Intervention Research to Improve Native American Health (R34 Clinical Trial Optional)
🏛 National Institutes of Health (HHS-NIH11)
✓ Free, no account · Source: Grants.gov · Last verified Jul 15, 2026
Can you apply?
This grant is for research teams developing, testing, or implementing interventions to improve Native American health. Eligible applicants include universities, tribal organizations, nonprofits, federal agencies, and faith-based organizations. Tribal Controlled Colleges, Alaska Native Serving Institutions, and Indian tribal governments are priority eligible entities. Research must directly address health inequities in Native American populations using culturally informed approaches.
Funded research includes etiologic studies, intervention development and testing, treatment research, and dissemination/implementation strategies. Interventions should build on community strengths and be designed for sustainability and adaptation across communities. Projects may include pilot studies or feasibility testing of evidence-based interventions.
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Program description
The purpose of this notice of funding opportunity (NOFO) is to support research on interventions to improve health in Native American (NA) populations. This includes 1) etiologic research, where there is a significant gap in knowledge, that will directly inform intervention development or adaptations, 2) research that develops, adapts, or tests the efficacy or effectiveness of health promotion and disease prevention interventions, 3) research that tests culturally informed treatment or recovery interventions and 4) where a sufficient body of knowledge on intervention efficacy exists, research on dissemination and implementation that develops and tests strategies to overcome barriers to the adoption, integration, scale-up, and sustainability of effective interventions. Existing data suggest that significant acute and chronic disease inequities exist for NA populations. Concurrently, NA populations experience unique sociopolitical, historical, and environmental stressors and risks that may exacerbate health conditions and/or impact the effectiveness of existing solutions to address the conditions. They also possess unique strengths and resiliencies that can mitigate stressors or inform intervention strategies. Through this initiative, intervention and related research is sought to build upon community knowledge, resources, and resilience to test science-based, culturally appropriate solutions to reduce morbidity and mortality through identification and remediation of precursors to diseases and disorders and through culturally informed treatment. Interventions should be designed with a consideration for sustainability within the communities where they are tested, and have the flexibility to be readily adapted, disseminated, and scaled up to other communities where culturally appropriate. For the purposes of this NOFO, NA includes the following populations: Alaska Natives, American Indians (whose ancestral lands fall at least partially within the U.S. main land).
Who can apply
Eligible applicants
- 501(c)(3) Public Charity
- City / Municipal Government
- County Government
- Faith-based Organization
- Nonprofits
- Private University
- Public Authority
- Public K-12 School
- Public University
- Small Business (SBA-defined)
- Special District
- State Government
- TCU (Tribal Colleges)
- Tribal Nation
- Tribal Organization
Demographic focus
How to apply
Application links
Required documents
- SF-424 (R&R) form
- Project Narrative/Research Strategy
- Budget and Budget Justification
- Biographical Sketches (key personnel)
- Letters of Support or Institutional Commitment
- Tribal Consultation documentation (if applicable)
Program contact
- 👤 National Institutes of Health
- 📧 grantsinfo@nih.gov
- 📞 301-402-2541
Funding track record
Recent awards under CFDA 93.273 from the last 3 years — real organizations that won funding through this same program.
Top 10 Largest Recent Awards
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$125,900,663
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$34,675,742
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$34,469,501
-
$33,261,336
-
$32,897,567
-
$31,652,514
-
$30,394,602
-
$29,223,384
-
$29,195,978
-
$29,168,993
Top States by Funding
- CA 15 awards $242.3M
- NY 3 awards $162.6M
- OR 7 awards $96.3M
- NC 4 awards $67.1M
- IN 3 awards $57.4M
Source: USAspending.gov — federal spending transparency. Data covers last 3 years.
Funding history
Annual funding for this program — Federal obligations (CFDA 93.273). How funding has trended year over year.
| 2024 | $430,377,419 | |
| 2025 | $429,906,735 | |
| 2026 est. | $12,401,560 |
FAQ
Who can apply for this grant?
Universities, tribal governments, nonprofits, faith-based organizations, federal agencies, and community-based organizations are eligible. Foreign organizations cannot apply, but foreign components of U.S. organizations may be included.
What types of research does this grant fund?
Etiologic research, intervention development and adaptation, efficacy and effectiveness testing, treatment research, and dissemination/implementation studies. All research must focus on Native American health.
Do I need to match funding?
No cost-sharing is required for this grant.
How much can I request?
Award amounts are not specified in this NOFO. Contact NIH program staff for typical funding ranges for this mechanism.
What is the deadline?
The deadline is January 7, 2027. This appears to be a fixed deadline for this funding cycle.
💡 Tips for applicants
- Partner with Native American communities early in your project design. Community engagement and cultural appropriateness are core to this grant's priorities.
- Focus on sustainability: clearly explain how your intervention can be sustained by the community after funding ends.
- Address health inequities directly. Explain the specific disease burden or health gap your project targets in Native American populations.
- Design for adaptation. Show how your intervention could be modified and scaled to other Native American communities.
- Use existing data. Cite published research on health disparities, existing interventions, and community-identified needs to build your research case.
⚠️ Common mistakes
Failing to integrate community knowledge and cultural context into intervention design. Applications often neglect to demonstrate how interventions are adapted for specific tribal communities. Weak sustainability plans that don't show how communities will maintain the intervention long-term after funding ends.
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