Single Source for the Continuation of the Physiology of the Weight Reduced State (POWERS) Study (U01- Clinical Trials Required)
🏛 National Institutes of Health (HHS-NIH11)
✓ Free, no account · Source: Grants.gov · Last verified Jul 17, 2026
Can you apply?
This grant is for research institutions conducting clinical trials on weight reduction physiology. Research universities, medical centers, and NIH-funded research organizations can apply. The U01 mechanism requires significant research infrastructure and prior NIH funding experience. Activities include prospective human subject studies examining metabolic changes after weight loss. Geographic scope is U.S.-based institutions with appropriate IRB oversight.
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Key dates
- Sep 18, 2025 Applications open
- Jul 1, 2026 Application deadline
- Apr 1, 2027 Award announced
- Apr 1, 2027 Project start
Program description
The purpose of this NOFO is to continue the Physiology of the Weight Reduced State (POWERS) study. The goal of POWERS is to understand the physiological processes underlying individual variability in weight regain following weight loss. The continuation of POWERS will allow for the completion of the clinical trial and analysis of data and biospecimens.
Who can apply
Eligible applicants
How to apply
Application links
Key dates & requirements
Required documents
- SF-424 (R&R) forms
- Project Narrative and Specific Aims
- Research Strategy (Significance, Innovation, Approach)
- Budget and Budget Justification
- Biographical sketches of key personnel
- IRB approval letter or documentation
- Letters of commitment from collaborating institutions
- Data and Safety Monitoring Plan
- Human Subjects Protection documentation
Program contact
- 👤 Mary Evans, PhD
- 📧 NIDDK_Obesity@nih.gov
- 📞 301-594-4578
Funding track record
Recent awards under CFDA 93.847 from the last 3 years — real organizations that won funding through this same program.
Top 10 Largest Recent Awards
-
$438,527,853
-
$200,221,259
-
$152,979,352
-
$112,529,392
-
$66,521,567
-
$45,186,589
-
$39,699,167
-
$37,490,770
-
$34,242,949
-
$31,624,784
Top States by Funding
- WA 3 awards $492.3M
- NC 4 awards $291.6M
- FL 2 awards $184.1M
- MA 6 awards $168.4M
- PA 6 awards $168.1M
Source: USAspending.gov — federal spending transparency. Data covers last 3 years.
Funding history
Annual funding for this program — Federal obligations (CFDA 93.847). How funding has trended year over year.
| 2024 | $1,971,472,000 | |
| 2025 | $2,043,166,000 | |
| 2026 est. | $111,289,000 |
FAQ
Who can apply for this U01 grant?
Research institutions with established clinical research infrastructure and prior NIH funding are eligible. Individual researchers without institutional affiliation typically cannot apply.
What is the application deadline?
The deadline is rolling or ongoing. Check NIH's grants.gov site for current deadlines and target dates.
What activities does this grant fund?
Clinical trials examining physiology of weight loss. Longitudinal human subject studies are expected.
How competitive is this funding?
U01 grants are highly competitive. Strong preliminary data and established research teams are essential.
What is the typical funding range?
Multi-year research grants typically range $500K-$2M+ per year. Consult the CFDA or NIH website for specific guidance.
💡 Tips for applicants
- Demonstrate prior success with NIH grants and clinical trial management. Show track record with human subjects research.
- Build a strong interdisciplinary team including clinicians, nutritionists, and metabolic researchers. Collaboration strengthens competitiveness.
- Use preliminary data from pilot studies or existing cohorts. Preliminary results are critical for U01 applications.
- Address regulatory and ethical requirements clearly. Detail IRB approval, informed consent, and participant safety monitoring.
- Align study design with current obesity research priorities. Review recent NIH strategic plans and funded research areas.
⚠️ Common mistakes
Weak preliminary data or insufficient pilot data to support the proposed clinical trial. Underestimating timeline and resources needed for longitudinal human subject research. Unclear mechanisms linking weight loss physiology to specific health outcomes.
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