Mitigating Proliferation Risks Posed by Artificial Intelligence Enabled Molecular Models and Leveraging Nonproliferation Opportunities
🏛 Bureau of Arms Control and Nonproliferation (DOS-ACN)
✓ Free, no account · Source: Grants.gov · Last verified Jun 28, 2026
Can you apply?
This grant is for U.S. nonprofits, educational institutions, and for-profit organizations working on artificial intelligence nonproliferation. Applicants must address risks from AI-enabled chemical and biological models. U.S. federal government entities and foreign nonprofits cannot apply.
Proposals may target all key objectives or a specific subset. Organizations may partner with collaborators, including other applicants. No cost-sharing is required.
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Program description
The Department of State’s Office of the Nonproliferation and Disarmament Fund (ACN/NDF) is pleased to announce an open competition for assistance awards through this Notice of Funding Opportunity (NOFO). ACN/NDF invites domestic non-profit/non-governmental organizations, educational institutions, and for-profit organizations to submit proposals for projects that will advance the mission of NDF’s efforts to identify, evaluate, and develop safeguards to counter the misuse risks enabled by the proliferation of chemical and biological Artificial Intelligence (AI) models (CBAIMs). Proposals may not exceed the total availability of funds under this NOFO. ACN/NDF welcomes proposals that fully address all or a clearly articulated, targeted subset of the key objectives of this NDF line of effort (Section II). Please indicate whether the proposal involves collaboration with a partner organization that is separately responding to this solicitation.
Who can apply
Eligible applicants
How to apply
Application links
Key dates & requirements
Required documents
- SF-424 (Application for Federal Assistance)
- Project Narrative
- Budget and Budget Justification
- Organizational Capacity Statement
- CVs or resumes of key personnel
Program contact
- 👤 Bureau of Arms Control and Nonproliferation
- 📞 771-204-0446
Funding track record
Recent awards under CFDA 19.224 from the last 3 years — real organizations that won funding through this same program.
Top 10 Largest Recent Awards
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$7,058,065
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$4,042,633
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$2,499,355
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$2,354,510
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$2,200,000
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$2,190,185
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$2,000,000
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$1,941,970
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$1,600,000
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$1,397,529
Source: USAspending.gov — federal spending transparency. Data covers last 3 years.
Funding history
Annual funding for this program — Federal obligations (CFDA 19.224). How funding has trended year over year.
| 2024 | $1,000,000 | |
| 2026 est. | $127,672 |
FAQ
Who can apply for this grant?
U.S. nonprofits, educational institutions, and for-profit organizations. U.S. federal agencies and foreign nonprofits are ineligible.
What is the deadline?
The deadline is July 21, 2026. This is a fixed deadline with no rolling acceptance.
What activities does this grant support?
Projects that develop safeguards against misuse of chemical and biological AI models. This includes identifying, evaluating, and countering proliferation risks.
How much funding is available?
Up to $4,000,000 in total. The exact award amount depends on proposal merit and scope.
Can organizations collaborate on a single proposal?
Yes, partnerships are allowed. Indicate if your partner organization is separately submitting to this competition.
💡 Tips for applicants
- Directly address the key objectives listed in Section II of the NOFO. Vague alignment will weaken your proposal.
- If proposing a subset of objectives, clearly articulate which ones and why they're the priority.
- Describe your specific safeguards or solutions. Generic nonproliferation language won't be competitive.
- If collaborating, clarify roles and explain why partnership strengthens your approach.
- Budget strategically. You have $4,000,000 total pool; larger requests need stronger justification.
⚠️ Common mistakes
Proposals that don't clearly map to Section II key objectives get rejected. Vague descriptions of AI safeguards lack credibility. Failing to clarify collaboration structures confuses reviewers about accountability.
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