RNomics Technology Enhancement Centers
🏛 National Institutes of Health (HHS-NIH11)
✓ Free, no account · Source: Grants.gov · Last verified Oct 31, 2026
Can you apply?
This grant is for research institutions and collaborative teams developing RNA analysis technologies. Eligible applicants typically include academic research institutions, nonprofit research organizations, and eligible foreign institutions. The program focuses on strengthening existing technologies with demonstrated feasibility for measuring RNA in cells and tissues.
Project activities include advancing sequencing technologies, mapping RNA modifications, analyzing RNA structure and interactions, and developing tools for RNA manipulation and functional testing. Awards support multi-institutional collaborative centers that will make technologies broadly available to the research community.
This is a research-focused program requiring scientific and technical expertise in RNA biology and technology development. International collaboration is possible through partner institutions.
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Key dates
- Aug 5, 2026 Applications open
- Feb 1, 2027 Application deadline in 92 days
- Dec 1, 2027 Award announced
- Dec 1, 2027 Project start
Program description
The NIH Common Fund, in partnership with other NIH Institutes and Centers, plans to issue Notices of Funding Opportunity (NOFOs) for the RNomics program, which seeks to develop tools for studying the full set of RNA molecules (the RNome) in cells and tissues. The program will support technologies and resources that enable integrated analysis of RNA sequences, modifications, structures, locations, interactions, and functions to advance understanding of health and disease. RNomics includes four initiatives: technology enhancement centers, transformative technologies, molecular standards, and a coordinating center. Applications are not being solicited at this time. This notice is being provided to give potential applicants time to develop meaningful collaborations and strong projects.
This NOFO will establish collaborative RNomics Technology Enhancement Centers (RTECs). RTECs will further develop existing technologies with demonstrated feasibility. These centers will strengthen experimental and computational tools for measuring, mapping, and testing RNA in cells and tissues, with the goal of delivering measurable improvements and supporting broad community use. Priority areas include end-to-end RNA sequencing and quantitative modification mapping; comprehensive analysis of RNA sequence, structure, modification, interactions, localization, dynamics, and function; and molecular and biochemical tools for RNA manipulation, processing, and functional testing.
Who can apply
Eligible applicants
How to apply
Application links
Key dates & requirements
Required documents
- R24 Application Form (SF-424 Family)
- Project Narrative and Supporting Information
- Budget and Budget Narrative
- Biographical Sketches (key personnel)
- Letters of Institutional Support and Collaboration Agreements
- Description of Multi-Institutional Governance and Coordination Plan
Program contact
- 👤 Common Fund RNomics Program
- 📧 cfrnomics@od.nih.gov
- 📞 Please contact via email.
Funding track record
Recent awards under CFDA 93.310 from the last 3 years — real organizations that won funding through this same program.
Top 10 Largest Recent Awards
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$202,512,667
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$198,364,987
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$179,737,926
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$169,422,678
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$148,383,140
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$143,679,156
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$115,739,255
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$79,886,847
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$68,845,964
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$60,300,930
Top States by Funding
- CA 10 awards $548.0M
- MD 3 awards $326.7M
- NY 6 awards $193.0M
- NJ 1 awards $179.7M
- TN 2 awards $156.3M
Source: USAspending.gov — federal spending transparency. Data covers last 3 years.
Funding history
Annual funding for this program — Federal obligations (CFDA 93.310). How funding has trended year over year.
| 2024 | $1,174,839,078 | |
| 2025 | $1,062,277,534 | |
| 2026 est. | $28,100,048 |
FAQ
Who can apply for RNomics Technology Enhancement Centers?
Academic research institutions, nonprofit research organizations, and eligible foreign entities can apply. Applicant institutions must demonstrate capacity for collaborative, multi-disciplinary research.
When is the application deadline?
The deadline is February 1, 2027. This is a fixed deadline, so applications must be submitted by 11:59 PM ET on that date.
What types of projects does RNomics fund?
The program funds technology development in four areas: end-to-end RNA sequencing, RNA modification mapping, comprehensive analysis of RNA properties, and molecular tools for RNA manipulation and functional testing.
What makes a competitive RNomics application?
Strong applications demonstrate existing feasibility of core technologies, clear plans for improvement, multi-institutional collaboration, and commitment to making tools broadly available to the research community.
What is the funding range for these awards?
Awards can reach up to $2,000,000, with a total program funding pool of $12,000,000 available for all Technology Enhancement Centers.
💡 Tips for applicants
- Emphasize existing proof-of-concept and your plan to strengthen, not start from scratch. Reviewers favor technologies with demonstrated feasibility.
- Build a genuinely collaborative team across institutions with complementary expertise. Multi-institutional partnerships are essential for center success.
- Detail your strategy for making technologies available broadly to the research community. Sustainability and accessibility are evaluation priorities.
- Address how your center will integrate multiple RNA analysis approaches (sequence, structure, modification, localization, function). Comprehensive analysis is a key program goal.
- Clearly specify quantifiable milestones and deliverables for each year. Technology improvement must be measurable and trackable.
⚠️ Common mistakes
Many applications fail to show sufficient existing feasibility or proof-of-concept before proposing enhancement. Weak multi-institutional collaboration plans or unclear governance structures undermine center credibility. Applicants often underestimate community engagement needs—reviewers expect clear plans for broad dissemination and user support.
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