Limited Competition: Specific Pathogen Free Macaque Colonies to Support HIV/AIDS Research (U42 Clinical Trial Not Allowed)
🏛 National Institutes of Health (HHS-NIH11)
✓ Free, no account · Source: Grants.gov · Last verified Jul 16, 2026
Can you apply?
This grant is for research institutions and organizations seeking to establish or maintain specific pathogen free (SPF) macaque colonies for HIV/AIDS research.
Eligible applicants include academic medical centers, universities, and NIH-supported research facilities. The grant supports non-clinical trial research using primate models to study HIV/AIDS pathogenesis and treatment approaches.
The research scope is limited to basic science and translational studies. Clinical trials are explicitly not allowed under this mechanism. Priority is given to projects that expand availability of SPF macaque colonies for the research community.
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Program description
The purpose of this Notice of Funding Opportunity (NOFO) is to provide continuing support for specific pathogen-free (SPF) macaque colonies previously funded under the auspices of PAR-21-089 and PAR-18-669 that support Human Immunodeficiency Virus (HIV)/Acquired Immunodeficiency Syndrome (AIDS) research. Breeding colonies are essential to sustain appropriate SPF macaques for research related to HIV/AIDS. Pedigree SPF macaques are free of certain viruses, which may confound the results of HIV/AIDS-related investigations or present a risk to the personnel who care for the animals. The SPF macaques are genetically characterized for major histocompatibility complex (MHC) class I types, because MHC class I genotypes have large effects on macaque immune responses to Simian Immunodeficiency Virus (SIV) that can induce AIDS in nonhuman primates (NHPs) and on human immune responses to HIV.
Who can apply
Eligible applicants
How to apply
Application links
Required documents
- SF-424 (R&R) Federal Application Form
- Project Narrative (research plan and colony management strategy)
- Budget and Budget Justification
- Institutional biosafety and IACUC approval letters
- Veterinary health records and pathogen screening documentation
- Letters of support from potential colony users
- Facilities and Equipment description
Program contact
- 👤 National Institutes of Health
- 📧 grantsinfo@nih.gov
- 📞 301-402-2541
Funding track record
Recent awards under CFDA 93.351 from the last 3 years — real organizations that won funding through this same program.
Top 10 Largest Recent Awards
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$203,025,735
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$201,841,608
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$191,271,017
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$156,271,917
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$150,172,413
-
$133,830,113
-
$129,717,894
-
$37,946,246
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$37,475,785
-
$33,594,411
Top States by Funding
- OR 7 awards $290.0M
- CA 8 awards $266.7M
- WA 2 awards $232.0M
- TX 9 awards $228.2M
- LA 6 awards $189.8M
Source: USAspending.gov — federal spending transparency. Data covers last 3 years.
Funding history
Annual funding for this program — Federal obligations (CFDA 93.351). How funding has trended year over year.
| 2024 | $279,889,905 | |
| 2025 | $284,089,258 | |
| 2026 est. | $283,084,958 |
FAQ
Who can apply for this grant?
Academic institutions, universities, research centers, and NIH-supported facilities with expertise in primate care and HIV/AIDS research are eligible. Organizations must have institutional biosafety and IACUC approval capacity.
Are clinical trials allowed?
No. This limited competition explicitly excludes clinical trial applications. Research must focus on basic science and translational studies using primate models.
What types of research are supported?
The grant supports establishment and maintenance of specific pathogen free macaque colonies. Research examining HIV/AIDS pathogenesis, vaccine development, and therapeutic strategies are priority areas.
What is the application deadline?
The deadline is September 25, 2026. Applications typically open several months before the deadline date.
How competitive is this funding?
This is a limited competition, meaning a restricted pool of eligible applicants. Success depends on colony quality, research design, and community benefit of making colonies available.
💡 Tips for applicants
- Demonstrate your facility's current SPF macaque colony capacity and health status with recent veterinary records and pathogen screening data.
- Explain how your colony will support the broader research community, not just your internal projects.
- Include letters of support from researchers who would use your facility to strengthen community impact.
- Provide detailed animal care protocols, housing specifications, and compliance documentation for IACUC and institutional standards.
- Budget realistically for ongoing colony maintenance, veterinary care, and pathogen monitoring over the grant period.
⚠️ Common mistakes
Proposing clinical trial research, which is explicitly prohibited. Lack of clear evidence of community benefit or access to the macaque colony. Underestimating long-term costs for colony maintenance and veterinary care.
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