HIV/AIDS Clinical Trials Network Statistical and Data Management Centers
Can you apply?
This grant is for organizations supporting HIV/AIDS clinical research networks through statistical and data management centers. Eligible applicants typically include research institutions, medical schools, teaching hospitals, and nonprofit research organizations with strong capacity in biostatistics and clinical trial management. The program supports centers that provide data management and statistical analysis services to HIV/AIDS clinical trial networks. Applicants must demonstrate expertise in clinical trial methodology and existing infrastructure for managing complex datasets from multi-site networks.
Key dates
- Apr 8, 2026 Applications open
- Jan 22, 2027 Application deadline in 223 days
- Dec 1, 2027 Award announced
- Dec 1, 2027 Project start
Program description
The National Institute of Allergy and Infectious Diseases (NIAID) seeks to advance the National Institutes of Health (NIH) mission by supporting four Clinical Trials Networks (CTNs) each comprised of a Leadership and Operations Center, Statistical and Data Management Center (SDMC), and Laboratory Center (LC) working with Clinical Trials Units (CTUs), to advance prevention, treatment, and implementation research on HIV and HIV-associated diseases. This NOFO will solicit applications for up to four SDMCs to provide leadership for developing and implementing each CTN research agenda with the goal of ending the HIV epidemic. Each SDMC will coordinate study design and execution, including data collection, monitoring, and analyses. SDMCs manage clinical and laboratory data submitted by CTUs and the LC ensuring data quality, regulatory compliance, and continual reporting of protocol and site performance. SDMCs foster innovative trial design and statistical methods, statistical and data practices harmonization, and ensure validated systems for data capture and integration, according to NIH data sharing policies.
Grant authorities that allow NIAID to forecast this opportunity are as follows: Sections 301 and 405 of the Public Health Service Act as amended (42 USC 241 and 284) and under Federal Regulations 42 CFR Part 52 and 2 CFR Part 200.
Who can apply
Eligible applicants
- 501(c)(3) Public Charity
- City / Municipal Government
- Colleges (all higher ed)
- County Government
- Hospital
- Nonprofits
- Private University
- Public Authority
- Public K-12 School
- Public University
- Small Business (SBA-defined)
- Special District
- State Government
- Tribal Nation
- Tribal Organization
Demographic focus
How to apply
Application links
Key dates & requirements
Required documents
- SF-424 (Federal Application for Grants and Cooperative Agreements)
- Project Narrative (research strategy)
- Detailed Budget and Budget Justification
- Curriculum Vitae (key personnel)
- Institutional Biosafety and Compliance Documentation
- Letters of Support from Clinical Trial Networks
- Data Management Plan
- Quality Assurance and Security Protocols
Program contact
- 👤 Division of AIDS
- 📧 sciops@niaid.nih.gov
- 📞 Please contact via e-mail.
Funding track record
Recent awards under CFDA 93.855 from the last 3 years — real organizations that won funding through this same program.
Top 10 Largest Recent Awards
-
$438,527,853
-
$246,626,852
-
$204,359,786
-
$201,437,825
-
$200,221,259
-
$185,816,804
-
$180,737,624
-
$136,265,880
-
$116,817,868
-
$99,478,296
Top States by Funding
- CA 10 awards $818.8M
- WA 3 awards $684.0M
- MA 6 awards $602.8M
- NC 3 awards $446.4M
- NY 7 awards $375.8M
Source: USAspending.gov — federal spending transparency. Data covers last 3 years.
Funding history
Annual funding for this program — Federal obligations (CFDA 93.855). How funding has trended year over year.
| 2024 | $4,073,812,529 | |
| 2025 | $4,378,235,639 | |
| 2026 est. | $4,299,426,996 |
FAQ
Who can apply for this grant?
Research institutions, medical schools, hospitals, and nonprofit research organizations with biostatistics and clinical trial expertise typically qualify. Your organization must have capacity to manage complex data from multi-site clinical networks.
What activities does this grant support?
Funding supports statistical analysis, data management infrastructure, quality assurance, and coordination services for HIV/AIDS clinical trial networks. It does not directly fund patient care or clinical treatment programs.
How competitive is this program?
This is highly competitive. Applications require demonstrated expertise in biostatistics, clinical trial management, and strong institutional research support. Previous experience managing large multi-site datasets is essential.
What is the typical funding range?
NIH clinical research grants vary widely, typically ranging from $250,000 to $500,000+ annually depending on scope. Check the FOA for specific budget guidance.
When should I start preparing?
Begin 4-6 months before the deadline. Assemble your biostatistics team and clinical trial management experts early.
💡 Tips for applicants
- Emphasize your organization's track record managing HIV/AIDS research data and multi-site clinical networks.
- Highlight biostatistical expertise, quality assurance protocols, and data security infrastructure clearly.
- Demonstrate how your center will improve data quality and accelerate trial completion timelines.
- Include letters of support from the clinical networks or sites you will serve.
- Align your proposed services with current priorities in HIV treatment and prevention research.
⚠️ Common mistakes
Vague descriptions of data management systems or statistical capacity. Lack of demonstrated experience with HIV/AIDS research or clinical trial networks. Insufficient detail on data security, regulatory compliance, and quality assurance procedures.
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