Accelerating Research and Development of Next Generation Malaria Vaccines Against Malaria – A Model for Mosquito-Borne Diseases
Can you apply?
This grant is for researchers and institutions pursuing malaria vaccine development and next-generation vaccine research. Eligible applicants typically include universities, research institutions, government labs, and 501(c)(3) nonprofits with research capacity. Domestic and international organizations may apply, but primary focus is U.S. research advancement. Activities supported include basic science, translational research, clinical trials, and vaccine platform development targeting malaria and mosquito-borne diseases. Priority given to innovative approaches and collaborations addressing global health challenges.
Key dates
- Apr 9, 2026 Applications open
- Feb 11, 2027 Application deadline in 243 days
- Dec 1, 2027 Award announced
- Dec 1, 2027 Project start
Program description
The National Institute of Allergy and Infectious Diseases (NIAID) seeks to support basic research, discovery, and/or preclinical development of highly efficacious vaccines for malaria and potentially other mosquito-borne illness. The program will encourage novel approaches to vaccine design that capitalize on recent technological innovations including structure-based immunogen design, and/or combination vaccines to reduce parasite infection and/or reduce malaria disease burden. Grant authorities that allow NIAID to forecast this opportunity are as follows: Sections 301 and 405 of the Public Health Service Act as amended (42 USC 241 and 284) and under Federal Regulations 42 CFR Part 52 and 2 CFR Part 200.
Who can apply
Eligible applicants
How to apply
Application links
Key dates & requirements
Required documents
- SF-424 (R&R) or SF-424 (R&R) Federal Delivery System
- Project Narrative (Research Strategy)
- Specific Aims page
- Research timeline
- Budget and Budget Narrative
- Biographical sketches of key personnel
- Letters of support from collaborating institutions
- Vertebrate Animals protocol (if applicable)
- Data Management and Sharing Plan
Program contact
- 👤 Malaria and Other Mosquito Borne Diseases
- 📧 MalariaandOtherMosquitoBorneDiseases@mail.nih.gov
- 📞 Please contact via e-mail.
Funding track record
Recent awards under CFDA 93.855 from the last 3 years — real organizations that won funding through this same program.
Top 10 Largest Recent Awards
-
$438,527,853
-
$246,626,852
-
$204,359,786
-
$201,437,825
-
$200,221,259
-
$185,816,804
-
$180,737,624
-
$136,265,880
-
$116,817,868
-
$99,478,296
Top States by Funding
- CA 10 awards $818.8M
- WA 3 awards $684.0M
- MA 6 awards $602.8M
- NC 3 awards $446.4M
- NY 7 awards $375.8M
Source: USAspending.gov — federal spending transparency. Data covers last 3 years.
Funding history
Annual funding for this program — Federal obligations (CFDA 93.855). How funding has trended year over year.
| 2024 | $4,073,812,529 | |
| 2025 | $4,378,235,639 | |
| 2026 est. | $4,299,426,996 |
FAQ
Who can apply for this grant?
Universities, research institutions, hospitals, nonprofits with research capacity, and some government agencies are eligible. International institutions may apply if they have U.S. partners or meet specific requirements.
What types of research are supported?
Basic science, translational research, clinical vaccine trials, and development of next-generation malaria vaccine platforms. Projects addressing mosquito-borne disease prevention through vaccine innovation are prioritized.
What is the typical funding range?
NIH R01 grants typically range from $100,000 to $500,000+ annually over 3-5 years. Actual awards vary by mechanism and scientific merit.
How competitive is this grant?
NIH grants are highly competitive. Success rates typically range 15-25% depending on the specific program. Strong preliminary data and experienced research teams are essential.
When should I apply?
The application open date is April 9, 2026. Check NIH Grants.gov for specific submission deadlines and instructions.
💡 Tips for applicants
- Focus on innovative approaches to malaria or mosquito-borne disease vaccines that advance beyond current options.
- Include strong preliminary data demonstrating feasibility and scientific merit of your proposed research.
- Build multi-disciplinary teams with expertise in vaccinology, immunology, entomology, and relevant infectious disease areas.
- Address global health impact and relevance to WHO or international malaria elimination goals.
- Use NIH eRA Commons early to check eligibility and familiarize yourself with application system.
⚠️ Common mistakes
Applications often lack sufficient preliminary data to support feasibility claims. Teams without demonstrated research infrastructure or relevant publications rarely succeed. Proposals may underestimate regulatory pathway complexity or clinical translation timelines for vaccine development.
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