Immune Drivers of Autoimmune Disease
🏛 National Institutes of Health (HHS-NIH11)
✓ Free, no account · Source: Grants.gov · Last verified Oct 18, 2026
Can you apply?
This grant is for research institutions and networks studying autoimmune disease mechanisms. Eligible applicants typically include universities, medical centers, research institutes, and organizations with NIH-affiliated research capability. The network emphasizes collaborative research infrastructure and coordination across multiple institutions. Projects must focus on understanding immune mechanisms of autoimmunity and developing prediction/prevention tools.
The award supports a Network Coordinating Center and collaborative research projects through an Infrastructure Opportunity Fund. Applicants should have capacity for complex data harmonization, sample sharing, and administrative coordination. Cost-sharing is not required.
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Key dates
- Sep 24, 2026 Applications open
- Jun 11, 2027 Application deadline in 235 days
- Mar 1, 2028 Award announced
- Mar 1, 2028 Project start
Program description
The National Institute of Allergy and Infectious Diseases (NIAID) seeks to advance its mission through the continued support of the Immune Drivers of Autoimmune Disease (IDAD) network. This network aims to understand the earliest steps and triggers leading to autoimmunity and flare in humans, with the vision of ultimately preventing autoimmune disease. Priorities include discovering pre-clinical immune mechanisms, developing autoimmunity risk and staging prediction tools and biomarkers, building preclinical cohorts, leveraging remote recruitment and sampling, and artificial intelligence (AI)/big data. This complex, sustained collaboration relies on shared infrastructure to identify common triggers, pathways, and prevention opportunities. An Infrastructure Opportunity Fund (IOF) will be included in the initiative to provide the network the opportunity to conduct collaborative research projects. An IDAD Network Coordinating Center (NCC) will be responsible for administering the IOF and supporting additional coordinating activities amongst IDAD awardees, including the organization of Steering Committee meetings, resource sharing, data harmonization, sample sharing, and administering the IOF. Grant authorities that allow NIAID to forecast this opportunity are as follows: Sections 301 and 405 of the Public Health Service Act as amended (42 USC 241 and 284) and under Federal Regulations 42 CFR Part 52 and 2 CFR Part 2.
Who can apply
Eligible applicants
How to apply
Application links
Key dates & requirements
Required documents
- SF-424 (R&R)
- Project Narrative
- Budget and Budget Narrative
- Biographical Sketches
- Facilities and Resources
- Letters of Commitment (for partner institutions)
- Data Management and Sharing Plan
Program contact
- 👤 Division of Allergy, Immunology, and Transplantation
- 📧 IDAD_U01@mail.nih.gov
- 📞 Please contact via email.
Funding track record
Recent awards under CFDA 93.855 from the last 3 years — real organizations that won funding through this same program.
Top 10 Largest Recent Awards
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$246,626,852
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$201,437,825
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$197,316,803
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$180,737,624
-
$147,765,880
-
$116,817,868
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$93,394,862
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$89,845,851
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$85,436,674
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$84,525,882
Top States by Funding
- CA 9 awards $818.0M
- MA 6 awards $616.6M
- NY 8 awards $420.5M
- TX 3 awards $292.4M
- GA 5 awards $265.7M
Source: USAspending.gov — federal spending transparency. Data covers last 3 years.
Funding history
Annual funding for this program — Federal obligations (CFDA 93.855). How funding has trended year over year.
| 2024 | $4,073,812,529 | |
| 2025 | $4,378,235,639 | |
| 2026 est. | $4,299,426,996 |
FAQ
Who can apply for this grant?
Research institutions, universities, medical centers, and research organizations with NIH grant management capability. Networks and coordinating centers are primary focus areas. Applicants need infrastructure for data/sample management and collaboration.
What is the funding structure?
This is a cooperative agreement supporting a network with a Coordinating Center and Infrastructure Opportunity Fund. Funding supports both network administration and collaborative research projects within the network.
What research activities are supported?
Projects must focus on autoimmune disease mechanisms, immune triggers, biomarker development, cohort building, and AI/big data applications. Remote recruitment and sampling strategies are encouraged.
What is the deadline?
The deadline is June 11, 2027 (fixed). Applicants should check NIAID's website for any updates or reopen notices.
How competitive is this funding?
This is a highly competitive NIAID program. Strong applications require demonstrated research capability, collaborative infrastructure, and clear pathways to autoimmune disease prevention.
💡 Tips for applicants
- Emphasize network infrastructure and coordination capability. Collaborative research management is central to this award.
- Propose clear mechanisms for data harmonization and sample sharing across partner institutions. This is a key priority.
- Include strong biomarker and prediction tool development plans. Risk stratification is a major focus area.
- Leverage AI and big data approaches. The program explicitly prioritizes computational analysis and novel methods.
- Demonstrate access to patient cohorts or remote recruitment capacity. Building and accessing diverse autoimmune cohorts strengthens competitiveness.
⚠️ Common mistakes
Unclear network governance and coordination structure. Vague plans for data harmonization. Proposals lacking strong biomarker/prediction tool development strategies.
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