
Failing to clarify single-source eligibility status before investing application effort. Underestimating the operational complexity of managing a multi-institutional biorepository and tissue resources. Proposing research activities outside the scope of resource management and consortium coordination.
Similar grants
- OPEN Continuation of the Cardiovascular Repository for-Type 1 Diabetes (CARE-T1D) Consortium U01 (Open Competition)- Research (U01, Clinical Trial Not Allowed) — National Institutes of Health
- CLOSED Rigor and Reproducibility for Biomarkers in Type 1 Diabetes Clinical Research — National Institutes of Health
- CLOSED Single Source for the Continuation of the Epidemiology of Diabetes Interventions and Complications (EDIC) Study Research Center (Collaborative U01 Clinical Trial Not Allowed) — National Institutes of Health
- OPEN NHLBI TOPMed: Omics Phenotypes of Heart, Lung, and Blood Disorders (X01 – Clinical Trial Not Allowed) — National Institutes of Health
- OPEN Ancillary Studies to Ongoing Clinical Projects (RP1 Clinical Trial Not Allowed) — National Institutes of Health