Animal Genomics Program (U01 Clinical Trial Not Allowed)
🏛 National Institutes of Health (HHS-NIH11)
✓ Free, no account · Source: Grants.gov · Last verified Oct 18, 2026
Can you apply?
This grant is for researchers studying substance use disorder and addiction through animal genomics research. Eligible applicants include universities, medical schools, research institutes, and other NIH-recognized research organizations. Domestic and foreign institutions can apply, but at least one applicant organization must be domestic. Projects must involve animal genomic studies related to drug addiction but cannot include clinical trials involving human subjects.
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Program description
The purpose of the NIDA Animal Genetics Program is to identify genetic, genomic, and molecular (epi)genetic variants that underlie: 1. Phenotypes associated with addictive behaviors and/or vulnerability to distinct stages along the substance use disorders (SUD) trajectory (e.g. initial/acute use, escalation of use, acquisition of tolerance, dependence, uncontrolled use, abstinence and relapse or recovery); 2. Behaviors associated with SUD (e.g. impulsivity, novelty seeking, delayed discounting, and other genetically-associated phenotypes); and 3. Comorbidities that demonstrate genetic correlations with phenotypes and behaviors linked with SUD (e.g. anxiety, stress, poor maternal care, social defeat, and other paradigms). Applications may examine any type of genomic variant, including single nucleotide variants (SNVs), indels, large and small structural variants, and all types of mobile DNA. NIDA encourages applications that take genomics, multi-omics, and/or data-based approaches that integrate multi-level omics data, delineate gene networks, and/or uncover the function of known or newly discovered genetic or epigenetic variants. Other areas of interest include genomics analysis at the circuit level and the application of neuroscience to genomics studies. NIDA expects these studies to uncover novel mechanisms that contribute to various stages across the SUD trajectory and inform future studies about potential targets and therapeutic strategies for addiction.
Who can apply
Eligible applicants
How to apply
Application links
Required documents
- SF-424 (R&R) Application Form
- Project Narrative (specific page limits apply)
- Research Strategy
- Biographical Sketches
- Budget and Budget Justification
- Resources and Environment
- Animal Protocol or IACUC Documentation
- NIH Inclusion Enrollment Report
Program contact
- 👤 National Institutes of Health
- 📧 grantsinfo@nih.gov
- 📞 301-402-2541
Funding track record
Recent awards under CFDA 93.279 from the last 3 years — real organizations that won funding through this same program.
Top 10 Largest Recent Awards
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$976,983,003
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$204,359,786
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$128,377,094
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$126,585,435
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$99,478,296
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$79,333,238
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$78,245,057
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$74,806,844
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$71,588,047
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$61,572,673
Top States by Funding
- NC 2 awards $1,006.2M
- NY 4 awards $261.1M
- WA 1 awards $204.4M
- CT 2 awards $155.8M
- CA 4 awards $141.9M
Source: USAspending.gov — federal spending transparency. Data covers last 3 years.
Funding history
Annual funding for this program — Federal obligations (CFDA 93.279). How funding has trended year over year.
| 2024 | $1,245,503,136 | |
| 2025 | $1,343,517,098 | |
| 2026 est. | $20,194,375 |
FAQ
Who can apply for this grant?
Universities, research institutes, hospitals, and other NIH-recognized organizations can apply. At least one applicant organization must be a U.S. institution.
What types of research are funded?
Animal genomics studies examining genetic factors in substance use disorder and addiction. Clinical trials are not permitted for this funding mechanism.
What is the typical funding range?
U01 grants typically support larger research projects. Check the NIH grant guide for specific budget limits and project duration policies.
How competitive is this funding?
NIH animal genetics funding is moderately to highly competitive. Strong preliminary data and clear methodology are essential.
When is the deadline?
The deadline is February 11, 2027. Applications must be submitted by 11:59 PM EST on the deadline date.
💡 Tips for applicants
- Highlight preliminary data showing the biological relevance of your animal model to human addiction pathways.
- Clearly describe your genomic methodology and explain why your animal system is essential for this research.
- Address how your findings will advance understanding of substance use disorder mechanisms.
- Engage an experienced grant administrator early to ensure compliance with NIH regulations.
- Request feedback from NIH program officers before submission to strengthen your application.
⚠️ Common mistakes
Proposing research too similar to existing NIH-funded studies without clear innovation. Failing to justify why animal models are necessary instead of cell-based or computational approaches. Underestimating budget detail—NIH reviewers expect specific, justified costs for all project components.
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