Continuation of the Cardiovascular Repository for-Type 1 Diabetes (CARE-T1D) Consortium U01 (Open Competition)- Research (U01, Clinical Trial Not Allowed)
🏛 National Institutes of Health (HHS-NIH11)
✓ Free, no account · Source: Grants.gov · Last verified Jul 16, 2026
Can you apply?
This grant is for researchers and institutions studying cardiovascular health in people with type 1 diabetes. Academic institutions, research hospitals, and nonprofit research organizations can apply. The NIH funds basic, translational, and clinical research. Applicants must have the capacity to conduct high-quality research and contribute to a collaborative consortium. International collaborations may be permitted with institutional verification.
This is a continuation grant for an established research consortium. New institutions may apply to join the consortium or lead new research tracks. Researchers need faculty appointments or equivalent research positions. PhD-level expertise is typically required.
Not the right fit? Find grants for your organization in 5 questions →
Key dates
- Jun 4, 2026 Applications open
- Mar 1, 2027 Award announced
- Mar 1, 2027 Project start
- Mar 10, 2027 Application deadline in 236 days
Program description
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), in collaboration with the National Heart, Lung, and Blood Institute, intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for discovery and mechanistic research to advance the understanding of cardiovascular disease in type 1 diabetes through a continuation of the CARE-T1D consortium. A consortium of six research teams was formed in 2024 through RFA-DK-23-021 to conduct hypothesis-driven research on the pathogenesis of cardiac disease in T1D using multi-omics and molecular approaches, leveraging the CARE-T1D resources. This NOFO will utilize the U mechanism activity code U01 mechanism for the investigative teams. Investigators with expertise and insights into this area of cardiovascular disease in T1D are encouraged to consider applying for this new NOFO. In addition, collaborative investigations combining expertise in T2D, atherosclerosis, Inflammation, and cutting-edge omics techniques will be encouraged, and these investigators should also consider applying for this NOFO.
Who can apply
Eligible applicants
How to apply
Application links
Key dates & requirements
Required documents
- SF-424 (R&R) form
- Project Narrative (specific aims, background, significance, innovation, approach)
- Budget and budget justification
- Biographical sketches of key personnel
- Letters of support from consortium partners
- Facilities and resources documentation
- Data management and sharing plan
Program contact
- 👤 Chandima Nishadi De Abrew Rajapakse, PhD, MHS
- 📧 Chandima.rajapakse@nih.gov
- 📞 240-429-5197
Funding track record
Recent awards under CFDA 93.838 from the last 3 years — real organizations that won funding through this same program.
Top 10 Largest Recent Awards
-
$64,183,283
-
$53,344,199
-
$43,989,024
-
$38,428,037
-
$34,243,478
-
$27,859,190
-
$26,861,834
-
$26,624,924
-
$26,063,829
-
$25,153,102
Top States by Funding
- MA 14 awards $246.9M
- CA 15 awards $199.1M
- CO 8 awards $139.0M
- IL 7 awards $107.8M
- NC 4 awards $95.8M
Source: USAspending.gov — federal spending transparency. Data covers last 3 years.
Funding history
Annual funding for this program — Federal obligations (CFDA 93.838). How funding has trended year over year.
| 2024 | $760,925,134 | |
| 2025 | $789,408,855 |
FAQ
Who is eligible to apply for this NIH U01 grant?
Research institutions, universities, and medical centers with strong research infrastructure. PIs must hold faculty or equivalent research positions.
What types of research are supported?
Cardiovascular disease research in type 1 diabetes populations. Both mechanistic and clinical studies are funded.
What is the typical funding range?
NIH U01 grants typically range $250,000-$500,000+ per year. Exact amounts vary by project scope and consortium structure.
How competitive is this grant?
Very competitive. Expect strong preliminary data, established track record, and clear innovation. Consortium experience is highly valued.
When is the application deadline?
Check NIH.gov for the specific open competition deadline. Typically NIH has deadlines multiple times per year.
💡 Tips for applicants
- Build strong preliminary data showing cardiovascular outcomes in type 1 diabetes cohorts.
- Demonstrate clear integration with the existing CARE-T1D consortium structure and goals.
- Include detailed multi-year research plan with specific, measurable cardiovascular endpoints.
- Assemble a team with complementary expertise in cardiology, endocrinology, and biostatistics.
- Address how your work advances the consortium's capacity for long-term cardiovascular follow-up studies.
⚠️ Common mistakes
Weak preliminary data or lack of published evidence in cardiovascular-diabetes research. Vague consortium collaboration plans or failure to align with existing CARE-T1D objectives. Underestimating complexity of longitudinal cardiovascular outcome tracking in type 1 diabetes populations.
Similar grants
- OPEN Single Source Competition: Continuation of the Cardiovascular Repository for Type 1 Diabetes (CaRe-T1D) – Resource Center (U24 Clinical Trial Not Allowed) — National Institutes of Health
- CLOSED Single Source for the Continuation of the Epidemiology of Diabetes Interventions and Complications (EDIC) Study Research Center (Collaborative U01 Clinical Trial Not Allowed) — National Institutes of Health
- CLOSED Single Source for the Continuation of the Physiology of the Weight Reduced State (POWERS) Study (U01- Clinical Trials Required) — National Institutes of Health
- OPEN Continuation of the Collaborative Islet Transplantation Registry (U01 Clinical Trial Not allowed) — National Institutes of Health
- OPEN Diabetes Research Centers (P30 Clinical Trial Optional) — National Institutes of Health