Single Source Competition for Continuation of Understanding and Targeting the Pathophysiology of Youth-Onset Type 2 Diabetes Clinical Centers (U01 Clinical Trial Not Allowed)
🏛 National Institutes of Health (HHS-NIH11)
✓ Free, no account · Source: Grants.gov · Last verified Sep 4, 2026
Can you apply?
This grant is for continuation funding of an established multi-center clinical research consortium studying youth-onset type 2 diabetes. Eligible applicants are the institutions currently participating in the DISCOVERY Study clinical sites and the designated Biostatistics Research Center. This is a single-source award, meaning only the current grant holder(s) may apply. The grant supports completion of ongoing longitudinal follow-up, data management, statistical analysis, and inter-site coordination activities.
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Key dates
- Aug 4, 2026 Applications open
- Mar 10, 2027 Application deadline in 186 days
- Nov 1, 2027 Award announced
- Dec 1, 2027 Project start
Program description
The DISCOVERY of Risk Factors for Type 2 Diabetes in Youth Study is a multi-center longitudinal consortium conducted across 19 clinical sites to identify risk factors and biological mechanisms driving progression to youth-onset type 2 diabetes. The study is actively recruiting and following early pubertal youth at high risk for the disease with longitudinal follow-up currently underway. The current Biostatistics Research Center (BRC) serves as the consortium’s central coordinating center, managing protocol implementation, data management, quality assurance, statistical design and analysis, and inter-site and consortium-wide coordination. The BRC has established the robust infrastructure and standardized processes required to support the study and preserve the integrity of the longitudinal dataset.
The purpose of this single-source solicitation is to support completion of the scientific objectives of the ongoing DISCOVERY clinical consortium.
Who can apply
Eligible applicants
Demographic focus
How to apply
Application links
Key dates & requirements
Required documents
- SF-424 Application Cover Sheet
- Project Narrative (Research Plan)
- Budget and Budget Justification
- Biographical Sketches of Key Personnel
- Protection of Human Subjects documentation
- Data Management Plan
- Multi-site coordination documentation
- Letters of Support from participating clinical sites
Program contact
- 👤 Division of Diabetes, Endocrinology and Metabolic Diseases
- 📧 NIDDK_DEM@nih.gov
- 📞 NIDDK_DEM@nih.gov
Funding track record
Recent awards under CFDA 93.847 from the last 3 years — real organizations that won funding through this same program.
Top 10 Largest Recent Awards
-
$438,527,853
-
$200,221,259
-
$152,979,352
-
$112,529,392
-
$82,457,560
-
$48,585,892
-
$45,186,589
-
$37,490,770
-
$34,242,949
-
$32,783,433
Top States by Funding
- WA 4 awards $513.7M
- NC 4 awards $291.6M
- NY 5 awards $184.3M
- FL 2 awards $184.1M
- PA 6 awards $176.9M
Source: USAspending.gov — federal spending transparency. Data covers last 3 years.
Funding history
Annual funding for this program — Federal obligations (CFDA 93.847). How funding has trended year over year.
| 2024 | $1,971,472,000 | |
| 2025 | $2,043,166,000 | |
| 2026 est. | $111,289,000 |
FAQ
Who is eligible to apply for this grant?
Only the current DISCOVERY Study consortium institutions and Biostatistics Research Center are eligible. This is a single-source, continuation-only solicitation.
What is the deadline and is it flexible?
The deadline is March 10, 2027. This is a fixed deadline; there is no rolling acceptance.
What activities can this grant support?
Funding supports ongoing study operations, longitudinal follow-up, data management, statistical analysis, quality assurance, and consortium coordination activities.
How competitive is this grant?
As a single-source award for continuation of an established consortium, competition is limited to current participants. The focus is on completing the study's scientific objectives with established infrastructure.
What is the funding level?
The total funding pool is $35 million for the entire consortium. Individual award amounts depend on site-specific needs and roles.
💡 Tips for applicants
- Emphasize the robustness of your existing infrastructure and standardized processes for managing the longitudinal dataset. Shows capacity to execute the continuation phase.
- Detail your track record on protocol implementation, data quality assurance, and inter-site coordination. Demonstrate how the consortium has successfully maintained study integrity.
- Align your continuation budget closely with the specific objectives remaining in the DISCOVERY Study timeline. Be explicit about what will be accomplished with requested funding.
- Include letters of support from participating clinical sites affirming commitment to completing the longitudinal follow-up phase. Strengthens the coherence of the consortium application.
- Highlight innovations or improvements in data management or statistical methodology that will enhance the quality of the ongoing follow-up cohort.
⚠️ Common mistakes
Applying as an ineligible institution. Only current DISCOVERY consortium members can apply; new sites cannot join through this continuation solicitation. Requesting budget that does not clearly align with specific remaining study objectives and timeline. Underestimating the administrative and coordination burden required for multi-center operations.
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