The Next Generation of the Clinical and Translational Science Awards Program Trial Innovation Network
🏛 National Institutes of Health (HHS-NIH11)
✓ Free, no account · Source: Grants.gov · Last verified Jul 21, 2026
Can you apply?
This grant is for eligible organizations seeking to improve multi-center clinical trial design and implementation. Applicants may include research institutions, academic medical centers, and clinical trial networks with demonstrated capacity in translational research. The program funds collaborative projects addressing clinical trial roadblocks such as safety monitoring, trial leadership, digital health integration, genomic capacity, and disease modeling. Geographic scope is national, with no state-specific restrictions.
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Key dates
- Jul 20, 2026 Applications open
- Jan 25, 2027 Application deadline in 187 days
- Dec 15, 2027 Award announced
- Dec 15, 2027 Project start
Program description
The Clinical and Translational Science Awards Program Trial Innovation Network (TIN) is a collaborative initiative aimed at addressing critical roadblocks in the design and implementation of multi-center clinical trials. The goal of the TIN is to execute trials better, faster, and more cost-efficiently, as well as serve as a national laboratory to study, understand, and innovate the process of conducting multi-center clinical trials. The purpose of the issuance of the Next Generation of the TIN Notice of Funding Opportunity (NOFO) is to advance the science of clinical trials by developing and implementing innovative solutions to address challenges at the clinical trial and trial network levels. Topics of interest include, but are not limited to, safety monitoring tools and resources, trial leader training and mentorship, digital health technologies, genomic capacity, and disease progression modeling.
Awards are made under the authorization of Sections 301 and 405 of the Public Health Service Act as amended (42 USC 241 and 284) and under Federal Regulations 42 CFR Part 52 and 2 CFR Part 200.
This is a Forecast that will invite applications from all eligible organizations to apply. Please see the Eligibility Section for additional information. In accordance with NIH standard peer-review processes, the applications will be peer-reviewed, and only meritorious applications will be considered for funding.
Who can apply
Eligible applicants
- 501(c)(3) Public Charity
- City / Municipal Government
- Colleges (all higher ed)
- Community Health Center
- County Government
- Hospital
- Nonprofits
- Private University
- Public Authority
- Public K-12 School
- Public University
- Small Business (SBA-defined)
- Special District
- State Government
- Tribal Nation
- Tribal Organization
How to apply
Application links
Key dates & requirements
Required documents
- SF-424 (R&R)
- Project Narrative
- Budget and Budget Justification
- Biographical Sketches (Key Personnel)
- Facilities and Resources
- Letters of Support/Commitment (for collaborative sites)
Program contact
- 👤 Division of Clinical Innovation, NCATS
- 📧 tin@nih.gov
- 📞 Please contact via e-mail.
Funding track record
Recent awards under CFDA 93.350 from the last 3 years — real organizations that won funding through this same program.
Top 10 Largest Recent Awards
-
$139,753,636
-
$118,592,298
-
$118,098,707
-
$112,138,469
-
$102,903,347
-
$102,422,256
-
$100,095,982
-
$99,978,264
-
$98,955,036
-
$97,784,066
Top States by Funding
- CA 13 awards $652.0M
- NY 11 awards $506.1M
- MA 6 awards $321.4M
- NC 5 awards $313.7M
- OH 5 awards $162.0M
Source: USAspending.gov — federal spending transparency. Data covers last 3 years.
Funding history
Annual funding for this program — Federal obligations (CFDA 93.350). How funding has trended year over year.
| 2024 | $595,597,945 | |
| 2025 | $626,227,752 |
FAQ
Who can apply for this grant?
Eligible organizations include research institutions, academic medical centers, clinical trial networks, and other entities with clinical trial expertise. Check the full NOFO for complete eligibility criteria and institutional requirements.
What is the deadline?
The application deadline is January 25, 2027. This is a fixed deadline; rolling submissions are not accepted.
What types of projects does TIN fund?
TIN supports innovation in clinical trial design and implementation, including safety monitoring tools, trial leader training, digital health technologies, genomic capacity building, and disease progression modeling.
Is this grant competitive?
Yes. Applications undergo NIH peer review, and only high-quality applications are funded based on scientific merit and alignment with program priorities.
Is cost-sharing required?
No cost-sharing is required for this grant. Applicants do not need to commit matching funds.
💡 Tips for applicants
- Emphasize how your project addresses multi-center trial roadblocks. Be specific about the clinical trial challenge you're solving.
- Demonstrate institutional capacity and partnerships. Multi-site collaboration strengthens applications for a network-focused program.
- Align your innovation with TIN priorities: safety monitoring, trial leadership, digital health, genomics, or disease modeling.
- Build a realistic, well-justified budget with clear deliverables. Show how funding translates to trial process improvements.
- Highlight scalability and dissemination plans. TIN aims to create national impact, not isolated solutions.
⚠️ Common mistakes
Proposing incremental improvements instead of innovative solutions to trial design or implementation. Insufficient evidence of multi-center collaboration or trial network engagement. Failing to demonstrate how the project will be scaled or disseminated nationally.
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