Continuation of the Collaborative Islet Transplantation Registry (U01 Clinical Trial Not allowed)
🏛 National Institutes of Health (HHS-NIH11)
✓ Free, no account · Source: Grants.gov · Last verified Jul 17, 2026
Can you apply?
This grant is for NIH-supported research institutions to continue participation in the Collaborative Islet Transplantation Registry. Eligible applicants include universities, medical centers, research institutions, and established clinical research programs with islet transplantation capabilities. The program supports registry continuation and data management activities rather than new clinical trials. Geographic scope is nationwide, and the work must advance islet transplantation research and outcomes tracking.
Applicants must have institutional infrastructure to support islet transplantation programs and existing patient populations or partnerships. An IRB and institutional support for human subjects research are required. Previous participation in the registry or a demonstrated commitment to islet transplant research is expected.
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Key dates
- Sep 22, 2025 Applications open
- Oct 1, 2026 Application deadline in 75 days
- Jul 1, 2027 Award announced
- Jul 1, 2027 Project start
Program description
The NIDDK, intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for research on collecting and analyzing data from clinical trials involving isolated human islets as a treatment for diabetes. This data will be used by research community for publications and presentations and to help design future clinical trials. Additionally, CITR will prepare periodic reports summarizing islet transplantation outcomes and trends overs time to inform the public. Additionally, CITR will conduct periodic meetings of the contributing sites. Applications are not being solicited currently. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the {U01 Clinical Trial Not Allowed Cooperative Agreement} activity code. Investigators with expertise and insights into this area of {Clinical Trial Data Collection} are encouraged to begin to consider applying for this new NOFO. In addition, collaborative investigations combining expertise in {Data Analyses} will be encouraged and these investigators should also begin considering applying for this NOFO.
Who can apply
Eligible applicants
How to apply
Application links
Key dates & requirements
Required documents
- SF-424 (R&R) application form
- Project Narrative (Research Strategy section)
- Budget and Budget Justification
- Biosketch(es) for key personnel
- Letters of institutional support
- Data management and quality assurance plan
- IRB approval or exemption documentation
Program contact
- 👤 Thomas L. Eggerman
- 📧 eggermant@extra.niddk.nih.gov
- 📞 301-594-8813
Funding track record
Recent awards under CFDA 93.847 from the last 3 years — real organizations that won funding through this same program.
Top 10 Largest Recent Awards
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$438,527,853
-
$200,221,259
-
$152,979,352
-
$112,529,392
-
$66,521,567
-
$45,186,589
-
$39,699,167
-
$37,490,770
-
$34,242,949
-
$31,624,784
Top States by Funding
- WA 3 awards $492.3M
- NC 4 awards $291.6M
- FL 2 awards $184.1M
- MA 6 awards $168.4M
- PA 6 awards $168.1M
Source: USAspending.gov — federal spending transparency. Data covers last 3 years.
Funding history
Annual funding for this program — Federal obligations (CFDA 93.847). How funding has trended year over year.
| 2024 | $1,971,472,000 | |
| 2025 | $2,043,166,000 | |
| 2026 est. | $111,289,000 |
FAQ
Who can apply for this grant?
Universities, medical schools, hospitals, and research institutions with active islet transplantation programs can apply. You must have institutional capacity to participate in registry activities.
What activities does this fund support?
This funds registry data collection, management, and analysis related to islet transplantation outcomes. It does not support new clinical trial initiation.
Is this a clinical trial grant?
No. The U01 clinical trial mechanism is explicitly not allowed. This funds observational registry work only.
What is the competitive landscape?
Competition is typically moderate to strong since awards go to established centers with existing islet transplant programs. Demonstrated track record in registry participation helps.
What is the typical award size?
NIH U01 registry continuation grants typically range from $200K-$500K annually, but check the specific NOFO for exact funding details.
💡 Tips for applicants
- Emphasize your institution's islet transplant expertise and current patient volume or partnerships.
- Highlight past registry participation and data quality contributions if applicable.
- Clearly describe your data management infrastructure and quality assurance processes.
- Address how you will recruit and retain transplant recipients for follow-up data collection.
- Align your proposed work with current NIH islet transplant research priorities and outcomes of interest.
⚠️ Common mistakes
Proposing new clinical trial activities. This registry grant explicitly excludes U01 clinical trial mechanisms. Lack of documented islet transplant program or patient population. Many applications fail due to insufficient institutional capacity or patient access.
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