High Priority HIV and Substance Use Research (R01 Clinical Trial Optional)
Can you apply?
This grant is for biomedical researchers investigating HIV and substance use disorders. Eligible applicants include researchers at academic institutions, hospitals, research organizations, and nonprofit entities with established research capabilities. Priority is given to research addressing co-morbidities between HIV and substance use. Geographic scope is U.S.-based institutions receiving federal funding. Eligible activities include basic research, clinical trials (optional), and implementation science projects advancing prevention, treatment, or management strategies.
This grant is for biomedical researchers investigating HIV and substance use disorders. Eligible applicants include researchers at academic institutions, hospitals, research organizations, and nonprofit entities with established research capabilities. Priority is given to research addressing co-morbidities between HIV and substance use. Geographic scope is U.S.-based institutions receiving federal funding. Eligible activities include basic research, clinical trials (optional), and implementation science projects advancing prevention, treatment, or management strategies.
Program description
The purpose of this Funding Opportunity Announcement (FOA) is to support high priority research at the intersection of HIV and substance use. This FOA invites innovative research projects with the potential to open new areas of HIV/AIDS research and/or lead to new avenues for prevention, treatment and cure of HIV among people who use drugs (PWUD). Applications submitted under this FOA are required to have a detailed research plan, preliminary data, and a clear description of the nexus with substance use. This FOA is open to both individual researchers and research teams and includes all areas of research from basic science to clinical and implementation research. All studies must focus on NIH HIV/AIDS Research Priorities: NOT-OD-20-018: UPDATE: NIH HIV/AIDS Research Priorities and Guidelines for Determining HIV/AIDS Funding.
Who can apply
Eligible applicants
- 501(c)(3) Public Charity
- City / Municipal Government
- County Government
- Hospital
- Nonprofits
- Private University
- Public Authority
- Public K-12 School
- Public University
- Small Business (SBA-defined)
- Special District
- State Government
- Tribal Nation
- Tribal Organization
Demographic focus
Details
This grant is for biomedical researchers investigating HIV and substance use disorders. Eligible applicants include researchers at academic institutions, hospitals, research organizations, and nonprofit entities with established research capabilities. Priority is given to research addressing co-morbidities between HIV and substance use. Geographic scope is U.S.-based institutions receiving federal funding. Eligible activities include basic research, clinical trials (optional), and implementation science projects advancing prevention, treatment, or management strategies.
How to apply
Application links
Required documents
- SF-424 (R&R) Cover Sheet
- Project Narrative (Research Plan)
- Budget Justification
- Biographical Sketches (Key Personnel)
- Facilities & Administrative Costs Narrative
- Letters of Support/Commitment
- IRB Approval (if human subjects research)
- Data Management & Sharing Plan
Program contact
- 👤 National Institutes of Health
- 📧 grantsinfo@nih.gov
- 📞 301-402-2541
Funding track record
Recent awards under CFDA 93.279 from the last 3 years — real organizations that won funding through this same program.
Top 10 Largest Recent Awards
-
$128,078,833
-
$126,585,435
-
$79,333,238
-
$78,351,755
-
$74,806,844
-
$71,588,047
-
$61,578,651
-
$50,344,757
-
$41,820,011
-
$39,479,041
Top States by Funding
- NY 4 awards $260.8M
- CT 2 awards $155.8M
- CA 3 awards $90.2M
- KY 1 awards $79.3M
- MA 1 awards $78.4M
Source: USAspending.gov — federal spending transparency. Data covers last 3 years.
Funding history
Annual funding for this program — Federal obligations (CFDA 93.279). How funding has trended year over year.
| 2024 | $1,245,503,136 | |
| 2025 | $1,343,517,098 | |
| 2026 est. | $20,194,375 |
FAQ
Who can apply for this grant?
Research institutions, universities, hospitals, and nonprofits with research infrastructure. Eligible principal investigators must have appropriate credentials and institutional support.
What is the application deadline?
The deadline is March 6, 2027. Applications typically open 3-4 months before the deadline.
Can I propose a clinical trial?
Clinical trials are optional but encouraged if scientifically justified. Budget and timeline must reflect trial-specific requirements.
How competitive is this funding?
NIH R01 awards are highly competitive. Success rates typically range 15-20% across all NIH grants.
What is the typical funding range?
R01 awards usually provide $250,000–$500,000 annually for 3-5 years, depending on project scope.
💡 Tips for applicants
- Build strong preliminary data demonstrating feasibility before applying. NIH expects substantial evidence of innovation.
- Align your research question directly with stated NIH priorities for HIV and substance use research.
- Develop a realistic timeline with clear milestones. Reviewers scrutinize overambitious or vague schedules.
- Assemble an experienced, multidisciplinary team with complementary expertise in your research area.
- Budget carefully and justify all costs. Unexplained or inflated budgets trigger reviewer concerns.
⚠️ Common mistakes
Weak preliminary data undermines credibility; reviewers need evidence your approach works. Misalignment with NIH strategic priorities wastes reviewer time and reduces scores. Overly broad aims that cannot be accomplished in the proposed timeline invite skepticism.
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