Precision and Systems Biology to Uncover the Link Between Chronic and Infectious Diseases
🏛 National Institutes of Health (HHS-NIH11)
✓ Free, no account · Source: Grants.gov · Last verified Jul 15, 2026
Can you apply?
This grant is for research institutions and consortiums conducting multidisciplinary systems biology research on links between chronic and infectious diseases. Applicants must have institutional research infrastructure and access to patient cohorts and biobank data. Projects must employ precision systems biology approaches, including multi-omics, computational modeling, and AI, with longitudinal patient data.
The grant supports research aimed at understanding disease pathways, host-pathogen interactions, and environmental factors. Eligible activities include genetic and lifestyle factor analysis, development of prevention strategies, and treatment innovations. This is a cooperative agreement requiring active collaboration with NIAID.
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Key dates
- Jun 24, 2026 Applications open
- Jan 22, 2027 Application deadline in 190 days
- Jan 1, 2028 Award announced
- Jan 1, 2028 Project start
Program description
The National Institute of Allergy and Infectious Diseases (NIAID) seeks to advance its mission by supporting multidisciplinary, consortium-based research using precision systems biology approaches to uncover links among chronic illnesses, infectious diseases and microbiomes. There is an urgent scientific and clinical need to understand the pathways by which infections lead to chronic lifelong health issues or alternatively, how long-term illnesses might predispose or exacerbate acute infections. The objective is to harness cutting-edge technologies along with longitudinal patient cohorts and biobank data for comprehensive analysis of genetic, environmental, and lifestyle factors leading to advances in prevention and treatment strategies for both chronic and infectious diseases. The cutting-edge technologies may include multi-omics, computational modeling, artificial intelligence, organoid-based validation systems, and integration of real-world data, alongside improved access to digital health records and advanced clinical informatics tools. The goal is to generate meaningful insights into disease progression and host-pathogen interactions. Grant authorities that allow NIAID to forecast this opportunity are as follows: Sections 301 and 405 of the Public Health Service Act as amended (42 USC 241 and 284) and under Federal Regulations 42 CFR Part 52 and 2 CFR Part 200.
Who can apply
Eligible applicants
How to apply
Application links
Key dates & requirements
Required documents
- SF-424 (R&R) or SF-424 (R&R) Cover Sheet
- Project Narrative/Research Strategy
- Specific Aims
- Significance and Innovation sections
- Research Design and Methods
- Budget and Budget Narrative
- Biographical Sketches (key personnel)
- Facilities and Resources
- Consortium/Contractual Arrangements (if applicable)
- Letters of Support (from partner institutions/data providers)
Program contact
- 👤 NIAID OGAT (Division of Microbiology and Infectious Diseases)
- 📧 NIAIDOGAT@mail.nih.gov
- 📞 Please contact via email.
Funding track record
Recent awards under CFDA 93.855 from the last 3 years — real organizations that won funding through this same program.
Top 10 Largest Recent Awards
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$246,626,852
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$201,437,825
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$185,816,804
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$180,737,624
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$136,265,880
-
$116,817,868
-
$93,394,862
-
$89,845,851
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$74,456,241
-
$72,987,380
Top States by Funding
- CA 8 awards $696.2M
- MA 6 awards $602.8M
- NY 6 awards $335.0M
- TX 3 awards $280.9M
- GA 5 awards $257.9M
Source: USAspending.gov — federal spending transparency. Data covers last 3 years.
Funding history
Annual funding for this program — Federal obligations (CFDA 93.855). How funding has trended year over year.
| 2024 | $4,073,812,529 | |
| 2025 | $4,378,235,639 | |
| 2026 est. | $4,299,426,996 |
FAQ
What types of institutions can apply for this grant?
Research institutions with established research infrastructure and institutional capacity can apply. Consortiums involving multiple organizations are particularly encouraged.
What is the deadline and how often does this grant open?
The fixed deadline is January 22, 2027. Check NIH's Center for Scientific Review or NIAID website for information on future funding cycles.
What research approaches are supported?
Projects using precision systems biology, multi-omics, computational modeling, AI, organoid validation, and integration of real-world data and digital health records are supported.
Is cost-sharing required?
No cost-sharing or matching funds are required for this grant.
How competitive is this funding opportunity?
As an NIH cooperative agreement with $17.5M total funding, competition is expected to be high. Strong preliminary data and established research teams are advantageous.
💡 Tips for applicants
- Emphasize multidisciplinary team composition with expertise spanning immunology, microbiology, bioinformatics, and clinical research.
- Highlight access to existing longitudinal patient cohorts and biobanks; describe data integration plans clearly.
- Demonstrate institutional capacity for managing cooperative agreements and multi-site coordination if consortium-based.
- Detail specific cutting-edge technologies (multi-omics platforms, AI models) your team will employ and your technical expertise.
- Connect research to clinical outcomes and translational impact; explain how findings advance prevention or treatment strategies.
⚠️ Common mistakes
Submitting single-discipline proposals lacking multidisciplinary collaboration across immunology, informatics, and clinical sciences. Underestimating the systems biology requirement; proposals focused only on traditional infection or chronic disease research alone without integrating both disease types. Insufficient detail on patient cohort characteristics, biobank data access, or longitudinal study design supporting the proposed research.
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