Personal Health Informatics for Delivering Actionable Insights to Individuals (R01 Clinical Trial Optional)
Can you apply?
This grant is for biomedical researchers developing health informatics systems. Academic institutions, research hospitals, and nonprofit research organizations typically qualify. The grant supports R01-level research on personal health information systems that deliver actionable health insights to individuals. Clinical trials are optional but encouraged.
Researchers must have a strong track record and institutional support. International organizations may apply through specific NIH pathways. This is a competitive, merit-based program focused on innovative research methodologies.
Eligible activities include research design, system development, validation studies, and pilot testing. Data collection and analysis related to personal health informatics are supported. The research must demonstrate clear potential to improve individual health outcomes through better information delivery.
This grant is for biomedical researchers developing health informatics systems. Academic institutions, research hospitals, and nonprofit research organizations typically qualify. The grant supports R01-level research on personal health information systems that deliver actionable health insights to individuals. Clinical trials are optional but encouraged.
Researchers must have a strong track record and institutional support. International organizations may apply through specific NIH pathways. This is a competitive, merit-based program focused on innovative research methodologies.
Eligible activities include research design, system development, validation studies, and pilot testing. Data collection and analysis related to personal health informatics are supported. The research must demonstrate clear potential to improve individual health outcomes through better information delivery.
Program description
The purpose of this Notice of Funding Opportunity (NOFO) is to advance the development of novel informatics and data science approaches that can help individuals understand and improve their health through actionable insights. NLM seeks applications that further the science of personal health informatics by providing meaningful and actionable insights to individuals through innovative personal health data collection, integration, analysis, and personalized risk assessments and interpretation. Applications seeking to advance the understanding of how informatics tools, systems, and platforms can best present the results, interpretation, and limitations of personalized assessments for the benefit of individuals are encouraged. Applications should include end user engaged approaches and real-world evaluation to inform the design of generalizable, reusable, and scalable personal health informatics tools, systems, and platforms for the benefit of individuals in understanding and improving their health.
Who can apply
Eligible applicants
- 501(c)(3) Public Charity
- City / Municipal Government
- County Government
- Nonprofits
- Private University
- Public Authority
- Public K-12 School
- Public University
- Small Business (SBA-defined)
- Special District
- State Government
- Tribal Nation
- Tribal Organization
Details
This grant is for biomedical researchers developing health informatics systems. Academic institutions, research hospitals, and nonprofit research organizations typically qualify. The grant supports R01-level research on personal health information systems that deliver actionable health insights to individuals. Clinical trials are optional but encouraged.
Researchers must have a strong track record and institutional support. International organizations may apply through specific NIH pathways. This is a competitive, merit-based program focused on innovative research methodologies.
Eligible activities include research design, system development, validation studies, and pilot testing. Data collection and analysis related to personal health informatics are supported. The research must demonstrate clear potential to improve individual health outcomes through better information delivery.
How to apply
Application links
Required documents
- SF-424 (R&R) Federal Application Form
- Project Narrative
- Specific Aims (1 page)
- Research Strategy (including preliminary data, methods, timeline)
- Budget and Budget Justification
- Biographical Sketches (all key personnel)
- Institutional Support Letter
- IRB/Ethics Approval or Protocol
- Letters of Collaboration (if applicable)
Program contact
- 👤 National Institutes of Health
- 📧 grantsinfo@nih.gov
- 📞 301-402-2541
Funding track record
Recent awards under CFDA 93.242 from the last 3 years — real organizations that won funding through this same program.
Top 10 Largest Recent Awards
-
$75,056,208
-
$74,756,329
-
$72,845,834
-
$64,705,159
-
$63,991,707
-
$54,214,022
-
$38,895,082
-
$38,475,557
-
$34,635,977
-
$34,475,710
Top States by Funding
- CA 15 awards $408.1M
- MA 9 awards $230.3M
- NY 6 awards $184.2M
- WA 4 awards $174.9M
- CT 3 awards $138.9M
Source: USAspending.gov — federal spending transparency. Data covers last 3 years.
Funding history
Annual funding for this program — Federal obligations (CFDA 93.242). How funding has trended year over year.
| 2024 | $1,722,300,004 | |
| 2025 | $1,726,864,191 | |
| 2026 est. | $99,221,272 |
FAQ
Who can apply for this R01 grant?
PhD or MD researchers at academic institutions, research hospitals, and nonprofit research organizations. Your institution must have a Federal-wide Assurance (FWA) and institutional biosafety committee.
What is the typical funding range?
R01 grants typically award $200,000–$500,000 per year over 3–5 years. Actual amounts depend on scientific scope and reviewer scores.
Can I include a clinical trial component?
Yes, clinical trials are optional. You may propose observational studies, informatics research, or clinical validation without a full trial.
How competitive is this funding?
Very competitive. Success rates for NIH R01s typically range 15–25%. Strong preliminary data and innovation are critical.
What's the application deadline?
January 7, 2027. Applications open November 21, 2024. Submit at least 2 days before the deadline to avoid technical issues.
💡 Tips for applicants
- Establish preliminary data early. Reviewers expect pilot results showing feasibility before funding.
- Build a strong team. Include biostatisticians, informaticians, and clinical collaborators with relevant expertise.
- Focus on actionability. Clearly explain how your system delivers insights individuals can actually use.
- Address privacy and security proactively. Detail your data protection, consent, and ethical safeguards.
- Align with NIH strategic priorities. Reference relevant NIH initiatives on digital health and precision medicine.
⚠️ Common mistakes
Lack of preliminary data weakens applications. Vague descriptions of how insights are delivered to users fail to justify innovation. Weak data security or privacy plans raise reviewer concerns about feasibility and ethics.
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