Intervention Research to Improve Native American Health (R01 Clinical Trial Optional)
🏛 National Institutes of Health (HHS-NIH11)
✓ Free, no account · Source: Grants.gov · Last verified Oct 18, 2026
Can you apply?
This grant is for researchers conducting intervention research to improve health outcomes for Native Americans. Eligible applicants include academic institutions, government agencies, nonprofits, and tribal organizations with research capability. Projects must focus on clinical or behavioral interventions addressing Native American health disparities. Clinical trials are optional but strongly encouraged. Research can examine prevention, treatment, or health management strategies.
Funding supports the full research cycle from planning through dissemination. Both domestic and some international research sites may be eligible. Principal investigators must have research experience and institutional support. Tribal consultation and partnership with Native American communities is expected.
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Program description
Not available
Who can apply
Eligible applicants
- 501(c)(3) Public Charity
- City / Municipal Government
- County Government
- Nonprofits
- Private University
- Public Authority
- Public K-12 School
- Public University
- Small Business (SBA-defined)
- Special District
- State Government
- Tribal Nation
- Tribal Organization
Demographic focus
How to apply
Application links
Required documents
- SF-424 (R&R) form
- Project Narrative (Research Plan)
- Budget and Budget Justification
- Biographical Sketches (Key Personnel)
- Facilities and Resources
- Letters of Support (tribal partners, collaborators)
- Research Strategy (Aims, Significance, Innovation, Approach)
- Human Subjects Protection documentation
- Data Management Plan
Program contact
- 👤 National Institutes of Health
- 📧 grantsinfo@nih.gov
- 📞 301-402-2541
Funding track record
Recent awards under CFDA 93.839 from the last 3 years — real organizations that won funding through this same program.
Top 10 Largest Recent Awards
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$26,367,044
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$22,197,349
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$21,498,369
-
$20,132,449
-
$19,497,640
-
$17,136,580
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$16,771,574
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$14,584,323
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$14,229,448
-
$14,041,026
Top States by Funding
- MA 14 awards $130.7M
- PA 13 awards $116.1M
- CA 9 awards $93.4M
- NY 8 awards $80.4M
- WA 9 awards $66.1M
Source: USAspending.gov — federal spending transparency. Data covers last 3 years.
Funding history
Annual funding for this program — Federal obligations (CFDA 93.839). How funding has trended year over year.
| 2024 | $431,558,338 | |
| 2025 | $425,332,322 |
FAQ
Who can serve as the Principal Investigator?
PIs must have a doctoral degree (PhD, MD, DO, DVM, DPT, or equivalent) and demonstrated research experience. Tribal members and researchers from underrepresented groups are encouraged to apply.
What types of research are funded?
Intervention studies addressing Native American health disparities are eligible. Clinical trials, behavioral interventions, and implementation research are all acceptable approaches.
Is tribal partnership required?
Tribal consultation and community engagement are strongly expected. Direct tribal collaboration strengthens applications significantly.
How competitive is this funding?
R01 grants are highly competitive. Success rates typically range 15-25% across NIH. Strong preliminary data and innovation are essential.
What is the typical funding range?
R01 awards typically range $250,000 to $750,000 annually for 4-5 years. Exact amounts depend on project scope and research design.
💡 Tips for applicants
- Establish meaningful tribal partnerships early. Community input strengthens applications and increases funding success.
- Present strong preliminary data demonstrating intervention efficacy. Pilot studies or prior work are critical.
- Clearly articulate how research addresses specific health disparities affecting Native Americans. Be explicit about health impacts.
- Build a realistic timeline with adequate resources for community engagement. Rushing tribal consultation weakens applications.
- Address recruitment, retention, and cultural appropriateness explicitly. Demonstrate understanding of community needs and preferences.
⚠️ Common mistakes
Weak tribal engagement or lack of meaningful community partnership. Applications without established relationships often fail. Unclear health disparities or vague intervention targets. Reviewers need specific, measurable health outcomes. Insufficient preliminary data to justify feasibility.
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