Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional)
Can you apply?
This grant is for organizations with existing active NIH research grants or cooperative agreements seeking additional funding for specific research aims or activities.
Eligible applicants include universities, medical schools, research institutions, nonprofit organizations, and some for-profit entities that currently hold NIH funding. The applicant must hold an active parent grant or cooperative agreement from NIH at the time of application.
Administrative supplements can fund new research directions, emerging opportunities, or amplification of existing work. Supplements may support clinical trials or other research activities aligned with the parent grant's scope.
Geographic scope is nationwide. Both domestic and international research may be eligible depending on the parent grant's terms.
This grant is for organizations with existing active NIH research grants or cooperative agreements seeking additional funding for specific research aims or activities.
Eligible applicants include universities, medical schools, research institutions, nonprofit organizations, and some for-profit entities that currently hold NIH funding. The applicant must hold an active parent grant or cooperative agreement from NIH at the time of application.
Administrative supplements can fund new research directions, emerging opportunities, or amplification of existing work. Supplements may support clinical trials or other research activities aligned with the parent grant's scope.
Geographic scope is nationwide. Both domestic and international research may be eligible depending on the parent grant's terms.
Program description
Current recipients of specific types of NIH research grants may apply for administrative supplements, using this Notice of Funding Opportunity (NOFO), to provide additional funding to a currently funded grant to meet increased costs that are within the scope of the peer-reviewed and approved project, but that were unforeseen when the new or competing renewal application was awarded. Applications for administrative supplements are considered prior approval requests (as described in Section 8.1.2.11 of the NIH Grants Policy Statement) and will be routed directly to the Grants Management Officer of the parent award. There is no guarantee that funds are available from the awarding IC or for any specific grant. Therefore, prior to submission, applicants must discuss potential requests with the awarding ICO grants and program officials.
Who can apply
Eligible applicants
- 501(c)(3) Public Charity
- City / Municipal Government
- Colleges (all higher ed)
- County Government
- Nonprofits
- Private University
- Public Authority
- Public K-12 School
- Public University
- Small Business (SBA-defined)
- Special District
- State Government
- Tribal Nation
- Tribal Organization
Details
This grant is for organizations with existing active NIH research grants or cooperative agreements seeking additional funding for specific research aims or activities.
Eligible applicants include universities, medical schools, research institutions, nonprofit organizations, and some for-profit entities that currently hold NIH funding. The applicant must hold an active parent grant or cooperative agreement from NIH at the time of application.
Administrative supplements can fund new research directions, emerging opportunities, or amplification of existing work. Supplements may support clinical trials or other research activities aligned with the parent grant's scope.
Geographic scope is nationwide. Both domestic and international research may be eligible depending on the parent grant's terms.
How to apply
Application links
Required documents
- Form PHS 2590 (Administrative Supplement Application)
- Project Narrative (Research Plan)
- Budget and Budget Justification
- Biosketch of key personnel (if required)
- Letters of support (if applicable)
Program contact
- 👤 National Institutes of Health
- 📧 GrantsPolicy@od.nih.gov
- 📞 301-402-2541
Funding track record
Recent awards under CFDA 93.310 from the last 3 years — real organizations that won funding through this same program.
Top 10 Largest Recent Awards
-
$973,507,476
-
$383,462,829
-
$190,396,050
-
$179,743,190
-
$169,422,678
-
$167,922,818
-
$143,679,156
-
$134,358,531
-
$115,739,255
-
$91,722,927
Top States by Funding
- NC 5 awards $1,419.5M
- WA 1 awards $383.5M
- MD 2 awards $303.8M
- NY 3 awards $192.1M
- NJ 1 awards $179.7M
Source: USAspending.gov — federal spending transparency. Data covers last 3 years.
Funding history
Annual funding for this program — Federal obligations (CFDA 93.310). How funding has trended year over year.
| 2024 | $1,174,839,078 | |
| 2025 | $1,062,277,534 | |
| 2026 est. | $28,100,048 |
FAQ
Who can apply for an administrative supplement?
Organizations with active NIH research grants or cooperative agreements. You must be the current awardee of the parent grant.
What can I use the supplement funding for?
Additional research activities related to your existing NIH grant. Common uses include new research directions, emerging opportunities, or expansion of current work.
Is there a limit on the funding amount?
Supplements are typically smaller than new grants. Exact limits vary by NIH institute or center.
How competitive is this compared to new grant applications?
Supplements are generally less competitive than de novo grants. Your existing NIH funding relationship is a strong asset.
When are applications due?
The deadline is typically November 30 each year, with some variation by NIH component. Check your specific institute's website for exact dates.
💡 Tips for applicants
- Start with your program officer early. They guide supplement strategy and strengthen your application.
- Link supplement activities directly to your parent grant's aims and budget period.
- Keep the narrative concise and focused. Supplements require shorter, tighter justifications than new grants.
- Explain the scientific rationale for timing. Show why this work is urgent or timely now.
- Ensure the supplement does not duplicate funding from other sources. Disclose all related support.
⚠️ Common mistakes
Not having a strong connection between supplement activities and existing parent grant scope. Vague or overly ambitious justification without clear, specific aims.
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