Resource Program Grants in Bioinformatics (P41 Clinical Trial Not Allowed)
🏛 National Institutes of Health (HHS-NIH11)
✓ Free, no account · Source: Grants.gov · Last verified Oct 18, 2026
Can you apply?
This grant is for institutions seeking to develop and maintain bioinformatics research resources. Eligible applicants include nonprofit organizations, universities, colleges, and government agencies with institutional infrastructure. Projects must support broad-use bioinformatics resources that benefit the NIH research community.
Applicants must demonstrate institutional commitment through cost-sharing. The resource must address gaps in existing tools and provide significant value to extramural researchers. Clinical trials are explicitly not allowed. Geographic scope is unrestricted for U.S. institutions.
Research focus areas include data management, computational tools, databases, and analytical platforms relevant to child health and human development research. Applicants must have access to sustained funding and technical expertise.
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Program description
The purpose of this Notice of Funding Opportunity (NOFO) is to support the continued operation, maintenance, and dissemination of unique database bioinformatics resources that are of major importance to the research community using animal models of embryonic developmental processes. These grants will support ongoing development and enhancement of the resources, user training and services, provision of community generated data storage and curation, wide dissemination of the tools and/or resources, and expansion of interoperability with other NIH bioinformatics resources.
Who can apply
Eligible applicants
How to apply
Application links
Required documents
- SF-424 (R&R)
- Project Narrative and Specific Aims
- Budget and Budget Justification
- Biosketch (key personnel)
- Data Management Plan
- Resource Description and Operational Plan
- Letters of Support from Anticipated Users
- Institutional Commitment Letter
- Facilities and Equipment
Program contact
- 👤 National Institutes of Health
- 📧 grantsinfo@nih.gov
- 📞 301-402-2541
Funding track record
Recent awards under CFDA 93.865 from the last 3 years — real organizations that won funding through this same program.
Top 10 Largest Recent Awards
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$1,073,967,938
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$719,372,575
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$282,005,487
-
$155,556,396
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$155,482,198
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$103,665,364
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$74,151,078
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$72,701,366
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$56,043,433
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$49,667,365
Top States by Funding
- WA 1 awards $1,074.0M
- NC 7 awards $928.6M
- MD 4 awards $513.0M
- MA 3 awards $190.0M
- PA 3 awards $151.4M
Source: USAspending.gov — federal spending transparency. Data covers last 3 years.
Funding history
Annual funding for this program — Federal obligations (CFDA 93.865). How funding has trended year over year.
| 2024 | $1,282,226,682 | |
| 2025 | $1,333,391,690 | |
| 2026 est. | $184,920,723 |
FAQ
Who can apply for this grant?
Universities, research institutions, nonprofit organizations, and government agencies can apply. Your institution must have the infrastructure to develop and maintain a bioinformatics resource.
Can I include clinical trial components?
No. Clinical trials are explicitly not allowed under this funding mechanism.
What should my resource address?
Your resource should fill a gap in existing bioinformatics tools. It should serve a broad audience of extramural researchers in child health and human development.
How competitive is this program?
Very competitive. Reviewers prioritize resources with demonstrated user demand and sustainability plans.
What is the typical funding range?
Resource grants typically fund between $200,000–$500,000 per year over 5 years, though amounts vary by project scope.
💡 Tips for applicants
- Demonstrate that no comparable bioinformatics resource currently exists or that your resource fills a clear gap. Provide user need data or letters of support.
- Include a detailed sustainability plan. Reviewers want to know how you'll maintain the resource after NIH funding ends.
- Build in cost-sharing or institutional commitment to show your organization values the resource long-term.
- Address data management, security, and accessibility upfront. NIH expects FAIR principles (Findable, Accessible, Interoperable, Reusable).
- Plan for user training and documentation. Resources succeed when researchers know how to use them effectively.
⚠️ Common mistakes
Applications fail when they lack a clear sustainability strategy or fail to demonstrate genuine user demand. Applicants often underestimate the operational costs of maintaining a resource long-term.
Reviewers reject proposals that duplicate existing resources without explaining the added value. Poor data management plans and unclear institutional commitment are red flags.
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