Limited Competition: The NHGRI Analysis, Visualization, and Informatics Lab-space (AnVIL) (U54 Clinical Trial Not Allowed)
🏛 National Institutes of Health (HHS-NIH11)
✓ Free, no account · Source: Grants.gov · Last verified Jul 15, 2026
Can you apply?
This grant is for researchers and organizations seeking to advance a secure, cloud-based genomic data platform (AnVIL). Eligible applicants must have capacity to develop and maintain research infrastructure supporting large-scale genomic analysis. The program prioritizes platform development, data interoperability, security infrastructure, and workforce training in genomics. This is a limited competition renewal, meaning only pre-identified organizations may be invited to apply.
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Key dates
- Jun 2, 2026 Applications open
- May 25, 2027 Application deadline in 312 days
- Jun 1, 2028 Award announced
- Jun 1, 2028 Project start
Program description
The National Human Genome Research Institute (NHGRI) intends to issue a Notice of Funding Opportunity (NOFO) to support a limited competition renewal of the Analysis, Visualization, and Informatics Lab-space (AnVIL) program. AnVIL is a secure, cloud-based platform that enables researchers to access, share, and analyze large-scale genomic datasets without relying on local infrastructure. Currently, AnVIL hosts more than 5 petabytes of data from nearly 300,000 research participants, providing a robust environment for reproducible, cloud-native genomic research.
The renewed program will continue to advance AnVIL as a community resource grounded in FAIR (Findable, Accessible, Interoperable, and Reusable) principles. Key priorities include enhancing scalability; strengthening interoperability across a federated NIH data ecosystem; and maintaining rigorous security aligned with the Research Authentication Service (RAS) and NIH controlled-access data repositories and access management systems (CADR) requirements (see NOT‑OD‑25‑159). The renewal will also support integration of emerging data types and computational tools, including infrastructure for developing and running AI-based methods and complex analysis workflows.
In addition to platform development, the program will expand training and outreach to help researchers effectively use AnVIL’s multimodal datasets and reproducible analysis capabilities. By connecting secure data access, analytical tools, and workforce development, the renewed AnVIL program aims to accelerate discovery across the research lifecycle and strengthen the genomics community’s capacity for clinical and translational science.
This Notice is being provided to allow potential applicants sufficient time to develop responsive applications. The NOFO is expected to be published in 2027 with an anticipated application due date in 2027. This NOFO will utilize the U54 activity code.
This is a Forecast for a limited competition that will invite application(s) from eligible organization(s) to apply. Please see Eligibility Section for additional information. In accordance with NIH standard peer-review processes, the application(s) will be peer-reviewed, and only meritorious application(s) will be considered for funding.
Who can apply
Eligible applicants
How to apply
Application links
Key dates & requirements
Required documents
- SF-424 (Research and Related Project Description form)
- Project Narrative
- Budget and Budget Justification
- Biosketches of key personnel
- Statement of institutional support and resources
- Data management and security plan
Program contact
- 👤 Office of the Director / Office of Genomic Data Science
- 📧 anvil@mail.nih.gov
- 📞 Please contact via e-mail.
Funding track record
Recent awards under CFDA 93.172 from the last 3 years — real organizations that won funding through this same program.
Top 10 Largest Recent Awards
-
$39,531,110
-
$34,574,245
-
$32,186,204
-
$30,195,606
-
$26,495,937
-
$26,020,371
-
$24,964,130
-
$24,413,854
-
$23,757,911
-
$22,977,417
Top States by Funding
- CA 19 awards $317.2M
- MA 16 awards $302.5M
- WA 9 awards $140.1M
- NY 6 awards $93.6M
- NC 5 awards $93.0M
Source: USAspending.gov — federal spending transparency. Data covers last 3 years.
Funding history
Annual funding for this program — Federal obligations (CFDA 93.172). How funding has trended year over year.
| 2024 | $452,727,668 | |
| 2025 | $423,878,429 | |
| 2026 est. | $9,989,158 |
FAQ
Who can apply for this grant?
This is a limited competition. Only eligible organizations pre-identified by NHGRI will be invited to apply. Check the full NOFO when published in 2027 for specific details.
When is the deadline?
The application deadline is May 25, 2027. The full NOFO will be published in 2027 with the formal due date.
What activities are supported?
AnVIL platform development, enhanced scalability, data interoperability, security infrastructure, AI/computational tool integration, and training and outreach to researchers.
How competitive is this award?
This is a limited competition renewal using the U54 cooperative agreement mechanism. Only meritorious applications will be funded through standard NIH peer review.
What is the funding range?
The total program pool is $8 million. Individual award amounts are not specified in the forecast.
💡 Tips for applicants
- Begin planning now. The deadline is 2027, but application development for infrastructure grants is lengthy. Draft your institutional capacity and technical approach early.
- Emphasize FAIR data principles and NIH data ecosystem interoperability. Security compliance with RAS and CADR requirements is a non-negotiable priority.
- Highlight your organization's track record managing large-scale genomic datasets and cloud-based infrastructure. Existing partnerships strengthen competitiveness.
- Plan for workforce development components. Training and outreach activities are explicitly prioritized alongside technical platform work.
- Build a multidisciplinary team. Success requires expertise in genomics, bioinformatics, cloud infrastructure, security, and scientific communication.
⚠️ Common mistakes
Underestimating security and compliance demands. CADR and RAS alignment is mandatory, not optional. Failing to integrate workforce training. This program funds both infrastructure and community capacity. Proposing isolated technical solutions without addressing interoperability with the broader NIH data ecosystem.
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