Animal and Biological Material Resource Centers (P40 Clinical Trial Not Allowed)
🏛 National Institutes of Health (HHS-NIH11)
✓ Free, no account · Source: Grants.gov · Last verified Jul 16, 2026
Can you apply?
This grant is for organizations providing animal and biological material resource centers to the biomedical research community. Applicants must be U.S.-based entities; foreign organizations and non-domestic components of U.S. organizations are not eligible. The proposed center must have broad application across multiple NIH Institutes and Centers, serving local, regional, or national research communities. Both new and existing resource centers can apply if they align with ORIP's NIH-wide mission and include coordination with new approach methodologies (NAMs) like cell culture, organoids, and computational models.
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Program description
This Notice of Funding Opportunity (NOFO) encourages grant applications for Animal and Biological Material Resource Centers. These Centers provide support for special colonies of laboratory animals and associated services, as well as other resources such as informatics tools, reagents, cultures (cells, tissues, and organs) and genetic stocks that serve the biomedical research community in a variety of research areas on a local, regional, and national basis. The goal of projects supported by this NOFO is to provide research resources that facilitate optimization and enhancement of scientific rigor, transparency, and experimental reproducibility of biomedical research. Proposed Animal and Biological Material Resource Centers must have broad application to multiple NIH Institutes or Centers (ICs) to align with the ORIP”s NIH-wide mission (https://orip.nih.gov/about-orip). This funding opportunity is designed to support both continuation of existing resources and to develop new ones when appropriate. Of special interest of the announcement is a requirement of the Center”s close coordination with efforts to develop new approach methodologies (NAMs) that complement traditional animal-based research. These include cell culture, organoids, computational models, and microphysiological systems. Applied Research Component should include studies to generate comparative data to increase applicability of NAMs and promote integration of the most predictive human disease models. Prior to preparing an application, all applicants are strongly encouraged to consult with Scientific/Research staff to be advised on appropriateness of the intended resource plans for this program, competitiveness of a potential application, and ORIP’s program priorities.
Who can apply
Eligible applicants
How to apply
Application links
Key dates & requirements
Required documents
- SF-424 (Federal Application for Federal Assistance)
- Project Narrative
- Budget and Budget Justification
- Curriculum Vitae of key personnel
- Resource description and utilization plan
- Applied research component (comparative NAM data)
- Evidence of coordination with multi-institute research community
Program contact
- 👤 National Institutes of Health
- 📧 ORIPDCM@mail.nih.gov
- 📞 301-402-2541
Funding track record
Recent awards under CFDA 93.351 from the last 3 years — real organizations that won funding through this same program.
Top 10 Largest Recent Awards
-
$203,025,735
-
$201,841,608
-
$191,271,017
-
$156,271,917
-
$150,172,413
-
$133,830,113
-
$129,717,894
-
$37,946,246
-
$37,475,785
-
$33,594,411
Top States by Funding
- OR 7 awards $290.0M
- CA 8 awards $266.7M
- WA 2 awards $232.0M
- TX 9 awards $228.2M
- LA 6 awards $189.8M
Source: USAspending.gov — federal spending transparency. Data covers last 3 years.
Funding history
Annual funding for this program — Federal obligations (CFDA 93.351). How funding has trended year over year.
| 2024 | $279,889,905 | |
| 2025 | $284,089,258 | |
| 2026 est. | $283,084,958 |
FAQ
Who can apply for this grant?
U.S.-based organizations that maintain or plan to develop animal and biological material resource centers. Foreign organizations and foreign components of U.S. organizations are ineligible.
What types of resources are supported?
Laboratory animal colonies, reagents, cell cultures, tissues, organs, genetic stocks, and informatics tools. Centers must have broad application across multiple NIH institutes.
Is cost sharing required?
No cost sharing is required for this grant.
What is the application deadline?
The deadline is September 26, 2028. It is fixed and does not roll over.
Should I contact NIH before applying?
Yes. Applicants are strongly encouraged to consult with Scientific/Research staff about resource plans, competitiveness, and program priorities before submitting.
💡 Tips for applicants
- Consult with ORIP program staff before writing your application to confirm alignment and competitiveness. Early guidance improves success rates.
- Emphasize how your center serves multiple NIH institutes, not just one narrow research area. Broad utility is critical for competitiveness.
- Include a strong applied research component showing how your center coordinates with new approach methodologies like organoids and microphysiological systems.
- Demonstrate how your resource enhances scientific rigor, transparency, and reproducibility. These are core program goals.
- Clearly explain the comparative data you will generate to promote adoption of NAMs and human disease models in your research community.
⚠️ Common mistakes
Proposing a resource with only narrow application to a single institute or research area. Centers must demonstrate broad, multi-institute utility to be competitive. Failing to address how the resource coordinates with new approach methodologies (NAMs). The program requires explicit integration with cell culture, organoids, computational models, or microphysiological systems. Insufficient detail on the applied research component and comparative data that support NAM adoption and integration.
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