3C: Chronic Conditions, Coinfections, and Comorbidities in HIV
Can you apply?
This grant is for research institutions and investigators studying chronic conditions, coinfections, and comorbidities in HIV populations. Eligible applicants include 501(c)(3) organizations, academic institutions, and government agencies. Research must address HIV-related health complications like cardiovascular disease, cancer, or other chronic illnesses co-occurring with HIV infection.
The program supports investigator-initiated research projects examining how chronic conditions interact with HIV. Priority areas include understanding disease mechanisms, improving treatment outcomes, and reducing health disparities. International collaboration is permitted in some cases.
This is a competitive NIH program requiring strong preliminary data and clear research methodology. Applicants should align their work with current HIV research priorities and demonstrate feasibility.
Key dates
- Feb 6, 2026 Applications open
- Sep 25, 2026 Application deadline in 116 days
- Jul 22, 2027 Award announced
- Jul 22, 2027 Project start
This grant is for research institutions and investigators studying chronic conditions, coinfections, and comorbidities in HIV populations. Eligible applicants include 501(c)(3) organizations, academic institutions, and government agencies. Research must address HIV-related health complications like cardiovascular disease, cancer, or other chronic illnesses co-occurring with HIV infection.
The program supports investigator-initiated research projects examining how chronic conditions interact with HIV. Priority areas include understanding disease mechanisms, improving treatment outcomes, and reducing health disparities. International collaboration is permitted in some cases.
This is a competitive NIH program requiring strong preliminary data and clear research methodology. Applicants should align their work with current HIV research priorities and demonstrate feasibility.
Program description
NICHD will advance its mission by using the DP2 mechanism to support early-career investigators conducting pioneering research on HIV-related chronic conditions, coinfections, and comorbidities (3C). Scientific directions will be distinct from concepts and approaches already pursued and consistent with the scientific priorities of the Office of AIDS Research (OAR). HIV-related 3Cs cause significant and different pathology in people with and without HIV. Development of preventive and therapeutic strategies based on understanding HIV-specific pathways and mechanisms, and implementing those strategies is critical, especially in pediatric and maternal populations. All pediatric and maternal populations will be appropriate for study as the focus is on HIV prevention and/or treatment research. A pipeline of innovative researchers from other fields of research including mathematics, engineering, computer science, and AI will bring new ideas and innovative approaches. This NOFO will advance research on an important public health problem by supporting transformative research on HIV 3Cs by investigators in the early stages of an independent career.
Who can apply
Eligible applicants
- 501(c)(3) Public Charity
- City / Municipal Government
- County Government
- Hospital
- Nonprofits
- Private University
- Public Authority
- Public K-12 School
- Public University
- Small Business (SBA-defined)
- Special District
- State Government
- Tribal Nation
- Tribal Organization
Demographic focus
Details
This grant is for research institutions and investigators studying chronic conditions, coinfections, and comorbidities in HIV populations. Eligible applicants include 501(c)(3) organizations, academic institutions, and government agencies. Research must address HIV-related health complications like cardiovascular disease, cancer, or other chronic illnesses co-occurring with HIV infection.
The program supports investigator-initiated research projects examining how chronic conditions interact with HIV. Priority areas include understanding disease mechanisms, improving treatment outcomes, and reducing health disparities. International collaboration is permitted in some cases.
This is a competitive NIH program requiring strong preliminary data and clear research methodology. Applicants should align their work with current HIV research priorities and demonstrate feasibility.
How to apply
Application links
Key dates & requirements
Required documents
- SF-424 (R&R) Application Form
- Project Narrative (research plan)
- Detailed Budget and Budget Justification
- Biographical Sketches (key personnel)
- Institutional Support Letters
- Literature Cited
- Human Subjects Protection documentation (if applicable)
Program contact
- 👤 NICHD MPIDB
- 📧 NICHD_MPIDB_Opportunities@mail.nih.gov
- 📞 Please contact via e-mail
Funding track record
Recent awards under CFDA 93.865 from the last 3 years — real organizations that won funding through this same program.
Top 10 Largest Recent Awards
-
$1,059,454,555
-
$719,372,575
-
$276,059,721
-
$155,556,396
-
$155,482,198
-
$103,665,364
-
$74,151,078
-
$71,490,911
-
$52,238,426
-
$47,450,377
Top States by Funding
- WA 1 awards $1,059.5M
- NC 7 awards $921.5M
- MD 4 awards $493.9M
- MA 3 awards $190.0M
- PA 3 awards $145.1M
Source: USAspending.gov — federal spending transparency. Data covers last 3 years.
Funding history
Annual funding for this program — Federal obligations (CFDA 93.865). How funding has trended year over year.
| 2024 | $1,282,226,682 | |
| 2025 | $1,333,391,690 | |
| 2026 est. | $184,920,723 |
FAQ
Who can apply for ORACLE 3C funding?
Universities, medical centers, research hospitals, and 501(c)(3) nonprofit organizations with research capacity. Government agencies and tribal organizations may also apply.
What research topics are prioritized?
Studies examining chronic conditions, coinfections, and comorbidities in HIV-positive populations. Examples include cardiovascular disease, cancer, kidney disease, and mental health conditions.
What is the typical funding range?
NIH R-series grants typically range from $250,000 to $500,000 annually. Total project period budgets vary by grant mechanism; check the detailed CFDA description for specifics.
What makes an application competitive?
Strong preliminary data, experienced research team, clear methodology, and alignment with NIH priorities. Demonstrating innovation and feasibility increases chances of success.
When are applications due?
Check NIH grants.gov listing for current deadlines. Multiple submission dates may be available throughout the year.
💡 Tips for applicants
- Start with strong preliminary data showing proof of concept for your research hypothesis.
- Clearly connect your work to existing HIV treatment gaps and health disparities.
- Include a qualified research team with relevant HIV or chronic disease expertise.
- Address how your findings will impact HIV clinical care or patient outcomes.
- Use the NIH Research Portfolio Online Reporting Tools (RePORT) to identify similar funded projects.
⚠️ Common mistakes
Weak or insufficient preliminary data. Proposals lacking clear connection to HIV research priorities. Underestimating budget needs for proposed research scope.
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