GREGoRi Innovation Projects (U01 Clinical Trial Optional)
🏛 National Institutes of Health (HHS-NIH11)
✓ Free, no account · Source: Grants.gov · Last verified Jul 16, 2026
Can you apply?
This grant is for researchers and research institutions seeking to fund innovative clinical trial projects through the GREGoRi (Genetic Research Evaluation in GERiatrics) program. Eligible applicants typically include universities, medical schools, teaching hospitals, independent research institutes, and other NIH-recognized research organizations with institutional infrastructure. Funding supports research that advances understanding of genetic and genomic factors in geriatric health outcomes. The U01 mechanism is designed for collaborative research projects with strong investigator teams. This program prioritizes research with direct clinical relevance and potential to impact aging-related health conditions. Projects must have appropriate IRB approval and institutional commitment for clinical work.
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Key dates
- Jun 18, 2026 Applications open
- Jul 6, 2026 Award announced
- Jul 6, 2026 Project start
- Oct 30, 2026 Application deadline in 105 days
Program description
The National Human Genome Research Institute (NHGRI) intends to promote a new initiative by publishing a Notice of Funding Opportunity (NOFO) to solicit applications for research on proof of concept studies that explore novel strategies for identifying the gene(s) or variant(s) underlying rare genetic disorders, which take advantage of new and emerging molecular technologies. A primary goal of this initiative is to move beyond the current state of the art approach that uses DNA sequencing-based methods as an initial step. Examples of work that would be within scope include pilot studies using emerging technology like multi-omics, or that evaluate the effectiveness of using molecular methods like RNA-seq or methylation as an initial step. Technologies that show potential in these proof of concept studies will be integrated into the activities of the Technology Integration Center in later years.
This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. The NOFO is expected to be published in 2025 with an expected application due date in 2026. This NOFO will utilize the U01 activity code.
Who can apply
Eligible applicants
- 501(c)(3) Public Charity
- County Government
- Hospital
- Private University
- Public Authority
- Public K-12 School
- Public University
- Small Business (SBA-defined)
- State Government
- Tribal Nation
- Tribal Organization
Demographic focus
How to apply
Application links
Key dates & requirements
Required documents
- SF-424 (R&R) form and cover letter
- Project narrative (specific aims, background, significance, innovation, approach, timeline)
- Budget and budget justification (detailed for Year 1, summary for subsequent years)
- Biographical sketches (NIH form) for all senior/key personnel
- Institutional commitments and letters of support
- IRB approval letter or documentation of IRB submission plan
- Letters of collaboration from partner sites (if multi-site study)
- Data and safety monitoring plan (for clinical trials)
- Human subjects protection plan
- Vertebrate animals section (if applicable)
Program contact
- 👤 Lisa H. Chadwick National Human Genome Research Institute (NHGRI)
- 📧 lisa.chadwick@nih.gov
- 📞 301-435-7275
Funding track record
Recent awards under CFDA 93.172 from the last 3 years — real organizations that won funding through this same program.
Top 10 Largest Recent Awards
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$39,531,110
-
$34,574,245
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$32,186,204
-
$30,195,606
-
$26,495,937
-
$26,020,371
-
$24,964,130
-
$24,413,854
-
$23,757,911
-
$22,977,417
Top States by Funding
- CA 19 awards $317.2M
- MA 16 awards $302.5M
- WA 9 awards $140.1M
- NY 6 awards $93.6M
- NC 5 awards $93.0M
Source: USAspending.gov — federal spending transparency. Data covers last 3 years.
Funding history
Annual funding for this program — Federal obligations (CFDA 93.172). How funding has trended year over year.
| 2024 | $452,727,668 | |
| 2025 | $423,878,429 | |
| 2026 est. | $9,989,158 |
FAQ
Who is eligible to apply for GREGoRi Innovation Projects?
Eligible institutions include research universities, medical schools, teaching hospitals, and NIH-recognized research organizations. Applicants must have established research infrastructure and typically require IRB approval capacity for clinical studies.
What is a U01 mechanism in NIH grants?
A U01 is a cooperative agreement supporting collaborative research projects, typically involving multiple investigators or sites working on a defined research problem. It allows for more NIH programmatic involvement than traditional R01 grants.
What types of research does GREGoRi fund?
GREGoRi supports research on genetic and genomic factors related to aging and geriatric health. This includes basic investigation, translational work, and clinical trials examining how genetics influence age-related outcomes.
When is the application deadline?
The specific deadline date should be verified at grants.nih.gov or the NIH funding opportunity page, as multiple submission dates may be available throughout the year.
What is the typical funding range?
NIH U01 awards typically range from $300,000 to $1,000,000+ annually depending on project scope and complexity. Exact amounts vary; check the official FOA for specific budgetary guidelines.
💡 Tips for applicants
- Ensure your research team is multidisciplinary and includes relevant expertise in geriatrics, genetics/genomics, and clinical research. NIH values collaborative approaches and established team dynamics.
- Align your project with current NIH priorities in aging research and precision medicine. Review recent GREGoRi-funded projects and the latest Strategic Plan for Aging Research.
- Develop a realistic clinical trial protocol with clear eligibility criteria, endpoints, and statistical power. NIH reviewers carefully evaluate feasibility and scientific rigor of clinical components.
- Build strong preliminary data demonstrating proof-of-concept. For a U01, you'll need convincing pilot work and preliminary results that justify the larger collaborative effort.
- Address health equity and inclusion explicitly in your research design, including recruitment and retention strategies for diverse aging populations. This is increasingly important in NIH review.
⚠️ Common mistakes
Applications often fail because investigators underestimate the complexity of multi-site coordination or provide insufficient preliminary data to support the clinical trial component. Another frequent issue is inadequate attention to regulatory compliance and IRB processes, or underestimating timeline and resource needs for long-term clinical work. Finally, proposals lacking clear connection to actionable clinical outcomes or precision medicine frameworks tend to be less competitive.
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