Resource-Related Research Projects Cooperative Agreements in Aging and/or Alzheimer’s Disease (AD) and Alzheimer’s Disease-Related Dementias (ADRD) Research
🏛 National Institutes of Health (HHS-NIH11)
✓ Free, no account · Source: Grants.gov · Last verified Aug 1, 2026
Can you apply?
This grant is for research institutions and organizations studying aging, Alzheimer's disease, and related dementias. Eligible applicants include universities, medical schools, research hospitals, nonprofit research organizations, and some for-profit entities with research capacity. Applicants must have institutional infrastructure, including IRB/IACUC oversight and appropriate research facilities. Domestic institutions are prioritized, though international collaborations may be permitted. Applications must focus on resource-related research projects that contribute to understanding AD/ADRD pathology, prevention, treatment, or care.
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Key dates
- Jan 22, 2026 Applications open
- Jun 26, 2026 Application deadline
- Apr 30, 2027 Award announced
- Apr 30, 2027 Project start
Program description
The National Institute on Aging (NIA) intends to publish a Notice of Funding Opportunity (NOFO) to invite new, renewal, and revision applications, and their resubmissions, for U24 Research Resource/Infrastructure cooperative agreements that support large-scale, complex research programs focused on aging and/or Alzheimer’s disease (AD) and Alzheimer’s disease-related dementias (ADRD) research. It is anticipated that such programs will likely involve a team of investigators from a single institution, or a consortium of institutions, and align with the mission and research priorities of NIA. If submitting renewal or revision applications, the research objectives and scope of applications submitted through this NOFO must adhere to the requirements outlined in the parent NOFO under which the original application was funded.
Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO intends to utilize the U24 activity code. Applicants should be aware that NIA anticipates funding only a limited number of meritorious applications under this announcement. Consultation with IC staff is strongly encouraged prior to the submission of an application to discuss the responsiveness of their proposed research to this NOFO and its relevance to NIA’s programmatic priorities.
Who can apply
Eligible applicants
- 501(c)(3) Public Charity
- City / Municipal Government
- County Government
- Nonprofits
- Private University
- Public Authority
- Public K-12 School
- Public University
- Small Business (SBA-defined)
- Special District
- State Government
- Tribal Nation
- Tribal Organization
Demographic focus
How to apply
Application links
Key dates & requirements
Required documents
- SF-424 (federal form)
- Project Narrative and Specific Aims
- Research Strategy (preliminary data, methods, innovation)
- Budget Narrative and Budget Form
- Biographical Sketches (key personnel)
- Current and Pending Support documentation
- Institutional Certifications and Assurances
- Letters of Support (if applicable)
Program contact
- 👤 NIA Scientific Contact
- 📧 NIA-NOFO-Scientific@nih.gov
- 📞 Please contact via e-mail.
Funding track record
Recent awards under CFDA 93.866 from the last 3 years — real organizations that won funding through this same program.
Top 10 Largest Recent Awards
-
$463,372,200
-
$172,327,224
-
$115,145,694
-
$99,649,073
-
$93,275,174
-
$82,572,681
-
$81,449,732
-
$78,657,309
-
$75,825,492
-
$75,398,895
Top States by Funding
- CA 10 awards $633.7M
- MI 2 awards $511.9M
- MO 8 awards $453.6M
- IN 4 awards $303.9M
- PA 6 awards $298.0M
Source: USAspending.gov — federal spending transparency. Data covers last 3 years.
Funding history
Annual funding for this program — Federal obligations (CFDA 93.866). How funding has trended year over year.
| 2024 | $3,746,886,731 | |
| 2025 | $3,777,464,644 | |
| 2026 est. | $261,814,471 |
FAQ
Who is eligible to apply for this grant?
Research institutions, universities, medical schools, hospitals, and nonprofit research organizations with established research infrastructure. For-profit entities may apply if they meet NIH research capacity standards.
What types of research projects are supported?
Resource-related research projects that advance knowledge in aging, Alzheimer's disease, and related dementias. This includes studies on disease mechanisms, prevention, treatment, diagnostics, and care models.
What is a cooperative agreement versus a standard grant?
A cooperative agreement involves active NIH involvement in project oversight. The NIH program officer works closely with investigators throughout the project period.
How competitive is this funding opportunity?
Very competitive. Applications compete against many high-quality research proposals. Strong preliminary data, experienced research teams, and clear innovation increase chances of success.
What budget range should I expect?
Budgets vary widely by project scope. Typical NIH research grants range from $100,000 to $500,000+ annually. Check the FOA for specific budget caps and guidance.
💡 Tips for applicants
- Establish strong preliminary data demonstrating feasibility of your research approach and team capability.
- Clearly articulate how your project is "resource-related" and explains the research infrastructure or resources your work provides.
- Build in time to work with an NIH program officer; they will guide you during the cooperative agreement.
- Address diversity and inclusion in your research team, recruitment strategy, and study populations where relevant.
- Use the NIH eRA Commons system early to verify your institution's registration and access permissions before submitting.
⚠️ Common mistakes
Weak or insufficient preliminary data showing feasibility is a primary rejection reason. Applicants often fail to clearly define how their project qualifies as "resource-related" or describe the specific resource being developed. Unclear or unrealistic timelines and budgets, mismatched to project scope, frequently lead to unfavorable reviews.
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