Clinical Data Ecosystem for Genomics (CDEG)
🏛 National Institutes of Health (HHS-NIH11)
✓ Free, no account · Source: Grants.gov · Last verified Jul 15, 2026
Can you apply?
This grant is for research institutions, universities, and collaborative teams building clinical infrastructure for genomic data sharing. Eligible applicants must have expertise in genomic medicine, implementation science, computational genomics, data science, or electronic health record systems. The project must establish or strengthen a network ecosystem that enables sharing and standardization of genome sequencing data across healthcare settings. Projects demonstrating collaboration across clinical, computational, and informatics expertise are strongly encouraged.
Specific focus areas include creating APIs for data access, developing open-source clinical software, demonstrating data portability across healthcare systems, and producing implementation resources for broader adoption. This is a competitive research opportunity supporting infrastructure development rather than traditional basic science.
Not the right fit? Find grants for your organization in 5 questions →
Key dates
- Jul 17, 2025 Applications open
- Mar 2, 2026 Application deadline
- Oct 30, 2026 Award announced
- Oct 30, 2026 Project start
Program description
The National Human Genome Research Institute (NHGRI) intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for research reduce barriers to a Clinical Data Ecosystem for Genomics (CDEG) by establishing a network to identify, share, and improve approaches for clinical integration and sharing of genome sequencing data and their interpretation as structured data among labs, health care providers, and patients. Specifically, the Network will: 1) establish a pilot ecosystem that demonstrates best practices for the sharing of genomic structured data (GSD) across different health care settings, including primary care; 2) create standardized application programming interfaces (APIs) to support access to such data; 3) develop open-source clinical software applications and databases that utilize these APIs; 4) demonstrate the ability of the pilot ecosystem to overcome barriers to accessing patient genomic data as patients travel across healthcare systems; and 5) refine and develop these practices into implementation resources for broader sharing and adoption. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the U01 activity code. Investigators with expertise and insights into this area of genomic medicine and implementation science are encouraged to begin to consider applying for this new NOFO. In addition, collaborative investigations combining expertise in computational genomics and data science, electronic health records (EHR), genomic data standards, cloud and database development, health information exchange, and implementing genomics in clinical care will be encouraged and these investigators should also begin considering applying for this application.
Who can apply
Eligible applicants
How to apply
Application links
Key dates & requirements
Required documents
- SF-424 (R&R) Form
- Project Narrative/Research Plan
- Budget and Budget Justification
- Biographical Sketches
- Letters of Support from institutional partners
- Data Management and Sharing Plan
- Facilities and Resources description
- Environment and Safety information (if applicable)
Program contact
- 👤 Jennifer Troyer National Human Genome Research Institute (NHGRI)
- 📧 jennifer.troyer@nih.gov
- 📞 301-312-3276
Funding track record
Recent awards under CFDA 93.172 from the last 3 years — real organizations that won funding through this same program.
Top 10 Largest Recent Awards
-
$39,531,110
-
$34,574,245
-
$32,186,204
-
$30,195,606
-
$26,495,937
-
$26,020,371
-
$24,964,130
-
$24,413,854
-
$23,757,911
-
$22,977,417
Top States by Funding
- CA 19 awards $317.2M
- MA 16 awards $302.5M
- WA 9 awards $140.1M
- NY 6 awards $93.6M
- NC 5 awards $93.0M
Source: USAspending.gov — federal spending transparency. Data covers last 3 years.
Funding history
Annual funding for this program — Federal obligations (CFDA 93.172). How funding has trended year over year.
| 2024 | $452,727,668 | |
| 2025 | $423,878,429 | |
| 2026 est. | $9,989,158 |
FAQ
Who can apply for this grant?
Research institutions, universities, and collaborative consortia with expertise in genomics, health informatics, and clinical data systems. Teams combining computational genomics, EHR expertise, and clinical implementation are especially competitive.
What is the deadline?
March 2, 2026. This is a fixed deadline, so applications must be submitted by 5 PM ET on that date.
What types of projects are funded?
Projects establishing or expanding pilot ecosystems for genomic data sharing across healthcare settings. Funded work includes standardizing data formats, building APIs, creating clinical software, and demonstrating data exchange between healthcare systems.
How much can we request?
Award amounts are not specified in the NOFO announcement. Contact NHGRI program staff for funding ranges or review similar NIH U01 awards for guidance.
When will this NOFO open?
The announcement states applications are not being solicited at this time. This notice allows applicants to plan collaborations before the formal NOFO is released.
💡 Tips for applicants
- Start building collaborative relationships now. The announcement explicitly encourages investigators from different disciplines to connect before formal submission.
- Emphasize how your project removes barriers to clinical data access. Focus on real-world healthcare system challenges and your solutions.
- Demonstrate sustainability and broader adoption potential. Include plans for how results will be scaled beyond your pilot ecosystem.
- Highlight institutional commitment to genomic data sharing infrastructure. Letters of support from healthcare partners and clinical leadership strengthen competitiveness.
- Address both technical and implementation science expertise. Proposals combining software developers, clinicians, and health systems experts are more competitive.
⚠️ Common mistakes
Submitting proposals that focus narrowly on research discovery rather than infrastructure and implementation. CDEG prioritizes ecosystem building and standardization, not novel genomic findings.
Failing to demonstrate real collaboration across disciplines. Applications without clear evidence of partnerships between computational, clinical, and health informatics teams are less competitive.
Underestimating the importance of open-source and interoperability design. Proposals must show commitment to APIs, standards, and tools usable beyond the primary institution.
Similar grants
- OPEN Genomic Community Resources (U24 Clinical Trials Not Allowed) — National Institutes of Health
- CLOSED Computational Modeling and Analysis of the Impact of Genomic Variation on Function (UM1, Clinical Trial Not Allowed) — National Institutes of Health
- OPEN Data Coordinating Center for Multi-Site Investigator-Initiated Clinical Trials (Collaborative U24 Clinical Trial Required) — National Institutes of Health
- OPEN Research Grants in Clinical Informatics (R01 Clinical Trial Optional) — National Institutes of Health
- OPEN Integrating Biospecimen Science Approaches into Clinical Assay Development (U01 Clinical Trial Not Allowed) — National Institutes of Health