Investment Partnerships Program (HOME) 2024 Program Activities reopened NOFA
🏛 Department of Housing and Community Development (California)
✓ Free, no account · Source: California Grants Portal · Last verified Nov 1, 2026
Can you apply?
This grant is for research institutions and community organizations partnering to conduct precision medicine research in California.
Academic institutions (nonprofit) must lead or co-lead projects alongside community partners. Community partners can include nonprofits, community-based organizations, patient advocacy groups, community clinics, public entities, or Tribal organizations. All research must focus on California, with data from California populations.
Projects must address health disparities, include underrepresented populations as participants, and create a precision medicine asset (dataset, methodology, service, or database). Research must demonstrate commitment to recruiting and retaining participants from underrepresented groups.
Academic-academic partnerships are also eligible if the second institution adds capacity, expertise, or training opportunities.
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Program description
The HOME Program is a federal formula grant program that provides annual allocations to states to increase and preserve the supply of decent, safe, and sanitary affordable housing specifically for serving low-income [at or below 80 percent (80%) of Area Median Income (AMI)] and very low-income [at or below 50 percent (50%) of AMI] households. This NOFA is to make available unclaimed HOME 2024 NOFA Program Activities funding, on an over-the-counter basis, until the next HOME Program Activities NOFA is released or funds are exhausted. With this funding, the Department will award HOME funds to eligible applicants on a first-come, first-served basis, in the form of loans/grants to fund Program Activities including first-time homebuyer programs, owner-occupied rehabilitation programs, and tenant-based rental assistance programs.
Who can apply
Eligible applicants
- 501(c)(3) Public Charity
- Community Health Center
- HBCU
- Nonprofits
- Public Authority
- Public University
- Small Business (SBA-defined)
- Tribal Nation
Demographic focus
How to apply
Application links
Key dates & requirements
Required documents
- Letter of Intent
- Initial Application materials
- Full Application/Project Narrative
- Budget and budget justification
- Letters of commitment from all partner organizations
- Evidence of community partnerships
- Recruitment and retention plan for underrepresented populations
- Precision medicine asset description
Program contact
- 📧 homeprograms@hcd.ca.gov
- 📞 1-916-890-9745
Funding track record
Past applications & awards under this program (California Grants Portal) — how competitive it is.
By fiscal year
| Fiscal year | Applications | Awarded | Award rate |
|---|---|---|---|
| 2025-2026 | 34 | 16 | 47% |
Source: California Grants Portal
FAQ
What counts as a "representative precision medicine asset"?
Examples include new or integrated datasets, methodology, services, online resources, or databases accessible to patients or researchers. Your project must deliver at least one asset.
Do I need a community partner?
Yes. Lead institutions must partner with either a nonprofit community organization, patient advocacy group, clinic, public/Tribal entity, or another academic institution that adds capacity and expertise.
What's the timeline for this grant?
Letter of Intent due 11/21/25, Initial Application 1/23/26, Full Application 4/24/26. Project duration is 2.5 years.
How much funding should we request?
Awards range from $1.2 million to $2 million. Approximately 3-5 projects will be funded from the $6 million pool.
What populations should our research focus on?
Projects must prioritize recruiting underrepresented populations historically excluded from biomedical research. Include data on social determinants of health where relevant.
💡 Tips for applicants
- Form partnerships early. Spend time building trust and alignment with community partners before drafting your proposal.
- Document underrepresentation. Clearly define which populations your research will prioritize and why they've been historically excluded from research.
- Plan your asset deliverable. Specify exactly what dataset, methodology, or resource you'll create and how it will benefit future research.
- Address health disparities explicitly. Connect your precision medicine approach directly to reducing health disparities in your target communities.
- Create strong recruitment materials. Plan promotional materials early that will appeal to underrepresented populations and explain research value in clear, accessible language.
⚠️ Common mistakes
Applications fail when partnerships feel transactional rather than truly collaborative. Community voices must shape research direction, not just participate. Projects that focus only on basic science without clear health disparity reduction are less competitive. Missing a precision medicine asset or unclear plans for community engagement and recruitment hurt chances.
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